Audion Therapeutics Trial

Discussion in 'Research News' started by Aaron123, May 20, 2017.

    1. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      Sorry, I have scanned the above posts, where is this? I'm probably being blind lol, today had been bad.
       
    2. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      ... gel-like medicine injected in his ears,
       
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    3. Mathieulh
      No Mood

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      It's most likely a gel, because that's what makes sense from a practicality standpoint, although there are a few maneuvers one can do to temporarily close the Eustachian tubes, of course that would rely on the patient performing those, so using a gel would be more efficient.
       
    4. Mathieulh
      No Mood

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      Not to sound like a party crasher, but I am definitely not using this unless I am desperate, so many things can go awfully wrong by messing with potassium ion channels, it's not like the drug can target a specific area in the brain, so it has to be broad to some degree, that's enough to cause potential serious (and irreversible) side effects to a lot of people. There is a reason Trobalt was eventually discontinued.
       
      • Agree Agree x 3
    5. Mathieulh
      No Mood

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      I don't like how they exclude tinnitus patients from their trial, there are patients with objective hearing loss that have tinnitus, excluding those means we will have no data whatsoever on the impact of thus drug on tinnitus.

      Sadly, I don't fit the criteria for this trial as I have no perceivable hearing loss and use no hearing aid.
       
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    6. Mathieulh
      No Mood

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      It's not the stereocillia that tinnitus sufferers have to worry about, it's the underlying peripheral neuropathy, this is what causes the tinnitus, whereas damaged/dead stereocillia only cause hearing loss, this is why most people experience some form of hearing loss without tinnitus, it has nothing to do with our brains being different and everything to do with the type of damage sustained.

      Of course restoring sterecillia alone isn't going to achieve much if it's not attached to a nerve ending, restoring the nerve would actually get rid of the noise, (without restoring hearing itself) whereas restoring both the nerve and stereocillia would let people get their hearing back and heal tinnitus.

      Of course if you don't have tinnitus, this means your nerve is still fine and restoring stereocillia alone would indeed fix your hearing to some degree.
       
      • Informative Informative x 2
    7. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      I think I am am optimist, but I struggle to envisage them treating both ears in direct contradiction of the stated trial criteria and control? Not arguing with other aspects of statement though.

      Can we ask a follow up question?
       
    8. Enclave

      Enclave Member

      Location:
      Meh
      Tinnitus Since:
      Meh
      Cause of Tinnitus:
      Meh
      This individual’s anecdote is here-say, and this anecdote is supported by an “anonymous source”, and within this anecdote there exists inaccurate information.

      This is what I’m pointing out. Semantics are important, but go ahead and believe everything that you read.
       
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    9. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      Of course, but ask @síocháin, she is the source of the story and can clarify.
       
    10. Lucifer

      Lucifer Member Podcast Patron Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      http://www.isrctn.com/ISRCTN59733689

      They changed the publish date for Phase 2 results from 31/01/2020 to 30/04/2020. But at this stage it still seems Audion is way ahead compared to Frequency Therapeutics.
       
      • Informative Informative x 3
    11. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      31-1-2020 was mentioned on the site for a few years. Else they mentioned early 2020.
       
      • Like Like x 1
    12. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      Does somebody know of any results from pre-clinical tests of LY3056480 ?
       
      • Good Question Good Question x 3
    13. Lucifer

      Lucifer Member Podcast Patron Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      Not that I'm aware of. The only person we know who has success with this drug is through a mutual friend of @síocháin.

      @síocháin do you know whether your mutual friend is part of Tinnitus Talk and is willing to tell us about his experience from using the drug?
       
      • Good Question Good Question x 4
    14. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      So if these reports are true then this is it. The treatment for hearing loss and tinnitus exists.
       
      • Agree Agree x 4
    15. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Seriously, if these anecdotes are true, which they probably are, then our redemption is sitting on shelves in lab supply companies. The barrier to having our lives restored is now government red tape.


      Completely unacceptable.
       
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    16. Lucifer

      Lucifer Member Podcast Patron Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      @JohnAdams I believe the drug works. Who's going to release it first, I reckon Regain.
       
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    17. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      We need to somehow think of a way to make this available sooner. If possible.
       
      • Agree Agree x 5
    18. Lucifer

      Lucifer Member Podcast Patron Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      I agree. If it works now and has no side effects it should be released as soon as possible.
       
      • Agree Agree x 1
    19. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      when they were testing ly411575 on rodents, first they experimented with oral administration at a much higher dose. It caused their hair to fall out, their skin turned green and they got skin tumors.
       
    20. Lucifer

      Lucifer Member Podcast Patron Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      It worked better when it was injected in the ear and had fewer side effects. Hopefully results are positive again next year with Phase 2 data so they can speed up the process.
       
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    21. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      yeah that's the entire point with injecting it into the ear. we should be very thankful that there is a semipermeable membrane to the inner ear.
       
      • Agree Agree x 4
    22. John Queen

      John Queen Member

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown
      Well, until they get the drug approved... Meanwhile in Korea, Russia, China and a few other countries after Phase 2 results will be published:
      3ayl9v.jpg
       
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    23. ThomasC
      Lonely

      ThomasC Member Benefactor

      Location:
      France
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      hearing loss
      So, if i understand, they have already cleared phase 2 , and will publish the results next year.
      Any idea when they will start the third phase ?
       
    24. Lucifer

      Lucifer Member Podcast Patron Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      I don't think they are done with Phase 2 yet. Results will be publish end of April 2020, originally it was end of January 2020. I assume once they publish results hopefully they move onto Phase 3. Now there is some good competition between Regain/Audion and Frequency Therapeutics.
       
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    25. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      so here we have the closest hope of a cure for our situations and there is very little excitement. absolutely pathetic.
       
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    26. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I predict massive excitement in April if phase 2 results are good.
       
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    27. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Some, like, government people need to feel sorry for us and get them to hurry up.
       
      • Agree Agree x 1
    28. Auron
      Dead

      Auron Member

      Location:
      Planet Earth
      Tinnitus Since:
      Spring
      Cause of Tinnitus:
      Acoustic Shock
      Excitement from whom?Us,here on the forum?
       
    29. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      in part, yes
       
    30. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Kv3.1 channel drugs would be pretty specific for the auditory system since that type is at a much higher concentration there (including auditory brainstem, which can be affected by some ototoxins). Probably would have less side effects than the broad spectrum channel opening drugs, too.

      On its own, KV3.1 drugs could help hearing but is probably less effective for tinnitus on its own based on Autifony's failed tinnitus trial. Different ion channels (or different formulation or drug) may be a different story.

      Personally, Kv3.1 drugs have the potential to help my hearing immensely since I likely have both cochlear and brain stem involvement but I'm not sure if I would be the norm there. I do see more mild and more targeted channel drugs as helping a lot of people with various conditions, though.

      Edited to add: most tinnitus targeted channel opening drugs are being tested on different channel types than kv3.1.
       

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