Can Blocking HCN2 Ion Channels Silence Tinnitus? RNID Funds Prof. McNaughton's Team to Find Out

Discussion in 'Research News' started by Nick47, Dec 23, 2022.

    1. Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      RNID is funding a project at King’s College London and the University of Nottingham to test if it is possible to lessen or even silence tinnitus, by blocking the activity of an ion channel associated with chronic pain.
      RNID: Chronic pain – how it might help us find a treatment for tinnitus
      Academic profile of Prof. McNaughton
      Publications by Prof. McNaughton
       
      • Informative Informative x 11
      • Like Like x 6
      • Hug Hug x 1
      • Good Question Good Question x 1
    2. KoolKat

      KoolKat Member

      Location:
      USA
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      HeadPhones/ Noise induced
      Very good find bro, I love hearing stuff like this :watching: I just hope it doesn't take a decade for human trials. :sour:

      And wasn't this experiment done before?
       
      • Like Like x 1
      • Agree Agree x 1
    3. AUTHOR
      AUTHOR
      Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      @KoolKat, this research started about 3 years ago. It's in animal stage as far as I'm aware.
       
      • Informative Informative x 3
    4. Cbush

      Cbush Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Age loud noise
      Just wondering, is there anything new on this?
       
      • Good Question Good Question x 2
    5. AUTHOR
      AUTHOR
      Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      "Professor McNaughton’s team, working with experts in tinnitus at the University of Nottingham, will test the effectiveness of different drugs that block HCN2 channels in reducing tinnitus in animals. This work is being supported by one of our Translational Research Grants."​

      Looks like pre-clinical stage. There are a couple of papers published by him this year on pain and migraine but no human studies.
       
      • Like Like x 2
    6. HopeForSilence
      Sad

      HopeForSilence Member Podcast Patron Benefactor

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      Explosion/noise
      I got an answer from Professor McNaughton:

      "Thank you for contacting me. Our work has shown that tinnitus is driven by the HCN2 isoform (protein conformation) – but unfortunately the HCN4 isoform is critical for a normal heart rate. What we need is to develop a drug that can distinguish between these two closely related forms of the protein. Will this be possible? It’s not yet clear, and so a practical drug that can be used in the clinic is some distance away.

      Sorry not to be able to be more optimistic. [...]"​
       
      • Informative Informative x 4
      • Winner Winner x 1
    7. KoolKat

      KoolKat Member

      Location:
      USA
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      HeadPhones/ Noise induced
      So is he confirming HCN2 Isoform is responsible for all this madness?

      Or, because there have been no human clinical trials, this, like all the rest, is just a theory...
       
      • Good Question Good Question x 2
    8. Stayinghopeful
      Procrastinating

      Stayinghopeful Member

      Location:
      NSW, Australia
      Tinnitus Since:
      06/2022
      Cause of Tinnitus:
      COVID-19 / Anesthesia
      Sorry, but can someone explain if this is related to potassium channels and if this all ties into the Dr. Susan Shore's theory?
       
      • Good Question Good Question x 2
    9. AnthonyMcDonald
      Confused

      AnthonyMcDonald Member

      Location:
      Russia
      Tinnitus Since:
      06/2021
      Cause of Tinnitus:
      Noise induced
      There isn't much relation of KCNQ2/KCNQ3 potassium channels to Dr. Shore, other than her briefly going over that information in her papers, and both potential treatments being related to the Dorsal Cochlear Nucleus.
       
      • Agree Agree x 3
    10. Stayinghopeful
      Procrastinating

      Stayinghopeful Member

      Location:
      NSW, Australia
      Tinnitus Since:
      06/2022
      Cause of Tinnitus:
      COVID-19 / Anesthesia
      So basically this is good news as there is now a prominent hypothesis/theory that’s finally agreed upon as a potential treatment if I’m looking at it in a positive light?
       
    11. AnthonyMcDonald
      Confused

      AnthonyMcDonald Member

      Location:
      Russia
      Tinnitus Since:
      06/2021
      Cause of Tinnitus:
      Noise induced
      You can't say that they are exactly the same. The Susan Shore device has a very large impact on stimulating the somatic systems, so to speak (trigeminal nerve, etc), not only the DCN. I can't say they are exactly the same. But certainly Susan's profound success is a positive indicator for this potential potassium channel treatment.
       
