Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

Discussion in 'Research News' started by attheedgeofscience, Sep 19, 2014.

    1. Christian78
      Alone

      Christian78 Member

      Location:
      Gothenburg
      Tinnitus Since:
      (Sep 2013)
      Cause of Tinnitus:
      progressive tinnitus, time of expiring in next 3-6 months
      When I wrote with dr Large he said that aut063 will need some twitching. This was before failure of AUT0063 .


      This was not of interest for me becouse my tinnitus got worse few times in last 2 years (7) and now again last few days i got new tone.
       
    2. Christian78
      Alone

      Christian78 Member

      Location:
      Gothenburg
      Tinnitus Since:
      (Sep 2013)
      Cause of Tinnitus:
      progressive tinnitus, time of expiring in next 3-6 months
      Otonomy:

      We expect this study to be completed in the first half of 2016, with initiation of a Phase 2 study in tinnitus patients to begin in the second half of 2016.
       
      • Like Like x 2
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    3. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      They might not shutdown depending on the development of their other drugs not tinnitus related. As far as I understand, it doesn't look like to me they have something else in mind for tinnitus.
       
    4. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      I'm not saying they won't but I think it's more likely that they will try to expand into other areas. They will trial their drug for schizophrenia for instance. But it is possible that they will abandon their research for hearing disorders or that they perhaps will disappear from the grid for a while to work on something new.
       
    5. amandine

      amandine Member

      Tinnitus Since:
      july 2014
      Who cares until they come up with a drug to help us? What is the point of the conversation?
       
      • Like Like x 1
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    6. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      None at this point really. I would however prefer it if they continued their research inspite of their hick-up with the trial.
       
    7. newarrior

      newarrior Member

      Location:
      Bangkok
      Tinnitus Since:
      12/1996
      Cause of Tinnitus:
      Concerts
      Hi David,


      Apologies for delayed response and Thank you for contacting us regarding your potential participation in the QUIET-1 study for tinnitus. On October 12th 2015 we announced that QUIET-1 was to be discontinued following a planned analysis that was conducted half way through the study { http://autifony.com/autifony-tinnitus-phase-IIa-trial.asp }, which indicated that AUT00063 was safe and well tolerated, but did not show evidence of efficacy on peoples tinnitus. Naturally this is a disappointment for everyone involved with the trial, but it is not unusual in early stage clinical trials of novel drugs.

      Please feel free to contact us for any queries you may have.

      Kind Regards,

      Poonam

      Poonam Chowdhary

      Clinical Trial Associate

      Autifony Therapeutics Limited
       
      • Agree Agree x 1
    8. Champ
      Woot

      Champ Member Benefactor

      Location:
      Boston, MA
      Tinnitus Since:
      01/2013
      Cause of Tinnitus:
      Acoustic trauma from headphones
      Who is this from? This seems like a response to an email?
       
    9. newarrior

      newarrior Member

      Location:
      Bangkok
      Tinnitus Since:
      12/1996
      Cause of Tinnitus:
      Concerts
      This is from the Autifony
       
    10. Nick Pyzik
      Depressed

      Nick Pyzik Member

      Tinnitus Since:
      6/23/15
      Cause of Tinnitus:
      Listening to in-ear headphones & playing in a band
      I don't mean to make this post sound rude to you but I figured I'd let you know that with hearing loss, there is a huge difference between frequencies heard by hair cells and the nerve fibers that actually play a role in how well you hear that certain frequency. It's been researched and found that these nerve fibers have a larger chance of being damaged. Once these nerves are damaged, hyperacusis and tinnitus will start and overtime they will retract back into the brain thus causing the person to have to live with the sound heard 24/7. That's why people who still have normal hearing with their audiograms have tinnitus.
       
      • Agree Agree x 1
    11. AUTHOR
      AUTHOR
      attheedgeofscience
      No Mood

      attheedgeofscience Member Mighty Benefactor Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      Resolved since 2016
      Cause of Tinnitus:
      See information page
      This is the "final nail in the coffin" so-to-speak (in relation to the QUIET-1 study)

       
      • Informative Informative x 5
    12. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      Finding out why something isn't effective could be just as beneficial as finding why it does work.
      Let us hope they will find why it wasn't doing what was expected.
       
      • Agree Agree x 2
    13. Dutchy
      Not worthy

      Dutchy Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      12/2014
      Cause of Tinnitus:
      Neuronmodulation suggests noise induced?
      I guess that explains why i'm not getting a reply from them.(trial)
       
    14. c0ldsun
      Pacman

      c0ldsun Member

      Location:
      Germany
      Tinnitus Since:
      10/2013
      Cause of Tinnitus:
      stress
      Trail for AUT00206 has started: http://autifony.com/autifony-news.asp
      A treatment for schizophrenia. Probably it helps also for tinnitus who knows.

      Edit: i just see it's from end of Nov, but i didnt know this and maybe some other find it interesting too
       
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    15. Poyraz

      Poyraz Member

      Tinnitus Since:
      February 2016
      Cause of Tinnitus:
      Benzos, Stress, Anxiety, Loud Music, Jaw Problems. Who knows
      I want to ask about this study. Will it work for T caused from ETD?
       
