Audion Therapeutics Trial

Discussion in 'Research News' started by Aaron123, May 20, 2017.

    1. Drone Draper
      Jaded

      Drone Draper Member

      Location:
      U.K.
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      NIHL, ETD and work stress
      They'll only do the treatment in one ear, so that's not a problem. If you have hearing loss in both, they'll use the worst one.
       
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    2. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      Got an email from them. They only take US citizens. Why do they have trials in London then??
       
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    3. Drone Draper
      Jaded

      Drone Draper Member

      Location:
      U.K.
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      NIHL, ETD and work stress
      I don't think that's right.

      "At least 40 people will take part in this second part of the study in total and the study will be conducted in the United Kingdom, Greece, and Germany."

      Doesn't look like they're looking for American participants at all.
       
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    4. gadsie
      Angelic

      gadsie Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Normal volume headphones/clubbing with earplugs
      Thank you for your email. Unfortunately, we are only able to recruit UK citizens for the early phases of the trial.


      Any updates on the trial will be available http://regainyourhearing.eu

      :(
       
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    5. Drone Draper
      Jaded

      Drone Draper Member

      Location:
      U.K.
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      NIHL, ETD and work stress
      Damn.

      Give them my address lol :ROFL:
       
    6. gadsie
      Angelic

      gadsie Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Normal volume headphones/clubbing with earplugs
      I don’t understand why, really. I even said we could pay for travel expenses etc. ourselves (because on the website they mention they cover that). Oh well..
       
    7. gadsie
      Angelic

      gadsie Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Normal volume headphones/clubbing with earplugs
      Haha, guess that could work.
       
    8. gadsie
      Angelic

      gadsie Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Normal volume headphones/clubbing with earplugs
      Does anyone here know if it could work to just give a fake address, or a PO box or something? I don’t see why they would ever really need that in practice. (Hypothetically, of course)
       
    9. Drone Draper
      Jaded

      Drone Draper Member

      Location:
      U.K.
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      NIHL, ETD and work stress
      It is a weird thing. Also Audion Therapeutics is a Dutch company, after all. Why couldn't they take a resident from the country they're based?

      Maybe they need you to be registered with the NHS or something, I'm reading through the Participant form I recieved and there's nothing that denotes that you need to be a UK resident.

      You would probably be able to just give them a fake address, I doubt they're going to look through your credit records or electoral register to verify your identity.

      One thing though, they also say they need to be able to contact your GP.

      "With your permission, your GP will be notified that you are taking part in this study and the details of the tests involved and any important changes in your hearing or health. Your GP will be able to contact our team easily if they have any concerns or queries relating to your involvement in the trial."

      So it might be hard to get that one past them.
       
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    10. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      I meant to say UK citizens as well :( I read it wrong. Sorry!
       
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    11. Philip83
      Jaded

      Philip83 Member Benefactor

      Location:
      Swede living in Austria
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Noise trauma from loud moped (2001) Noise blast (2014)
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    12. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
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    13. AUTHOR
      AUTHOR
      Aaron123

      Aaron123 Member

      Tinnitus Since:
      00/0000
      Cause of Tinnitus:
      Irrelevant
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    14. Philip83
      Jaded

      Philip83 Member Benefactor

      Location:
      Swede living in Austria
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Noise trauma from loud moped (2001) Noise blast (2014)
      I know, just thought I'd share that there were some press about it.
       
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    15. Philip83
      Jaded

      Philip83 Member Benefactor

      Location:
      Swede living in Austria
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Noise trauma from loud moped (2001) Noise blast (2014)
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    16. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      Might be kind of hard when they ask to see your passport.
       
    17. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      Within the next two years surely we'll know whether we are or not.
       
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    18. Drone Draper
      Jaded

      Drone Draper Member

      Location:
      U.K.
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      NIHL, ETD and work stress
      My understanding is you just need to be a resident, not a citizen. Almost half of London where the trial is are not British citizens.
       
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    19. Rubenslash

      Rubenslash Member

      Location:
      Brussels
      Tinnitus Since:
      04/2016
      Cause of Tinnitus:
      Several
      As per Audion therapeutics:

      Other interesting quotes:

      => It means they believe it could still work after 20 years of damage, that's a very good sign.

      Not only limited to noise induced hearing loss
       
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    20. Terminator

      Terminator Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Sound trauma
      Let's hope it does not take them 20 years to take this stuff mainstream.
       
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    21. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      "up to 20 years duration".
      That gives me hope I needed. If it does not eventuate, at least I benefited from this hope.
       
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    22. síocháin

      síocháin Member

      Tinnitus Since:
      04/2016
      Cause of Tinnitus:
      Noise
      The rumour in the music community here was this person was doing much better with his tinnitus and hyperacusis and could work with music again like before. I managed to get in contact with him and turns out he has been a part of the Regain Project trials.

      He said he unfortunately wasn't allowed to tell me much about it, but that he had some gel-like medicine injected in his ears, and it had helped him a lot. He used those words!

      And also I see he is touring again, which really is a good sign!

      Just wanted to post it on the forum, cause it sure made me hopeful for some relief in the near future!
       
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    23. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      A detective should be able to find out who this person is :).
      On a more serious not: if something like inner ear regeneration in a person happens, how is he or she able to keep this a secret? Especially going form not touring anymore because of hearing issues to touring again.
       
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    24. Chinmoku

      Chinmoku Member

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknown, possibly medication
      This may have been written before. While I was waiting in an hospital for a ent appointment a few weeks ago, I read a notice on the wall about the Regain project. They were looking for volunteers but they said explicitly that if one was bothered more by tinnitus then by hearing loss then this person would not have been suitable. This bothers me. Could the treatment worsen tinnitus?
       
    25. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      From @síocháin's post it seems to be that it doesn't since the musician was able to play music again. If this is actually true and this person did get his tinnitus and hyperacusis reduce I believe FX-322 can do the same thing.

      At this rate it seems like Regain/Audion is ahead. Phase 2 results will be published next year and hopefully they go straight into Phase 3. On the other hand Frequency Therapeutics hasn't started Phase 2a and they are most likely going to have a Phase 2b.
       
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    26. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      I think they didn't want to muddy the waters too much. Their focus is on hearing loss. Someone asked them if there was a chance that their drug could cure tinnitus. Their response:

      Dear Fabien,

      The drug we are testing in the REGAIN trial is aimed at regenerating inner ear hair cells and restoring hearing in people who have acquired hearing loss later in life. With hearing loss and tinnitus closely linked, we will be monitoring the effect of the drug on tinnitus as well. Worldwide trials of novel drugs for tinnitus are being initiated; it is too early to tell if they will cure tinnitus.
       
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    27. Enclave

      Enclave Member

      Location:
      Meh
      Tinnitus Since:
      Meh
      Cause of Tinnitus:
      Meh

      The drug isn’t a gel-like substance, it’s a liquid:

      “This is the first time the study drug LY3056480 will be tested in people. The study drug is a liquid that must be delivered to the inner ear, through the eardrum using a syringe.”
       
    28. Philip83
      Jaded

      Philip83 Member Benefactor

      Location:
      Swede living in Austria
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Noise trauma from loud moped (2001) Noise blast (2014)
      I think these are irrelevant semantics. There are also products that call themselves "liquid gel". What is that then? :rolleyes:
       
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    29. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      It almost has to be a gel. If it was a low viscosity liquid it would immediately flush out through the eustachian tubes without plugging them first.
       
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    30. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      It sound very positive if they have enough confidence to inject both ears.
       
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