Cortical Surface Plasticity Promotes Map Remodeling and Alleviates Tinnitus in Adult Mice

Discussion in 'Research News' started by Nick47, Nov 5, 2023.

    1. Nick47

      Nick47 Member Benefactor Hall of Fame

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      Animal study on electrical activation of the cortex after hearing loss induced tinnitus.
      Cortical Surface Plasticity Promotes Map Remodeling and Alleviates Tinnitus in Adult Mice
       
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    2. Stayinghopeful
      Procrastinating

      Stayinghopeful Member Benefactor

      Location:
      NSW, Australia
      Tinnitus Since:
      06/2022
      Cause of Tinnitus:
      Worsened with COVID-19 / Anesthesia
      God I’m so happy for those mice being cured.
       
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    3. AfroSnowman
      Balanced

      AfroSnowman Member Hall of Fame

      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Nonnatural energy source
      Mice have all the luck.
       
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    4. Joeseph Stope
      Innocent

      Joeseph Stope Member Podcast Patron Benefactor

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      noise? infection? negative stress? other?
      Are you a man or a mouse?
       
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    5. beefling

      beefling Member

      Location:
      Nova Scotia, Canada
      Tinnitus Since:
      10/2021
      Cause of Tinnitus:
      Cumulative noise/Dysacusis
      At this rate we're going to make mice immortal with all the testing we do on them.

      Oh wait...
       
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    6. ZFire
      Pacman

      ZFire Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      2012 (mild) & 04/2021 (severe)
      Cause of Tinnitus:
      Ototoxicity (2012) Unknown-likely noise induce (2021)
      How are they determining whether the mice have tinnitus? If they’re using either behavioral tests or acoustic startle reflex to define the presence of tinnitus, then this study doesn’t do much for me I’m afraid.
       
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    7. eagerUser

      eagerUser Member Benefactor

      Location:
      Berlin, Germany
      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise
      It doesn't do much for you? Maybe because you are not a mouse?
       
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    8. Travis Henry
      Cynical

      Travis Henry Member Hall of Fame

      Location:
      Dallas,TX
      Tinnitus Since:
      10/2021
      Cause of Tinnitus:
      1 Moderna Vac, Noise and stress I guess, its killing me
      If only I was a mouse! Fudge.
       
    9. AUTHOR
      AUTHOR
      Nick47

      Nick47 Member Benefactor Hall of Fame

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      • Informative Informative x 1
    10. Travis Henry
      Cynical

      Travis Henry Member Hall of Fame

      Location:
      Dallas,TX
      Tinnitus Since:
      10/2021
      Cause of Tinnitus:
      1 Moderna Vac, Noise and stress I guess, its killing me
      Where do we go to get this done? I'll hold 'em up to do it.
       
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    11. JimmyStrong
      Depressed

      JimmyStrong Member

      Tinnitus Since:
      12/2022
      Cause of Tinnitus:
      Noise induced/Hearing loss related
      How long do you think it will take until they try this on a human?
       
      • Good Question Good Question x 1
    12. AUTHOR
      AUTHOR
      Nick47

      Nick47 Member Benefactor Hall of Fame

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      To me this is electrical stimulation of the auditory cortex. It's already been done non-invasively in humans.
       
    13. ZFire
      Pacman

      ZFire Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      2012 (mild) & 04/2021 (severe)
      Cause of Tinnitus:
      Ototoxicity (2012) Unknown-likely noise induce (2021)
      2.7. Conditioned active-avoidance task as a behavioral measure of tinnitus
      As expected.

      C9D66965-0A42-4396-8D53-4E2C8C194937.gif

      I can’t wait till the day arrives when we can objectively diagnose and detect tinnitus (with great reliability) in both human and animals without having to resort to subjective and unreliable self-reports and behavioral tests to assess tinnitus and potential solutions. Because right now, there is no outcome measure that is reliably applicable to both human and animal studies in a way that gives us consistent results, nor is there a way to establish a consistent benchmark for comparison between the two.
      There’s no reason to automatically assume that it will undoubtedly work on humans.
       
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