Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

Discussion in 'Research News' started by attheedgeofscience, Sep 19, 2014.

    1. _Patrick_
      Wishful

      _Patrick_ Member Benefactor

      Location:
      Paris (France)
      Tinnitus Since:
      06/2014
      Cause of Tinnitus:
      Unkown
      Well, first of all there is a difference between "helps" and "cures". Of course, maybe in some cases, it does, and I'm glad it did for Danny Boy, but until now, research seem to consider it doesn't work any better than a placebo (and the failure of AUT63 is just about that).
      He doesn't believe much in the AM101 approach either, he said the gel was very slimy, that it was particularly difficult to inject it, and that when people were asked if they wanted to continue with the study most of them refused.
       
      • Agree Agree x 1
    2. amandine

      amandine Member

      Tinnitus Since:
      july 2014
      Danny Boy is not cured.
       
      • Agree Agree x 1
    3. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      Yes, I definitely agree no one has been cured. Off the top of my head, I can't think of too many ailments that have been cured, like polio. A treatment is the best I'm hoping for. Keppra works great for me, as the reactive is what bothers me most, and Keppra stops it.
       
      • Like Like x 1
    4. amandine

      amandine Member

      Tinnitus Since:
      july 2014
      • Informative Informative x 2
    5. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
    6. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
    7. amandine

      amandine Member

      Tinnitus Since:
      july 2014
      • Like Like x 1
    8. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      I can't believe this wasn't / isn't all over the news?! If this can't get airplay, just imagine how important the media thinks T is!
       
      • Agree Agree x 1
    9. Gill Hayes
      Happy

      Gill Hayes Member Benefactor

      Location:
      North West England
      Tinnitus Since:
      Nov 2014
      Cause of Tinnitus:
      Stress I think
      To be honest I don't care how important the media thinks T is as long as the scientist do that's good enough for me !
       
      • Agree Agree x 3
    10. Christian78
      Alone

      Christian78 Member

      Location:
      Gothenburg
      Tinnitus Since:
      (Sep 2013)
      Cause of Tinnitus:
      progressive tinnitus, time of expiring in next 3-6 months
      I will try 101 and 102, and if there is autifony in USA i will get it and try it, i have family in USA...
       
      • Like Like x 1
    11. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      Agreed!
       
    12. Kate Winstol
      Sporty

      Kate Winstol Member

      Tinnitus Since:
      1902
      So this was just wishful thinking what a surprise. It will take a long time before there will be a cure because there needs to be so much more knowledge than there is today.

      There are however some real science on how you can get used to the tinnitus by accepting it.
       
    13. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      Knowledge isn't always necessary. We discovered antibiotics by chance and at the time it wasn't known how it worked or why it worked. The important thing was that it DID WORK. We actually still don't know how aspirin really works and it's been around for almost 100 years. It's still pretty good when you have a headache though.
       
      • Agree Agree x 5
    14. t-man
      Suicidal

      t-man Member

      Tinnitus Since:
      2009
      ...I don't even.
       
      • Agree Agree x 2
    15. truesilence

      truesilence Member

      Tinnitus Since:
      03/2014
      OMG! I few months back I tried to get onto the trial but was rejected because my hearing was normal. I've just received a voice mail from the research department at the Royal National Ear Nose and Throat Hosital asking me to contact them!!!!
       
      • Optimistic Optimistic x 2
      • Good Question Good Question x 1
    16. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      You'll have to let us know what they say! Maybe they have a bunch of sugar pills to get rid of;)
       
      • Funny Funny x 1
    17. truesilence

      truesilence Member

      Tinnitus Since:
      03/2014
      Lol! I hope not!! So strange as I received the call as I was having a consultation with the Neurologist and vowing never to step foot into a hospital again!
       
    18. Gill Hayes
      Happy

      Gill Hayes Member Benefactor

      Location:
      North West England
      Tinnitus Since:
      Nov 2014
      Cause of Tinnitus:
      Stress I think
      Hmm, interesting.
       
