Antidepressants (SSRIs, SNRIs, MAOs, TCAs, TeCAs)

Um, what are potassium channel modulators??

 

"Tinnitus is thought to arise from neural hyperactivity. As potassium ion channels play an important role in regulating the resting potential and spontaneous and evoked neural activity, potassium channel modulators may represent potential therapeutic targets for tinnitus therapy. Potassium channel modulators have also attracted attention as potential therapeutic targets for pain, epilepsy, anxiety and other hyperexcitability disorders (148, 149). In a preliminary report utilizing a rat behavioral model, the potassium channel modulators flindokalner (BMS-204352; MaxiPost™), and its (R)-enantiomer (R-MaxiPost™) reduced behavioral evidence of salicylate-induced tinnitus in a dose-dependent manner (150). Both enantiomers are KCa1.1 (BK) positive modulators and Kv7.1 negative modulators (149, 151). MaxiPost and its (R)-enantiomer modulate Kv7.2-Kv7.5 ion channels positively and negatively, respectively. These results suggest that potassium channel modulators may represent new therapeutic candidates for tinnitus management."

 

When I was on Amitriptyline the dose I was on was 50mg. It worked at that dose so in my case there was no reason to increase it. It also did away with my daily headaches.

 

Don't make this wrong if your T stopped with trobalt + cat's claw avoid amitriptyline is ototoxic.

 

I know...Sad isn't it?

 

MY T/H were caused my a regimen of ssri' and Cipro. 3 years later Im a mess. Ive battled dont drink dont smoke
eat well exercise all right. The conclusion that strikes me is I have to get off these drugs to have any kind of life.
I want to taper off Venlafaxine see how the T/H work out.

 

Ive never meet a doc who fessed up about any med. Why would they, they push the stuff.
You have anxiety and depression what do you get from an MD? Im really fighting for my life.
Recently went to another shrink. She gave me Oxcarbezapine saying it will tame your tinnitus.
It messed my up, crying for three weeks. Less sleep more T/H. They have huge egos never admit any
wrong doing.

 

I would have to say that people should avoid every drug there is because none of them are 100% safe.

 

I would be EXTREMELY careful with these kind of meds.

I got my tinnitus from a single 75mg dose of trazodone / trittico. Never had any ear or tinnitus problems before (tbh I didn't even really know or care what tinnitus was). I took a single pill before going to sleep (got more or less knocked out by the trazodone), and woke up with my BRUTAL 11/10 tinnitus that hasn't stopped almost 3 years later.

It's funny really, the trazodone was prescribed because I had some (slight) problems with insomnia and it ended up giving me super-insomnia (thanks to this relentless screeching in my head). Oh well.

 

Every one of these drugs report T as side effect..yet when your mental health is going down the toilet, what do you do?

I'm surprised you have docs that care enough to look. Mine sure don't!

 

with that said. .anyone try wellbutrin?

 

yeah, dr.nagler

 

implying his T resulted from wellbutrin? I thought it was hearing loss? @Dr. Nagler did wellbutrin give you T?

 

I tried Wellbutrin at first and it did not help me in any way. When I finally tried Amitriptyline it helped a great deal with my sleep.

 

Maybe this has been discussed here a thousand times, if it has sorry.

The question I have is, is there anyone that has gone off any of these drugs after a extended period of time and experienced a reduction in their tinnitus or hyperacusis?

 

There does not seem to be a single f"§§§%ng antidepressant that does not have T as a possible side effect....
T is much more bearable when I dont feel exhausted, depressed or anxious. From that aspect one would think that maybe antidepressant medication could be the solution to this seemingly unsolvable problem.
On the other hand though it was Citalopram that gave me this torturous present... I would be an idiot to start another antidepressant and taking the risk of worsening an already horrible T, wouldnt I?

 

Yes don't go that road. I will not go it either.

 

Remeron is a common AD on this forum and people have had good results using it

 

Probably the best thing I've read at TT.

