Audion Therapeutics Trial

Discussion in 'Research News' started by Aaron123, May 20, 2017.

    1. Manny
      Dead

      Manny Member Benefactor Hall of Fame

      Location:
      United States
      Tinnitus Since:
      1/2018
      Cause of Tinnitus:
      central gain << NIHL
      What makes you guys say that?
       
      • Good Question Good Question x 4
    2. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
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    3. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      If you check the link and scroll down you will find:

      "The results of the phase I and II REGAIN studies will be published after the completion and data analysis of both studies; we are aiming for early 2020.".
       
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    4. Barber27

      Barber27 Member

      Tinnitus Since:
      1998
      Cause of Tinnitus:
      Load noises
      They are now recruiting for phase 2 trials. They have emailed me and asked for a telephone interview to see if I would be eligible. Will probably do interview etc to see I can get more information but I doubt I'd actual do trial if accepted
       
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    5. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      why wouldn't you?
       
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    6. Barber27

      Barber27 Member

      Tinnitus Since:
      1998
      Cause of Tinnitus:
      Load noises
      I'd be scared of it failing and losing more hearing which I really really don't want!
       
      • Agree Agree x 1
    7. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      is that a real risk?


      I don't see how you can lose hearing?
       
      • Good Question Good Question x 1
    8. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      If the substance is improperly stored or handled and an infection sets up. I think that's unlikely but still possibly a risk, one I'd gladly take
       
      • Agree Agree x 1
    9. Barber27

      Barber27 Member

      Tinnitus Since:
      1998
      Cause of Tinnitus:
      Load noises
      Having hearing loss is worse than tinnitus.....I have both and had tinnitus before my hearing dropped to the current low levels
       
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    10. Benoves

      Benoves Member Benefactor

      Tinnitus Since:
      26-9-2017
      Cause of Tinnitus:
      Unknow possibly noise trauma
      That's not always the case. I was totally completely fully habituated to my 40 dB hearing loss for 25 years until I got tinnitus and it got me suicidal for a very long time. I didn't even wear hearing aids for 25 years.
       
    11. Johan_L

      Johan_L Member

      Location:
      Sweden
      Tinnitus Since:
      05/2015
      Cause of Tinnitus:
      Noise induced
      Everything we do in life is a calculated risk, even just leaving our homes. I've realized that I have a much higher risk of getting into an car accident as my earmuffs reduce my hearing... (I have H)

      If there was a drug with 50% chance of getting better and say 2% risk of infection/getting worse I'd take it any day.
       
      • Agree Agree x 2
    12. Krolo

      Krolo Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999 , Worse in September 2018
      Cause of Tinnitus:
      Loud Volume
      Hopefully someone on TT who lives in the UK can get into this trial. Since it's only open to UK citizens.
       
      • Agree Agree x 3
    13. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      The Audion Regain trial promises efficacy results from Phase II in early 2020.

      If it proves successful (always IF) and 2020 into 2021 is the Phase III period, I'm wondering if anyone knows what the process is in Europe to bring a treatment to the clinic.

      Is it the same as the US FDA's? Is it as longwinded and bureaucratic? Or do the Europeans do things a little differently?
       
      • Good Question Good Question x 1
    14. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      We do things differently in Europe.

      Look up the timeline so far for this thing called Brexit.

      After millions and millions... valid arguments on both sides... we will probably never come to an agreement... so we’ll probably abandon the thing altogether. Or remain in limbo indefinitely.

      I sincerely hope this will not be the case for Audion. But I have more confidence in FX. When there’s money to be earned, you can always count on the US. Which is a good thing here.

      On a more serious note, I am not familiar with the procedures here. I will send our Belgian minister of health a mail tomorrow to find out.
       
      • Agree Agree x 1
    15. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      Actually, wasn't it your Prime Minister that suffered a hearing injury as result of some kind of noise accident? I recall seeing news footage, perhaps even posted here on TT a couple of years ago.

      One would think he would now be personally invested in ensuring Audion moves as fast as possible to market. At least in Belgium anyway!
       
      • Agree Agree x 1
    16. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
    17. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      You got a link?
       
    18. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      • Like Like x 1
    19. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      As a Brit @Paulmanlike, you have the opportunity to participate in the Audion trial if you wish. They're keen for numbers.
       
    20. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      Yes, he went to the same hospital / hyperbaric oxygen chamber as me. University hospital of Antwerp.
       
    21. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      And was it helpful?
       
      • Good Question Good Question x 1
    22. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Just checked it out, thanks. I had a 30 dB loss in 6 kHz range but I will get retested next week to confirm it. Interesting in the comments they will be looking at any effect on tinnitus as well.
       
      • Agree Agree x 1
    23. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Jeez this whole hearing regeneration is movingly faster than expected. I hope they will also publish the results if it cures tinnitus as well, and it’s safe, then it’s just a waiting game. I suppose until then, we have Neuromod working on bimodal neuromodulation to keep the noise down whilst this thing comes out. I expect if it’s successful to be on the market no later than 2023.

      Click laughing face if you’re reading this in 2023 and they still haven’t figured it out.
       
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    24. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      I don’t know... I don’t hang out with the guy
       
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    25. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      No, I meant you!
       
    26. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      I must say that I really like Action On Hearing Loss as an organisation too. They seem to have their fingers in so many pies.

      They're not just about counselling, rehabilitation and publicity, but they also fund seminal and ongoing research into treatments and cures for hearing loss and tinnitus all over the globe. I'm not sure if they've received much attention on TT (perhaps they have over the years), but they seem to be the type of organisation that many people on TT wish the BTA and the ATA were. Admittedly, they're of longer standing and maybe better funding. They appear very worthy of our support.
       
      • Agree Agree x 2
    27. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      I got my first HBOT three weeks after the noise induced trauma and because the meds did not resolve my T completely.

      Five weeks after HBOT my mild tone was reduced to a static hiss which I only heard in silent surroundings. The weeks after the sessions my ears were itching deep inside, like a wound that’s recovering... I cannot tell whether it was HBOT or my own body healing...

      I personally do believe it can help your body heal, but only in the first few weeks.

      Unfortunately, my T increased again after two incidents:

      1) high pressure cleaning with lousy earplugs

      2) one pill of trazodone which made me freak out and which “moved” my static ear-tinnitus to a sharper head tinnitus.
       
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    28. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
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    29. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      Audion is running at the same pace as Frequency. If they're successful, here's hoping perhaps they could hit the market first. Certainly in Europe without all the FDA red tape.
       
      • Agree Agree x 1
    30. Striveon

      Striveon Member

      Tinnitus Since:
      08/2018
      Cause of Tinnitus:
      Unknown
      Will this help cure chronic tinnitus?
       
      • Good Question Good Question x 1

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