    16. AUTHOR
      AUTHOR
      attheedgeofscience
      No Mood

      attheedgeofscience Member Mighty Benefactor Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      Resolved since 2016
      Cause of Tinnitus:
      See information page
      Perhaps toothpaste also helps. Who knows.
       
      • Funny Funny x 1
    17. just1morething
      Benevolent

      just1morething Member Benefactor

      Location:
      U.S.
      Tinnitus Since:
      2008
      Cause of Tinnitus:
      barotrauma, noise exposure, TMJ, neck?
      Maybe AUT00063 would work for erectile dysfunction or hemmoroids as a salvage use??:p
       
      • Funny Funny x 2
    18. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      I wonder how Aut is doing with the Clarity trial? I could use some clearing up with my hearing. Ironically, early today I was just thinking about this drug, and how I read few raving reviews of it during the trial (Corrine being one). I haven't read one raving review of AM101, but it must be doing well since the trial is so advanced. I realize just reading internet posts on how a med works or doesn't really doesn't mean anything, but it just struck me as something odd. Oh well, moving on...
       
    19. AUTHOR
      AUTHOR
      attheedgeofscience
      No Mood

      attheedgeofscience Member Mighty Benefactor Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      Resolved since 2016
      Cause of Tinnitus:
      See information page
      Very true. In fact, one of the axioms of tinnitus pharmacology relates to the fact that tinnitus can be modulated by intravenous Lidocaine injections. The suppressive results are short lived, long term side effects unacceptable, but it is known to work (although no one knows exactly how...).
       
      • Like Like x 1
    20. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      Yes. I really think that we have to focus more on creating a bulletproof way of determining whether someone has tinnitus and the severity of it in an objective way. It has to be an objective way, it can't depend on that persons subjective view. We also need to do the same in animal models. I'm understanding that this is not really done yet and seems to be one of the issues in why Autifony's drug failed. They used aspirin to induce tinnitus in the animals.

      If we do that. If we find a way to be 100% sure that an individual has tinnitus in an objective way. A brain scan or whatever way we can do it. Then we can throw all the drugs known to mankind on it! Every new drug coming out for whatever else we can throw at it and actually see if it does something to tinnitus. We don't have to know how they work or anything. Just test it out and see if it does something or not. But we have to have that objective way of diagnosing tinnitus.

      We can have bio- and organic chemists playing with creation of new compounds and eventually we will come across something that works.

      I may sound like an immoral prick now but I really don't understand why they aren't using primates as test animals. They are less then 1,5% different from us genetically and they can be trained to respond to questions. We can actually ask a chimp if it has tinnitus or not. And if you are really sensitive and won't use chimps. Use another type of monkey that is a bit less intelligent but still a much closer relative to us than a rat!
       
    21. Willice22

      Willice22 Member

      What does being slimy have to do with anything you are talking out of your ass. Of course it is " slimy it is meant to be that way to stop the the product from draining.
       
    22. _Patrick_
      Wishful

      _Patrick_ Member Benefactor

      Location:
      Paris (France)
      Tinnitus Since:
      06/2014
      Cause of Tinnitus:
      Unkown
      It has nothing to do, those are two different sentences, one of them answering a question someone asked me, which was, what do my ENT think about AM101 since he is a very well-known tinnitus specialist and participated in the AM101 study. Slimy in a way that it is too dense and too hard to inject. Those are his words, not mine, but of course, translation is never very accurate as you can see I am French.
      So before you start being rude, maybe you should learn how to read more carefully and use your brain... Trust me, that helps.
       
    23. Mic
      Buzzed

      Mic Member

      Tinnitus Since:
      -
      • Informative Informative x 2
    24. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      I've had numerous correspondences with Dr. Large, and it was very clear he didn't intend to abandon testing and research for T just because 063 didn't show overall efficacy.
       
      • Like Like x 5
    25. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      Glad to hear it!
       
    26. Champ
      Woot

      Champ Member Benefactor

      Location:
      Boston, MA
      Tinnitus Since:
      01/2013
      Cause of Tinnitus:
      Acoustic trauma from headphones
      Everytime they fail the next attempt is that much better :)
       
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      • Optimistic Optimistic x 1
    27. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      Has anyone else seen that a new Aut63 trial is about to begin for those with cochlear implants? I wonder if this means their Clarity trial is showing some positive results? Regardless of how it gets to market, I'd like to try it. Maybe I'd have luck like Mrs.D :)
       
    28. Mario martz
      Creative

      Mario martz Member

      Tinnitus Since:
      02/2016
      Whos Mrs D?
       
    29. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      She's one of the TT member who had success in the Aut trial for her T. There was another as well, I think MPT was the username?
       
    30. Beste
      Disappointed

      Beste Member

      Tinnitus Since:
      02/16/2016
      Cause of Tinnitus:
      Benzo/Clonazepam, Stress
      Isn't MPT the one who got cured hinself with Trobalt?
       

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