Deaf People Get Gene Tweak to Restore Natural Hearing

Discussion in 'Research News' started by Garden Ring, Apr 24, 2014.

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    1. Garden Ring
      Mellow

      Garden Ring Member

      Location:
      Moscow
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Loud concert
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    2. LeQuack
      Scared

      LeQuack Member Benefactor

      Location:
      United States of Europe
      Tinnitus Since:
      2005
      Cause of Tinnitus:
      Bad luck and bad genes
    3. Hudson
      Cowboy

      Hudson Member Benefactor

      Tinnitus Since:
      2003
      It will be very interesting to see how this pans out. KU's Otolaryngology clinic is a pretty cutting edge place it seems. They have been taking part in a lot of trials, including AM-101. I always liked that area of Kansas City, as it is pretty close to the Power and Light District... which is not a great place for us tinnitus sufferers but it was a damn fun time anyway! :)
       
    4. Champ
      Woot

      Champ Member Benefactor Team Tech

      Location:
      Boston, MA
      Tinnitus Since:
      1/2013
      Cause of Tinnitus:
      Acoustic trauma from headphones
      Seriously, this is a long time coming... like any part of our body our ears should have a chance to regen.
       
    5. James White
      Anime

      James White Member Benefactor

      Location:
      Toulouse, France
      Tinnitus Since:
      April 2013
      Cause of Tinnitus:
      Maybe loud music. Not sure.
      Well this looks very interesting ! Let's hope everything goes as planned
       
    6. Grace
      No Mood

      Grace Member

      Tinnitus Since:
      11/14/2013
      Good start in the right direction
       
    7. Champ
      Woot

      Champ Member Benefactor Team Tech

      Location:
      Boston, MA
      Tinnitus Since:
      1/2013
      Cause of Tinnitus:
      Acoustic trauma from headphones
      No way I want something unexpected and crazy to happen like they get superhearing or some shit.
       
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    8. Garden Ring
      Mellow

      Garden Ring Member

      Location:
      Moscow
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Loud concert
      I already 'hear' more than I'm supposed to, so I'd just prefer my normal hearing back, thanks!
      :)
       
      • Agree Agree x 2
    9. dan
      Chatty

      dan Member

      Tinnitus Since:
      06/2011
      Staecker estimates that the approach could help 1 to 2 per cent of all people with hearing loss...

      Why so little?
       
    10. t-man
      Suicidal

      t-man Member

      Tinnitus Since:
      2009
      Deaf people? I hope this treatment is done to people with noise induced hearing loss because we know that their they suffer from damaged hair cells. Deafness is so broad.

      I'm confident that they must be targeting people who suffer from actual noise trauma because blindness often doesn't start at the eye but rather the brain, much like deafness.

      That's what I was thinking. This is kind of the golden ticket, here.
       
    11. rtwombly
      Bookworm

      rtwombly Member

      Location:
      Southeast USA
      Tinnitus Since:
      01/2014
      Cause of Tinnitus:
      Unknown
      There are fears that the regenerated hair cells may not react like natural hair cells, which could compromise good hearing. That's why they are starting with the profoundly deaf. There's also mention that they prefer people who went deaf due to ototoxicity, which I would guess is significant only because of the way they induced deafness in the lab animals. Seems kinda rough for the patients, though. They may get some weird noises that are nothing like the hearing they remember.
       
    12. t-man
      Suicidal

      t-man Member

      Tinnitus Since:
      2009
      As long as it's not constant ringing some sound is probably better than no sound.
       
    13. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
      Hi,
      this experiment is mainly a proof of concept.
      Genvec, the biotec company behind this trial will get some milestone payments from pharma multi
      Novartis if they can reach their goals, hair cell regeneration and an improvement of 10dB. (the press says 20dB)
      It's an important trial. If it works, I am sure they will invest more to optimize the outcome and therapy.
      They look for severe hearing impaired people, because they aren't sure what will happen
      if new hair cell grow and mix up with the residual hair cells. So there are many uncertain things,
      all most everything.
      I hope there won't be any harm to the patients due to the novel kind of therapy.
      I also hope there won't any problems which would shed a bad light on
      gene-therapy in general.

      But if the results would result positive, this field of research would be shifted very much.


      Greets Tom
       
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    14. Grace
      No Mood

      Grace Member

      Tinnitus Since:
      11/14/2013
      If this is successful and 10 % ( 20%) whichever is achieved do you think they will then go for more percentage such as 50 % hearing back? Or is this drug they have not capable or they would
      Have to come up with another to do that.
       
    15. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
      Hi Grace,

      this is all uncertain. It's also uncertain, if regeneration will take effect on all frequencies. Probably it's just high, or low frequency. It's also uncertain, if there is increase by repeating... maybe the scientists know more.
      If it works in principle, I am sure they have to tewak many many parameters until they get
      a causal and effective treatment torwards regain a relatively normal, natural hearing.
      Probably, they can one day repair hearing in some selective way.

      It's exciting!

