Acamprosate (Campral)

Discussion in 'Treatments' started by tweak, May 16, 2012.

tinnitus forum
    1. tweak

      tweak Member

      Tinnitus Since:
      03/12
      • Like Like x 1
    2. Molan
      No Mood

      Molan Member

      Tinnitus Since:
      2005
      No I haven't tried this but kudos to you this is an excellent find!!!
       
    3. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      Treatment of tinnitus with acamprosate.

      Azevedo AA, Figueiredo RR.
      Source

      OTOSUL, Otorrinolaringologia Sul-Fluminense, Volta Redonda, Vila Santa Cecília, Rio de Janeiro, Brazil. otosul@otosul.com.br
      Abstract

      Acamprosate, a drug used to treat alcohol dependence, was first reported as a potential treatment for tinnitus in 2005. The drug may improve tinnitus by a dual mechanism of action, acting both as a glutamate antagonist and as a GABA agonist. It is suggested that its action may be both on the ear and the nervous system.
      PMID:
      17956791
      [PubMed - indexed for MEDLINE]
      http://www.ncbi.nlm.nih.gov/pubmed/17956791
       
    4. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      Gosh... so sorry tweak. Didn't see you thread. Oppsie
       
      • Informative Informative x 1
    5. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      OHSU, Oregon Health and Sciences Univ did an extensive study on this a couple years ago funded by ATA and came to conclusion it didn't work any better than placebo I believe.
       
    6. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      oh geez... thanks erik! That's why we don't see more of this product.
       
    7. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
    8. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Cool Joe, I'm pulling for you!
       
    9. tweak

      tweak Member

      Tinnitus Since:
      03/12
    10. mock turtle

      mock turtle Member

      Location:
      puget sound
      Tinnitus Since:
      07/26/1992...habituated after 2 years; 11/04/11 new outbreak
      i keep reading about how darn effective that stuff is, thats called , placebo

      im wondering

      anyone know where i can order a bottle of placebo ?

      ;)
       
    11. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      lol Mock, I think if I participate in any studies I want the placebo...
       
    12. Karl

      Karl Member Benefactor

      Location:
      Chicago
      Tinnitus Since:
      10/2011
      From joe's link:

      "RESULTS:

      "At the end of the study, the drug had shown a statistically significant improvement in reducing the tinnitus score in 92.5% of the patients and placebo with an improvement in 12.5% of the patients. The drug was well tolerated without any serious drug reactions."

      Hey....this is good....right?

      I will need to read this more thoroughly tomorrow! Sounds like major news.
       
    13. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Karl, it was too good to be true. OHSU studied this with over 500 people, I believe which was the largest study conducted on acamprosate and the conclusion was that there were no significant differences between the effects of the placebo and the study drug, Acamprosate. it concluded earlier this year.
       
      • Like Like x 1
      • Agree Agree x 1
    14. Azevedo Andréia

      Azevedo Andréia Member

      Tinnitus Since:
      2000
      THE OHSU USED THE DOUBLE DOSE THAN WE DID AND THEY USED A DIFFERENT DESIGN TOO,VERY DIFFERENT FROM ANY ONE. THERE ARE TOO MANY BLIND POINTS THERE..THEY HAD TOO MANY SIDE EFFECTS AND TOO MANY PEOPLE GAVE UP BEFORE STARTING TAKING THE DRUG,PROVING THAT PATIENTS WERE NOT MOTIVATED FROM THE TEAM.THE INDIAN STUDY USED THE SAME DOSE WE DID AND GOT THE SAME RESULTS.ANOTHER THING YOU NEED TO HAVE IN MIND IS THAT TINNITUS CAN BE A SYMPTOM FROM MANY DISEASES AND CAN HAVE A IMBALANCE FROM MANY NEUROTRANSMITTERS IN THE BRAIN ,EXCITATORY OR INHIBITHORY ,SO IT IS IMPOSSIBLE TO HAVE ONE MAGIC PILLS.IN MY OPINION PLACEBO BLIND THE SCIENTIST AND THEY FORGET TO SEE WHAT HAPPEN TO THE PATIENTS THAT GOT BETTER ,WHAT ARE THEIRS SUB GROUPS?I WOULD LIKE THAT MORE DOCTORS GOT AN INTERESTING IN TINNITUS FIELD.IT HAS BEEN TOO DIFICULT TO INTRODUCE MANY DRUGS IN THIS FIELD,BECAUSE THERE ARE ANOTHERS INTERESTING IN THIS FIELD.IN SOUTH AMERICA AND IN THE REST OF THE WORLD,I THINK WE HAVE MORE DOCTOR INVOLVED THEN IN AMERICA.THAT IS WHY DRUG TO TINNITUS IS TAKING SO LONG TO BE THE STRONGER POINT .THAT IS JUST MY OPINION.NO OFENSE.
       
