AUT00201 — Autifony Therapeutics

Discussion in 'Research News' started by FGG, May 4, 2020.

    1. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
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    2. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Sounds like a doozy of a drug.
       
    3. Sevv

      Sevv Member Benefactor

      Tinnitus Since:
      12.04.2019
      Cause of Tinnitus:
      Loud concert
      The drug will be useless for us if it comes out around the same time as the super specific anti-tinnitus-Tzounopoulos-drug.
       
    4. Croaker
      Haunting

      Croaker Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Unknown
      Does this channel have anything to do with the nerve fibers that cause pain hyperacusis? I’ve read that sodium ion/nav 1.7 blocking would almost certainly work but I’m far from a biochemist so I’m kinda stumbling in the dark here. It’s crazy how far behind neuropathic pain blocking is since it seems like such a huge cash cow. I bet the whole world has had some form of persistent nerve pain for one reason or another.
       
    5. AUTHOR
      AUTHOR
      FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I'm going to write them and find out what this particular drug does for "hearing disorders". KV3.x channels are involved with auditory processing and have to do with phantom sounds in schizophrenia but i know they believe it will be more useful generally too. I don't know more than that but I'm trying to find out.

      I think it has much more potential for tinnitus and loudness hyperacusis though, off hand. I'm not sure it would be helpful for noxacusis.
       
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    6. AUTHOR
      AUTHOR
      FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      It's about 2 years ahead.
       
    7. ThomasC
      Lonely

      ThomasC Member Benefactor

      Location:
      France
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      hearing loss

      and Tzounopoulos-drug is 10 years ahead
       
    8. AUTHOR
      AUTHOR
      FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I meant this drug has about a 2 year head start because it's scheduled to finish phase 1 later this year.
       
    9. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      Interestingly, Xenon Pharma which is also in clinical trials for a redesigned Retigabine is also in the pre-clinical stages of developing Nav 1.7 inhibitors for pain relief.
      https://www.xenon-pharma.com/product-pipeline/
      The drug that is furthest along in their pipeline is about to start Phase 3 clinical trials and another of their drug candidates in phase 2 is indicated for 'orphan neurological conditions'. I'm planning on emailing them later this week to get some more info and to ask whether their drugs would potentially have any utility in treating auditory conditions like tinnitus and hyperacusis.
       
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    10. Croaker
      Haunting

      Croaker Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Unknown
      Makes sense to me. Perhaps calming the other erroneous inputs of the cochlea will indirectly reduce the pain signals, unless their inherent inflammation/irritation has become independent. Since hyperacusis is obviously still influenced by cochlear input (sound) I hope the former is the case.

      You know, all of this science would be very interesting if it hadn’t ruined all of our lives ;)
       
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    11. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      Some additional info:

      They have another Kv3.1/3.2 drugs that is in the process of completing its phase 1 by end of this year - AUT00206 (not to be confused with AUT00201) - which is designated for fragile X syndrome.

      I’m curious how these two compounds differ since they act on the same ion channels and only AUT00201 includes verbiage surrounding “hearing disorders”.
       
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    12. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      According to the Pipeline which is subject to be modified (therefore page catched today), indications are clearly distributed among the two compounds:
      https://autifony.com/pipeline/
      upload_2020-11-5_21-47-14.png

      According to the other pages of their website, it is a little bit confused.
       
    13. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
    14. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      @Frédéric

      I don’t understand what you are saying, sorry? Is there an error with the information or have they done a safety study trial for both AUT00201 and also AUT00206?
       

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