      Greets Tom
       
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    16. bill 112
      Studious

      bill 112 Member

      Location:
      Republic Of Ireland
      Tinnitus Since:
      02/2012
      Cause of Tinnitus:
      Noise exposure
      IN 2 MONTHS TIME!!!!Thats amazing that they are starting so soon I was expecting to be like 40 when they even began testing this method.We always say in the future they will be able to cure this and that but what we dont realise is that the future has arrived.Amazing stuff lets just hope it works....without the U.S.A or the U.K its preety fair to say the world would be a shittier place.
       
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    17. Kimbo Slice
      Balanced

      Kimbo Slice Member

      Location:
      Canada
      This is very exciting news indeed. This treatment is actually geared towards people who have NIHL, SSHL, or Ototoxicity. It's stated that they are testing on people who are profoundly deaf, and will not be able to test on people who were born deaf as they may not have the structures in the ear to support the growth unfortunately. Just to clear things up a little.
       
    18. Grace
      No Mood

      Grace Member

      Tinnitus Since:
      11/14/2013
      Gottcha!!! Well its one step at a time then :)
       
    19. latestnight
      Crappy

      latestnight Member

      Tinnitus Since:
      ~2010
      Exciting stuff. I can't wait to hear the results!
       
    20. yonkapin

      yonkapin Member Benefactor

      Location:
      Melbourne, Australia
      Tinnitus Since:
      March 2012
      Holy sh*t, this is a pretty huge step forward! Can't wait to see how things pan out from here.
       
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    21. James White
      Anime

      James White Member Benefactor

      Location:
      Toulouse, France
      Tinnitus Since:
      April 2013
      Cause of Tinnitus:
      Maybe loud music. Not sure.
      • Agree Agree x 1
    22. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
      Hi,
      yes it's correctly that this experiment hasn't to do either with restoring hearing to normal nor erasing tinnitus.
      But if they can get the most out of this research, results might improve. And probably if we can correct hearing loss one day, there might be a reduction of Tinnitus too... at least, we really don't know...
      This is basic work, proof of principle and highly experimental.

      Greets Tom
       
    23. NikoD
      English

      NikoD Member

      Tinnitus Since:
      11/2012
      Deafness is broad. This news is exciting and I have every hope something positive comes out of it and other work like it by other researchers and Scientists.
       
    24. bill 112
      Studious

      bill 112 Member

      Location:
      Republic Of Ireland
      Tinnitus Since:
      02/2012
      Cause of Tinnitus:
      Noise exposure
      Was just thinking do you remember when you were younger and someone mentioned the word scientist and you were like pfffsshh NERDS!!Now when someone mentions scientists it takes a whole new meaning.Its research and work like this that makes them so invaluable in todays world.Just hope everything goes to plan....
       
    25. MattK

      MattK Member

      Tinnitus Since:
      2/13/2014
      I know, I kept hearing that they were planning on curing hearing loss in 10 years... so I figured that this was at least a few years away before we got to this point. I am blown away that they are already at human trials. And if it is successful, then like most things, they will continue to perfect the technique and research and it will just continue to improve.
       
    26. Champ
      Woot

      Champ Member Benefactor Team Tech

      Location:
      Boston, MA
      Tinnitus Since:
      1/2013
      Cause of Tinnitus:
      Acoustic trauma from headphones
      I mean, step 1 is to regenerate the ear if it's structurally in place, like it is for all of us. It's amazing we're doing this now, and I expect the techniques to mature rapidly (they are maturing rapidly because of pressure on the medical community to produce results)

      Step 2 is to regenerate a new cochlea entirely for people with severe head trauma/damage and implant it back in. That's gonna be fucking crazy too!
       
    27. Rog

      Rog Member

      Location:
      NY and Brazil
      Tinnitus Since:
      02/2014
      Nothing for Tinnitus???
       
    28. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
      Yes, just hope, step 1 doesn't harm people in trial, this would be a major backdraw.
      If there would be just a little enhancement would be a big advance.
      In general, it's very interesting to see how researchers could trigger hair cell regeneration in some
      very different ways. For such a complex process, it's surprising they have different approaches.
      https://hearinglosscure.stanford.edu/research/

      Stem Cell Replacement would be the best, but it's also the most complex of the very complex
      approaches.
       
      • Like Like x 1
    29. MattK

      MattK Member

      Tinnitus Since:
      2/13/2014
      The prevailing theory is that tinnitus is the result of hearing loss in most cases; i.e. hearing loss is the underlying cause for tinnitus. So if the underlying cause is fixed, then tinnitus will be cured. So that's why we're excited.
       
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    30. Kimbo Slice
      Balanced

      Kimbo Slice Member

      Location:
      Canada

      To back this claim up. There was a study done, showing that pretty much everyone has some form of Tinnitus, if put into a completely soundproof room. Something like 200 people were put into a soundproof room and were told to press a button if they heard a sound. 96% of these people pressed the button lol. Now think about it. If anyone loses hearing at any frequency and can hear tinnitus in a completely silent room, than it's most likely that hearing loss will make that sound more audible/ noticeable.
       

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