Acamprosate (Campral)

Discussion in 'Treatments' started by tweak, May 16, 2012.

    1. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      It's an NMDA antagonist +"The drug also protected infant hamsters from brain damage induced by injections of the toxin ibotenic acid(which exacerbates excitotoxicity, the harmful over-activation of glutamatereceptors)" What happens when tinnitus first starts? Over-activation of glutamatereceptors. There could be a time-limit which is why I suggested it.
       
      • Informative Informative x 1
    2. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      magnesium is also proven to prevent certain kinds of neural damage. glutamate storms are glutamate storms. that does not mean that magnesium has much in common with AM-101 (ketamine), or that ketamine has much in common with campral.
       
    3. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      All I'm saying is, there may be a time limit. I would like to know if this could help with people under 12 months or 6 months or 3 months. Anyway, I'm using it and it does seem to lower the tone/pitch. I do monitor mine on a daily basis. Anyway, it does help some people, so I wouldn't call this a drug which couldn't help. I'll see in two months after I'm off of all these drugs to see if it all worked...I just can't handle 10/10 tinnitus...You would not believe how much I appreciate silence now...Jesus, I never thought I would appreciate it this much.
       
    4. Christian78
      Alone

      Christian78 Member

      Location:
      Gothenburg
      Tinnitus Since:
      (Sep 2013)
      Cause of Tinnitus:
      progressive tinnitus, time of expiring in next 3-6 months
      Daniel is tough bug. You can enter Swedish medical storage and eat it all and go out and burp and is that all :D
       
    5. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Cheeky haha!
       
      • Hug Hug x 1
    6. lost horizons

      lost horizons Member

      Tinnitus Since:
      June 2014
      has anyone on the forum tried acamprosate recently? If so, was it effective was the dosage 333 MG three times a day. I read anew Indian study that showed it to be effective in reducing T and other than diarrhea and gas, apparently there are no major side effects, unlike trobalt.
       
      • Good Question Good Question x 1
    7. Carm

      Carm Member

      Tinnitus Since:
      04/01/2011
      Indian studies can be scams. They thought Caroverine was effective. It is not.

      Acamprosate has been proven in clinical tests not to be effective for tinnitus.
       
    8. lost horizons

      lost horizons Member

      Tinnitus Since:
      June 2014
      Has anyone tried acamposate ?
       
    9. Calories
      Surrender

      Calories Member

      Location:
      Bangalore, India
      Tinnitus Since:
      March 2015
      Cause of Tinnitus:
      B12 Difficiency, Possibly salycilic poising from fenugreek and ginger
    10. Manuel Tissm
      Angry

      Manuel Tissm Member

      Location:
      Portugal
      Tinnitus Since:
      07/2014
      Cause of Tinnitus:
      Acoustic trauma
      Do you tried acamposate ?
       
    11. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      I've been on it for like 2 months.
       
    12. uae96
      Thinking

      uae96 Member

      Location:
      Dubai
      Tinnitus Since:
      6/14/2015
      Cause of Tinnitus:
      Noise induced
      Is that drug widely available or is there any restrictions (nasty side effects etc...)??
       
    13. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      There's not really any serious side-effects.
       
    14. uae96
      Thinking

      uae96 Member

      Location:
      Dubai
      Tinnitus Since:
      6/14/2015
      Cause of Tinnitus:
      Noise induced
      U think it's worth a try ?
       
    15. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Well, maybe. I can't tell you if it works, as I was on 3 different types of drugs.
       
      • Agree Agree x 1
    16. shantelle

      shantelle Member

      Tinnitus Since:
      04/2015
      Cause of Tinnitus:
      noise induced
      Can we start a poll too see how many people tried and if it worked. Anyone have any positive results on taking campral?
       
    17. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      It never worked for me. Pretty much useless. I would use it for benzo withdrawal myself.
       
    18. Kyxwz
      No Mood

      Kyxwz Member

      Tinnitus Since:
      x
      Cause of Tinnitus:
      x
      Acamprosate (Campral®) is approved for the treatment of alcoholism in the U.S. and Europe. It presumably blocks excitatory glutamatergic N-methyl-d-aspartate (NMDA) receptors (5961) while enhancing γ-aminobutyric acid (GABA)-mediated nerve inhibition (6264). However, some studies indicate that acamprosate enhances NMDA function, while others indicate that the compound enhances NMDA-induced excitability at low concentrations and suppresses it at high concentrations (6265). Other reports suggest that acamprosate has no effect on GABA-mediated currents (66), and some reports suggest that acamprosate inhibits the binding of taurine to taurine receptors (67).