    15. click
      Busy

      click Member Benefactor

      Location:
      West Cornwall, England, UK
      Tinnitus Since:
      06/04/2012
      Cause of Tinnitus:
      Not sure
      a 'guy'?? that drank every day....

      jenniferdraper.jpg
       
    16. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Acamprosate was developed to help alcoholics stop drinking by returning the brain changes back to "normal" due to alcoholism. Again, not proven to help with Tinnitus in controlled double blind studies.
       
    17. Don H

      Don H Member

      Location:
      Edmonton
      Tinnitus Since:
      09/2009
      I had my doc prescribe it to me in the same dosage as an earlier successful trial. The brand name in Campral from Forrest laboratories. Took it for a couple with no real change.
       
      • Helpful Helpful x 1
    18. David King
      No Mood

      David King Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      Dec 2011
      I have also tried Campral for a couple of months. No change in t for me either.
       
      • Helpful Helpful x 1
    19. Louise

      Louise Member Benefactor

      Location:
      Yorkshire, UK
      Tinnitus Since:
      29/06/2012
      I asked OHSU about the results of a trial they were doing for Acamprosate helping T. Here's the email I got.....

      Louise,
      Thanks for asking about the study. We have finished it and are writing it up for publication. The results have been presented in preliminary form at the International Tinnitus Society meeting last year in Brazil. We could find no difference in the effectiveness of Acamproate compared to placebo in an extended, very carefully done study.

      Billy Martin

      William Hal Martin, Ph.D.
      Professor of Otolayrngology/Head & Neck Surgery
      Director, OHSU Tinnitus Clinic
       
    20. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      Ok... who wants to try this? :)

      http://www.freshpatents.com/-dt20100715ptan20100179220.php

      Abstract: Acamprosate, a drug used in the treatment of alcoholism, is a safe and successful alternative for neurossensorial tinnitus' treatment. ..

      SUMMARY

      OF THE INVENTION
      In order to evaluate efficacy and safety of acamprosate in the treatment of tinnitus and preferable sensorineural tinnitus, a randomized clinical trial has been performed wherein patients with sensorineural tinnitus were divided in two groups: 25 received acamprosate and 25 placebo, for a period of 3 months, in a prospective double-blind study, being analyzed for its efficacy and safety, among a subjective rate given for the patient from 1 to 10. Surprisingly a high index of success in the relief of tinnitus, about 86.9% has been found. In 47.8% of the cases more than 50% of relief has been found. The incidence of side effects was low, 12%, all of them mild. Thus, acamprosate, a drug used in the treatment of alcoholism, is a safe and successful alternative for neurossensorial tinnitus\' treatment.

      The chemical name acamprosate is calcium acetyl-homotaurinate or acetylaminopropanosulfonate whose chemical structure is analogous to some pharmacologically active amino acids, such as GABA, glutamate and taurine.

      Acamprosate increases the number of reuptake sites of GABA and modified GABA reuptake in rats, with global effects of increased GABA transmission, which inhibits the excitation of auditory pathways (Monografia do Acamprosato. MERCK).
      Acamprosate reduces the effect of excitatory amino acids (glutamate) in the central nervous system, especially its excitatory action over NMDA receptors, probably owing to an action at the level of calcium channel blockers (Monografia do Acamprosato. MERCK; Kratzer U, Schmidt W J. Caroverine inhibits the conditioned place aversion induced by naloxone-precipitated morphine withdrawal in rats. Neuroscience October 2003; 349 (2): 91-4).
      Acamprosate has not been mentioned in any reference of the literature for use in the treatment of tinnitus. Its dual action mechanism, which reduces the glutamatergic transmission (excitatory) and increases the GABA activity (inhibitory), together with its excellent tolerability, makes it an excellent and promising drug for tinnitus.