 

I did, and noticed an increase, stopped right away, after 1-2 pills. Christian78 had a very noticable worsening from it which never went down.

 

="inadmin, post: 102614, member: 1113"]I did, and noticed an increase, stopped right away, after 1-2 pills. Christian78 had a very noticable worsening from it which never went down.[/QUOTE]

Thanks for your post and sorry to hear about Christian78

 

Tinnitus became problematic for me in 1991 and in 2001, after some noise exposure and a flare up in my tinnitus, stressed out and at my wits end, I went to my GP, whom I had brought up my issues with tinnitus and he gave me a script for Paroxetine (Paxil) 10mg.
After an adjustment period of a few weeks where I got used to the Paxil, I continued on for a number of months and did find that the Paxil, even at that fairly low dose did help me ignore the tinnitus more easily.
Unfortunately, I then got into a relationship which quickly became dysfunctional (partly my fault, partly hers) and after a breakup and emotional trauma (long story) my dose on Paroxetine became 20mg.

Over the years, Paroxetine has been useful, BUT it can be and is a very difficult to come off and has a number of well documented withdrawal symptoms.

So, despite my efforts, now in 2015 I am still on 20mg daily of Paroxetine.

 

any experience with Cymbalta, Valdoxan ? zoloft was bad for me . what the best for sleep ? taking lorozepam 1.25 and half Valdoxan for slepp. but not feeling good . nor sleep very ok- ok i have 6 hours of it .

 

I should have done more research. Remeron and Trazodone are both ototoxic and I would not recommend them to anyone on this board. I am off Remeron for good. I will never go near that stuff again. I am trying to wean myself off Trazodone, but it's been an awful and difficult withdrawal period. If you don't need to go down this road, don't. And, don't ever, ever take your doctor's word for it.

 

Hi Michael. I am currently tapering Trazadone very slowly. If you don't mind, can you tell me what your withdrawal symptoms are like?

 

I am down to 12.5 mg and have to say, I am all over the map, since I am withdrawing from Remeron and Trazadone. I am feeling terrible anxiety, moodiness, weight loss and many of the other ones mentioned. I keep reminding myself that each day it will get better. Only way to get through it.

 

I'm down to 25 Trazadone from 75. I noticed that once I got to 25 the mood swings stopped. I am still taking 7.5 Remeron. How was that withdrawal? I hear that's harder to taper. Any T changes with tapering?

 

To be honest, no. My T has not changed at all. I've been told it gets worse when you're withdrawing, which is what is happening right now. I'm hoping it's going to even out soon. I found getting off Remeron was not all that hard, but I hadn't yet tapered off Trazodone yet, so my experience would be different from someone just tapering off Remeron. I'm glad to hear of your experience. It gives me hope, because the mood swings and anxiety are wearing me (and my wife) out.

 

This is very interesting. I am basically doing the reverse of what you are doing. I'm tapering Trazadone first, and next is Remeron. You tapered Remeron first, now you're tapering Trazadone. I am going very slowly, I'm 9 months into my taper. The reason being, I don't want to hit a wall on insomnia that I can't get past. Also T spikes. I had a couple that lasted a few minutes that were super loud and made me nervous to say that least. But I've read T spikes can happen when tapering. May I ask how fast did you taper the Remeron? You might be having the mood swings and anxiety as a combination withdrawal effect from both meds. I've done a lot of reading and these symptoms can crop up a month or more of being completely off an AD. Try getting as much exercise as possible. Gives you a nice seratonin boost and calms your anxiety.

Hang in there, it will get much better.

 

I'm pretty sure much of my problem is indeed from Remeron withdrawal, which I stopped cold turkey. I am tapering off Trazodone much more slowly now. I am up against an insomnia wall and have been struggling with the associated anxiety. But now that I recognize what's likely going on, I am going to put together a plan and stick with it. But, my goodness, does this ever feel awful.