Tetanus Stimulation for Treatment of Chronic Tinnitus

Discussion in 'Research News' started by Frédéric, Sep 1, 2019.

    1. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Marseille, France
      Tinnitus Since:
      Cause of Tinnitus:
      acoustic trauma
      Study on treatment of chronic tinnitus by tetanus stimulation and evaluation methods of tinnitus.

      DOI: 10.13201/j.issn.1001-1781.2019.09.015 View attachment 31712


      The purpose of this study was to explore the efficacy of tetanus stimulation in tinnitus treatment and the correlation between the mainstream questionnaires of tinnitus and tinnitus-matching in order to find a more convenient and accurate method for tinnitus evaluation.

      Ten patients with chronic tinnitus and normal or mild hearing impairment were enrolled in this study, totaling 13 ears. Their age ranged from 23 to 53 years old. The stimulus sound(white noise, frequency modulation 14.1 Hz, repetitive amplitude modulation, duty cycle 0.5) was selected and the sound intensity was 50 dB SL.

      Experimental procedure:
      (4 minutes sound stimulation+4 minutes rest) ×4 times, totaling 32 minutes. The patients were treated three times a week for 5 weeks. The loudness of tinnitus was matched before and after each treatment, and tinnitus handicap inventory(THI), tinnitus handicap questionnaire(THQ) and visual analog scales(VAS) were also used for assessment before the first treatment each week. The loudness matching and the above scales were performed once more at follow-up for one week after end-of-treatment.

      ①Single treatment: the matched loudness value decreased by 1.000(0.000, 3.000) dB(Z=7.553, P<0.01) after each single treatment.
      ②After five weeks' treatment: the matched loudness value decreased(9.692±8.038) dB(t=4.348, P<0.01); VAS value decreased by 2.000(1.000, 3.000)(Z=2.890, P<0.01); total score of THQ decreased(7.389%±8.847%)(t=2.641, P<0.05).
      ③Correlation analysis: there was positive correlation between total scores of THI and THQ(r=0.747, P<0.01); the matched loudness values have positive correlation with VAS value(r=0.593, P<0.01), THI-F(r=0.346, P<0.01) and THQ-factor 3 score(r=0.294, P<0.05); there was positive correlation between the VAS value and THI-F(r=0.326, P<0.05), the total score of THI(r=0.466, P<0.01), THQ-factor 3 score(r=0.291, P<0.05), the total score of THQ(r=0.497, P<0.01).

      The loudness of tinnitus declined with significant fluctuation during tetanus sound therapy. THQ scale is recommended as a sensitive indicator for evaluating the efficacy of tinnitus treatment; VAS is recommended for rapid assessment of tinnitus. Tetanus stimulation is expected to become an important direction in tinnitus sound therapy.

      Source: https://europepmc.org/abstract/med/31446705
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    2. Ecip

      Ecip Member

      Edmonton, AB/Switzerland
      Tinnitus Since:
      Cause of Tinnitus:
      Still unknown... possibly noise exposure?
      Tetanus stimulation.... they're stimulating an infectious disease?
      • Good Question Good Question x 2
    3. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      I suspect the word tetanus has a different meaning in this context. More to do with affecting a change with a repeated stimulus. I've heard of amplitude modulation of sounds influencing tinnitus before. Could be something in it. And it's something a DIY electronics nerd could do themselves.
    4. InfiniteLoop

      InfiniteLoop Member Benefactor

      Redwood City, California
      Tinnitus Since:
      Cause of Tinnitus:
      High frequency hearing loss in left ear from head trauma (?)
      SoundCure was the leading company in amplitude modulation sound therapy and it went under because of underwhelming results. There is a never ending chain of sound therapies leading nowhere. Beyond masking, and residual inhibition, there is very little to prove that sound will do anything useful and much less to undo actual neural damage.

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