Audion Therapeutics Trial

Discussion in 'Research News' started by Aaron123, May 20, 2017.

    1. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      Sorry, I have scanned the above posts, where is this? I'm probably being blind lol, today had been bad.
       
    2. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      ... gel-like medicine injected in his ears,
       
      • Agree Agree x 1
    3. Mathieulh
      Busy

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      It's most likely a gel, because that's what makes sense from a practicality standpoint, although there are a few maneuvers one can do to temporarily close the Eustachian tubes, of course that would rely on the patient performing those, so using a gel would be more efficient.
       
    4. Mathieulh
      Busy

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      Not to sound like a party crasher, but I am definitely not using this unless I am desperate, so many things can go awfully wrong by messing with potassium ion channels, it's not like the drug can target a specific area in the brain, so it has to be broad to some degree, that's enough to cause potential serious (and irreversible) side effects to a lot of people. There is a reason Trobalt was eventually discontinued.
       
      • Agree Agree x 3
    5. Mathieulh
      Busy

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      I don't like how they exclude tinnitus patients from their trial, there are patients with objective hearing loss that have tinnitus, excluding those means we will have no data whatsoever on the impact of thus drug on tinnitus.

      Sadly, I don't fit the criteria for this trial as I have no perceivable hearing loss and use no hearing aid.
       
      • Like Like x 1
    6. Mathieulh
      Busy

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      It's not the stereocillia that tinnitus sufferers have to worry about, it's the underlying peripheral neuropathy, this is what causes the tinnitus, whereas damaged/dead stereocillia only cause hearing loss, this is why most people experience some form of hearing loss without tinnitus, it has nothing to do with our brains being different and everything to do with the type of damage sustained.

      Of course restoring sterecillia alone isn't going to achieve much if it's not attached to a nerve ending, restoring the nerve would actually get rid of the noise, (without restoring hearing itself) whereas restoring both the nerve and stereocillia would let people get their hearing back and heal tinnitus.

      Of course if you don't have tinnitus, this means your nerve is still fine and restoring stereocillia alone would indeed fix your hearing to some degree.
       
      • Informative Informative x 2
    7. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      I think I am am optimist, but I struggle to envisage them treating both ears in direct contradiction of the stated trial criteria and control? Not arguing with other aspects of statement though.

      Can we ask a follow up question?
       
    8. Enclave

      Enclave Member

      Location:
      Meh
      Tinnitus Since:
      Meh
      Cause of Tinnitus:
      Meh
      This individual’s anecdote is here-say, and this anecdote is supported by an “anonymous source”, and within this anecdote there exists inaccurate information.

      This is what I’m pointing out. Semantics are important, but go ahead and believe everything that you read.
       
      • Agree Agree x 2
    9. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      Of course, but ask @síocháin, she is the source of the story and can clarify.
       
    10. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      http://www.isrctn.com/ISRCTN59733689

      They changed the publish date for Phase 2 results from 31/01/2020 to 30/04/2020. But at this stage it still seems Audion is way ahead compared to Frequency Therapeutics.
       
      • Informative Informative x 3
    11. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      31-1-2020 was mentioned on the site for a few years. Else they mentioned early 2020.
       
      • Like Like x 1
    12. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      Does somebody know of any results from pre-clinical tests of LY3056480 ?
       
      • Good Question Good Question x 3
    13. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      Not that I'm aware of. The only person we know who has success with this drug is through a mutual friend of @síocháin.

      @síocháin do you know whether your mutual friend is part of Tinnitus Talk and is willing to tell us about his experience from using the drug?
       
      • Good Question Good Question x 2

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