http://blog.arthritis.org/living-with-arthritis/anti-inflammatory-tumeric-curcumin/
How Curcumin Works
Curcumin seems to target specific molecules or pathways that control the cell cycle. It also blocks inflammatory cytokines and enzymes, including 5-LOX and cyclooxygenase-2 (COX-2), the target of the drug celecoxib. That's why studies have shown that it can be helpful for people with osteoarthritis. For example, a 2016 review of eight randomized controlled trials found that 1000 mg a day of curcumin relieved OA pain as effectively as nonsteroidal anti-inflammatories (NSAIDs) like ibuprofen – minus the intestinal side effects. Other research suggests that low doses of curcumin may help restore a normal balance between T cells that cause inflammation (Th17 cells) and those that protect against it (regulatory T cells). The imbalance in these cells is believed to drive lupus and other autoimmune diseases. And a small study published in Molecular Medicine in 2016 suggests that curcumin may help to prevent bone erosion in people with rheumatoid arthritis.
How Curcumin Works
Curcumin seems to target specific molecules or pathways that control the cell cycle. It also blocks inflammatory cytokines and enzymes, including 5-LOX and cyclooxygenase-2 (COX-2), the target of the drug celecoxib. That's why studies have shown that it can be helpful for people with osteoarthritis. For example, a 2016 review of eight randomized controlled trials found that 1000 mg a day of curcumin relieved OA pain as effectively as nonsteroidal anti-inflammatories (NSAIDs) like ibuprofen – minus the intestinal side effects. Other research suggests that low doses of curcumin may help restore a normal balance between T cells that cause inflammation (Th17 cells) and those that protect against it (regulatory T cells). The imbalance in these cells is believed to drive lupus and other autoimmune diseases. And a small study published in Molecular Medicine in 2016 suggests that curcumin may help to prevent bone erosion in people with rheumatoid arthritis.