      • Like Like x 1
      • Agree Agree x 1
      • Helpful Helpful x 1
    12. dd314

      dd314 Member

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Acoustic Trauma + stress?
      After some research into this, there's already a drug that blocks this particular channel, called Ivabradine. It's used for POTS which I and many other people have after getting COVID-19. There is one single anecdote of it stopping someone's tinnitus:

      "Yes, it definitely has. These are the improvements that I have noticed:

      • NO FAINTING EPISODES!
      • No more tinnitus
      • No more tremors
      • Drastically reduced dizziness and brain fog
      • Reduced fatigue
      • Reduced blurry vision and hearing/visual disturbances
      • Reduced breathlessness and palpitations
      • Reduced nausea
      • Better memory and concentration
      • Dramatically reduced exercise and heat intolerance
      • Less problems with reduced sweating
      • Fewer issues with cold extremities and blood pooling
      • Fewer low moods (I would not say I felt depressed but I did find myself feeling overwhelmed and down at times)
      • Better sleep and fewer nightmares"
      Source: https://liveyourselfbetter.wordpres...-beta-blockers-ivabradine-and-a-happy-ending/
       
      • Informative Informative x 5
    13. AnthonyMcDonald
      Confused

      AnthonyMcDonald Member

      Location:
      Russia
      Tinnitus Since:
      06/2021
      Cause of Tinnitus:
      Noise induced
      While this does show promise, further research needs to be conducted. One thing that makes someone better can make another worse.
       
      • Agree Agree x 1
      • Helpful Helpful x 1
    14. Tomas80

      Tomas80 Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknow. Maybe stress?
      I'm going to try Ivabradine. Off label. Fingers crossed, I'm going to be a guinea pig. I will try anything, I can't describe the suffering. I will keep you updated...
       
      • Like x 6
      • Hug x 5
      • Agree x 1
      • Winner x 1
      • Optimistic x 1
    15. AUTHOR
      AUTHOR
      Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      @Tomas80, sorry. I understand.

      Did you try Latuda?
       
    16. Tomas80

      Tomas80 Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknow. Maybe stress?
      I got Ivabradine first. I'll try itfor a few weeks. I won't try Latuda, but when I finish Ivabradine, I will then try Reagila (Cariprazine).
       
      • Like Like x 1
      • Informative Informative x 1
    17. chinup

      chinup Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Loud music
      I am diagnosed with POTS and have had it for several years, even before COVID-19. I’d absolutely try this medication if there’s a chance it could (safely) reduce my tinnitus. I’ll start researching it.

      To be clear: Ivabradine blocks both HCN2 and HCN4? I’m not a biologist and don’t really understand how these channels work...
       
      • Hug Hug x 1
      • Informative Informative x 1
    18. AUTHOR
      AUTHOR
      Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      @chinup, HCN4 is to do with the heart. I think it slows it down. As you know, as soon as you stand up, you get tachycardia if you have POTS.

      I saw this on Twitter:

      "My tinnitus improved, not necessarily because of, but whilst taking, Ivabradine. My BP is low all the time. I had to stop taking all meds & supplements for a few days recently, & the tinnitus was back full-time, so *something* is making a difference to me."​
       
      • Winner Winner x 1
      • Informative Informative x 1
    19. IndyMLVC

      IndyMLVC Member

      Location:
      NYC
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Unknown
      Does Latuda do it as well? My psych had suggested that.
       
    20. AUTHOR
      AUTHOR
      Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      @IndyMLVC, does Latuda do what? What are you asking?
       
    21. Tomas80

      Tomas80 Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknow. Maybe stress?
      Third day Ivabradine 5 mg daily. I just took my heart rate - 49.

      OMG. I'm normally in the 70s to 90s due to stress and anxiety from the tinnitus. No change in tinnitus yet.
       
      • Informative Informative x 1
    22. IndyMLVC

      IndyMLVC Member

      Location:
      NYC
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Unknown
      I'm asking what does Latuda do? Why was it brought up?
       
    23. AUTHOR
      AUTHOR
      Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      @IndyMLVC, it was brought up by 1 member who had significant success. It has a pharmacological profile that suggests it 'might' work for others too, based on antagonism of 5-HT receptors and dopamine agonists. Read the medication thread.

      It's also relatively new to market.
       
      • Informative Informative x 1
Loading...

Share This Page