Acousia Therapeutics

Regain project

https://www.actiononhearingloss.org...omise-of-new-treatments-for-hearing-loss.aspx

 

Apparently I have been living under a rock. With all the time I spend online reading about hearing loss(research) I don't know how I missed the REGAIN PROJECT. Brightens your day when you see news like this.

 

@Samir

In Germany it sounds good, do you think you must have a German citizenship to participate ?

 

Wow I've never heard about this project !

Is it like FX / Genvec with regrowing hair cells ?

Phase 2 during the end of 2017 ? It's so exciting, is it as promising as FX ?

 

At the bottom of the blog it says another blog coming out end of month from researchers/clinicians running REGAIN trial which will provide more info regarding how you can take part.

 

You can always come by and pick me up

 

If Frequency and Regain both are preforming clinic trials in 2018 that would make 2 concurrent hearing regeneration human trials. How many human hearing regeneration trials have ever taken place? Genvec would count as 1. Has their been any others? Does seem like a changing tide in terms of treatments. My one grip would be that synaptic focused companies don't have the urgency or effort that hair cell companies do.

 

That's reallyyyyyyy coooooool.

I mean, it seems like now we know that regrowing hair cells is the BEST way to cure tinnitus.

I remember about Auris failure, but it was an old process based on old papers.

Now it's litteraly booming, like all companies are working as fast as they can to be the first on the market.

I bet that by the end of 2017 with EU trial, if it works the others companies like FX and Genvec will accelerate their work.

 

How do we know that ?
Obviously this is awesome news , but we have no proof at all that this will cure tinnitus.

 

Didn't expect this at all! Good news!

 

right. It's pretty well documented that over a long period of time, chronic tinnitus causes gray matter density changes in the brain. In some cases this is actually tissue growth, but the thing most associated with tinnitus distress afaik is gray matter loss in the right anterior insula.

So, there's a question of to what degree the brain will repair itself, if hair cell loss is truly reversible. Only one way to find out....

 

Because our current knowledge shows that regrowing hair cells is the current best way to cure T.

 

Hypeeee

 

From the blog post it looks like the treatment will turn supporting cells into new hair cells, so if new supporting cells don't grow after the treatment it might compromise the treatment of Frequency Tx which needs supporting cells.

 

I am really happy that Phase II is scheduled to follow Phase I so quickly, bodes well. The race is on

 

If you follow Audion, this isn't exactly news. The problem is that this approach directly differentiates existing SCs into HCs so it results in a loss of SCs.

 

So why didn't we hear about REGAIN/ACOUSIA before today ?

It has a high chance to cure tinnitus induced by noise and we'll have phase 1 result before 2017 (and maybe phase 2) !

I still don't get why we are overtalking about FX, Genvec... But this project did start around 2015 and phase 2 before 2018 !

 

I had heard of it before today.

We certainly don't know the possibility of success (for either hearing loss) before a Phase 1 trial. (For FDA trials, the probability of moving from Phase 1 to 2 is is a bit less than 2/3, and the probability of moving from phase 1 to approval is < 10%.) Moreover, the schedule of a phase 2 trial will depend on the results of the phase 1 trial and the regulatory agencies. The company does not set the actual schedule.

The project may have started in 2015, but the underlying results are from 2012 or 2013.

 

It's only your purcentages dude, but I'm really hopeful since they prepare Phase II right after Phase I (means that it will succeed).

- If Phase I and II succeed the treatment will be on the market 1 or 2 years after.
- If it doesn't succeed like it was planned, others companies will learn about it and go faster.

It's all good man

 

After a phase II you have to run several phase III and some of them need quite a large number of applicants. So not one or two years after.

Either way we'll know about the efficency of this treatment quite soon (end of next year pronabl)

 

Oh my days! Am I reading this right? Trial in London!

I was wondering what has happened to the Regain project. This is great news to us deaf/ hard of hearing people.

I am scheduled for cochlear implant removal surgery in the next few weeks (right ear). My question is after implant removal would this therapy work? As it requires supporting cells to be turned into hearing cells. How would this work on an profound ear? I can always go for my left ear which has severe HL.

I would rather wait and apply for the phase 2 trial as phase 1 is merely concerned with safety issues regarding the therapy.

I live 90 mins away from London and I will definitely get in touch with the clinical team. Eagerly waiting for next months blog

 

Do you mean our current guess is that this is the best way to cure T ?
There is no proof of that , not that I am aware of.

 

This project seems promising! As Razah said don't know if it will cure T for those who have some hearing loss , but we don't know if it won't as well 50/50 ...

 

You're right. Curing tinnitus by restoring hearing is only just a hypothesis. But it's the best shot we got so far. And a lot of bright minds support this hypothesis.



At the very least, if restoring hearing doesn't diminish tinnitus then tinnitus researchers can strike this off their list and focus on researching other methods for a cure.

 

It may also be good to hear again with or without tinnitus