      • Agree Agree x 1
    19. truesilence

      truesilence Member

      Tinnitus Since:
      03/2014
      Sorry, was getting my hopes up. It was just a call about my expenses. Oh well....
       
      • Agree Agree x 1
    20. shreddAr87

      shreddAr87 Member

      Location:
      California
      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      loud music...history of anxiety/depression...earplugs idk
      I thought this thing didn't work anyways why are you sad?
       
    21. truesilence

      truesilence Member

      Tinnitus Since:
      03/2014
      Because I stupidly thought it meant that the trial was possibly on again.
       
      • Hug Hug x 2
      • Agree Agree x 1
    22. JohnK
      Busy

      JohnK Member

      Location:
      London
      Tinnitus Since:
      10/26/2015 (habituated) 5/13/2019
      Cause of Tinnitus:
      Ototoxicity and/or stress
      Well, people have spontaneously resolved, but that doesn't count as a cure I suppose...
       
    23. skoupidis

      skoupidis Member

      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma or mvc
      Why shouldn't it? And who exactly is cured? After 1 year? 2 years? Did they take any treatment? The specifics are important...
       
    24. Christian78
      Alone

      Christian78 Member

      Location:
      Gothenburg
      Tinnitus Since:
      (Sep 2013)
      Cause of Tinnitus:
      progressive tinnitus, time of expiring in next 3-6 months
      Autifony is dead, why do we speak about it???
       
      • Good Question Good Question x 2
      • Like Like x 1
    25. JohnK
      Busy

      JohnK Member

      Location:
      London
      Tinnitus Since:
      10/26/2015 (habituated) 5/13/2019
      Cause of Tinnitus:
      Ototoxicity and/or stress
      Indeed they are important but I don't know them. I just hear of people who spontaneously got better.
       
      • Agree Agree x 1
    26. Champ
      Woot

      Champ Member Benefactor

      Location:
      Boston, MA
      Tinnitus Since:
      01/2013
      Cause of Tinnitus:
      Acoustic trauma from headphones
      Yeah there's plenty of other avenues on the horizon, time to move on :puppykisses:
       
      • Agree Agree x 1
    27. Christian78
      Alone

      Christian78 Member

      Location:
      Gothenburg
      Tinnitus Since:
      (Sep 2013)
      Cause of Tinnitus:
      progressive tinnitus, time of expiring in next 3-6 months
      The only thing i see about Autifony is in USA. We will soon hear if they abolish reserch and that is it...
       
    28. Gill Hayes
      Happy

      Gill Hayes Member Benefactor

      Location:
      North West England
      Tinnitus Since:
      Nov 2014
      Cause of Tinnitus:
      Stress I think
      I think Champ was referring to Scifluor, Auris and Otonomy.
       
    29. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      I don't think they will stop their research. They might fail with the trial in US as well but that doesn't mean that they will shut down their business.
       
      • Agree Agree x 1
    30. AUTHOR
      AUTHOR
      attheedgeofscience
      No Mood

      attheedgeofscience Member Mighty Benefactor Hall of Fame

      Tinnitus Since:
      Childhood
      Cause of Tinnitus:
      Head Injury
      Fast forward a year from now and I doubt that Autifony Therapeutics will still exist. To my knowledge, Autifony Therapeutics does not have in-house research and so any further research will involve collaboration with an outside entity. I therefore do not think that we are likely to see"AUT00063 version 2.0" just around the corner.

      Early stage research is unlikely to be undertaken (= financed) by a small pharma company. And even if Autifony Therapeutics did undertake such research, it would be a while before the fruits of such research could be harvested.

      The above is, of course, just my opinion. Rather than speculating, asking Autifony Therapeutics for a statement would be the correct approach - although any response would probably be limited. I will, however, have to leave the liaison between TT and Autifony Therapeutics to someone else...
       
      • Agree Agree x 2

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