      One paper has been published on the use of acamprosate to treat tinnitus patients, most of whom had mild to profound noise-induced hearing loss (68, 69). The rationale for treatment assumes that tinnitus arises from excess glutamatergic activity through NMDA receptors and/or hyperactivity resulting from the loss of GABA-mediated inhibition (7075). In this double-blind study, patients received placebo or acamprosate (333 mg t.i.d.) and rated the loudness and annoyance of their tinnitus before and at monthly intervals of treatment. Acamprosate had no beneficial effects after 30 days of treatment, a modest benefit at 60 days and a significant effect at 90 days. Approximately 87% of the subjects in the acamprosate group showed some improvement, including three subjects in whom tinnitus disappeared, compared to 44% in the placebo group. A larger clinical trial is currently under way to further assess the encouraging results from this preliminary study (http://clinicaltrials.gov/ct2/show/NCT00596531).

      Is there anyone that have try CAMPRAL 666mg x3 daily for three months?!
       
      • Good Question Good Question x 1
    19. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      Tried it for 14 days. Didnt do anything for my T nor my benzo withdrawl. Maybe I should have stayed on it longer. Didnt know about the 90 days to have any reportable affect
       
    20. Beste
      Disappointed

      Beste Member

      Tinnitus Since:
      02/16/2016
      Cause of Tinnitus:
      Benzo/Clonazepam, Stress
      Is this drug only effective in benzo w/d or is it also effective for benzo induced T? God I really do not know what medicine to begin with.

      And do you guys take these drugs under a doctor's control or just like go in a pharmacy and take a box of it? I do not really want to see a doc again in my life since they ruined my whole life.
       
      • Hug Hug x 1
    21. Kyxwz
      No Mood

      Kyxwz Member

      Tinnitus Since:
      x
      Cause of Tinnitus:
      x
      Think that: i have tinnitus for acoustic trauma and Clonazepam 2mg it's (for now) the only thing that work to quiet it... :( and clonazepam cause you Tinnitus.

      You could try campral for three months under 666mg three time daily and see who happen. It's an easy medicine without collateral effect; you can try with your doctor. I have one box, and i have try it just for two weeks; short period and don't seem that work but i must try for a long period. Just before i want use perampanel and trobalt to see if something of good happen (also after suspension).
       
      • Like Like x 1
    22. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      Its primary used to make alcoholics not want to drink. To deminish the urge. Its a GABA agonist and Glutumate antagonist wich sounds good, but thats all I know.
       
    23. Kyxwz
      No Mood

      Kyxwz Member

      Tinnitus Since:
      x
      Cause of Tinnitus:
      x
      With an high probably that some brazilian reasearch are scam. (Acamprosate it's a brazilian drug...)
       
    24. Beste
      Disappointed

      Beste Member

      Tinnitus Since:
      02/16/2016
      Cause of Tinnitus:
      Benzo/Clonazepam, Stress
      I just read some study that saying this drug can be ototoxic. Damn.
       
    25. JasonP
      No Mood

      JasonP Member

      Tinnitus Since:
      6/2006
    26. Foncky
      Tired

      Foncky Member Benefactor

      Location:
      Europe
      Tinnitus Since:
      March 2004
      Cause of Tinnitus:
      Music. Balloon. Genes.
      It might mean "three times a day" in Latin (doctors and Latin...).
       
    27. Tigo

      Tigo Member

      Tinnitus Since:
      2 years
      Cause of Tinnitus:
      genetic hearing loss
      Anyone tried Campral this last year? Any success?
       
    28. gotyoubynuts

      gotyoubynuts Member

      Tinnitus Since:
      10/1990
      Cause of Tinnitus:
      Concert
      It's been proven not to work for tinnitus so no use trying...
       
    29. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Indeed doesn't work sadly.
       
    30. dan26
      Frustrated

      dan26 Member

      Location:
      NJ
      Tinnitus Since:
      1981
      Cause of Tinnitus:
      complete loss of hearing. motorcycle accident
      Doctor prescribed acamprosate and i took it for about a month or so. Study says it must be taken at least 3 months. I will have to try for 3 months then see whats up with the T. Praying for a cure....
       

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