      Read more at the above link....
       
    21. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
    22. dan26
      Frustrated

      dan26 Member

      Tinnitus Since:
      1981
      Cause of Tinnitus:
      complete loss of hearing. motorcycle accident
      I read about this online and my oto-neurologist said study didn't involve a lot of people. only 40 in India.
       
    23. Lulubug69
      Artistic

      Lulubug69 Member

      Tinnitus Since:
      9/2013
      I've been researching a drug called Camprol (acampresate). I tried to find something here about it, but don't see anything. There has been a study or 2 regarding its success, I've read a couple of studies. Not very computer savvy so I will show where I found it. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271548/ curious if anyone has tried it, been offered it or has any additional info?

      *PS. Seems the study posted after all.
       
    24. Lulubug69
      Artistic

      Lulubug69 Member

      Tinnitus Since:
      9/2013
      What is sensationaural T?
       
    25. Hopeful
      Wishful

      Hopeful Member Benefactor

      Tinnitus Since:
      06/13
      If you mean 'sensorineural', then it refers to tinnitus caused by a sensorineural hearing loss, hearing loss due to damage to the inner ear (loss of inner hars cells, that transforms vibrations to neural activity (sound) in the brain)
       
    26. Lulubug69
      Artistic

      Lulubug69 Member

      Tinnitus Since:
      9/2013
      Thanks!
       
    27. divij

      divij Member

      Tinnitus Since:
      09/2013
      Hello everybody,
      I apologise in advance if this is a repost.
      There was a study done in India regarding T of sensorineural origin.
      Below is the link for the same..
      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271548/

      The name of the drug is acamprosate (brand name: Campral)
      The study was controlled and double blind with placebo. However(?), the effects were 2good2btrue!!!
      One good thing this drug has going for it is it is 1 of the very few drugs which are both NMDA antagonist and GABA agonist (wow!)
      Can our team of elite scientists decode the jargon and say if it is legit?
      Thank you in advance :)
      Divij
       
    28. Valentin

      Valentin Member

      Location:
      Thailand
      Tinnitus Since:
      17/08/2013
      as valuable as the clonazepam deanxit combo...
       
    29. Steve H
      Creative

      Steve H Director Staff Benefactor Team Trobalt Team Tech Team Awareness Team Research

      Location:
      York, UK
      Tinnitus Since:
      2003
      Cause of Tinnitus:
      Flu, Noise-induced, Jaw trauma
      Interesting,

      The study looks to be well designed, outcomes are good. The only concern is that there is no mention of how the study was funded, which to me suggests that the drug company funded it. If that is the case it does call into question the results so would really need an independent study.

      The main thing now is for the effects to be replicated in other clinical trials. The only other trial is translated here (haven't searched it yet) http://translate.googleusercontent....500012&usg=ALkJrhh3XlzCc5_nyNMfiZDH0PwrVZwxbg

      They do say that the best results were for those who had tinnitus for a short time, so maybe the next trial needs to only have people who have had it for a year or more to rule out those who will get better in those early stages, especially with the help of a medical intervention.

      It would be interesting to see only the results for those with chronic tinnitus, to see if there was any statistical significance for them. This would certainly give good proof for the drug.

      The drug also doesn't appear to be too bad http://www.patient.co.uk/medicine/Acamprosate.htm and http://www.netdoctor.co.uk/alcohol-abuse/medicines/campral-ec.html

      Could be positive.
       
    30. Steve H
      Creative

      Steve H Director Staff Benefactor Team Trobalt Team Tech Team Awareness Team Research

      Location:
      York, UK
      Tinnitus Since:
      2003
      Cause of Tinnitus:
      Flu, Noise-induced, Jaw trauma
      These are highly addictive though and can leave you in a far worse state when you try and withdraw from them. I can't see any references to addiction to acamprosate, not to say there aren't any of course.
       

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