Decibel Therapeutics Partnership with Regeneron

Discussion in 'Research News' started by Aaron123, Nov 29, 2017.

    1. Aaron123

      Aaron123 Member

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    2. acufenero
      Starving

      acufenero Member

      Tinnitus Since:
      August 2014
      Cause of Tinnitus:
      Acoustic trauma
      Huge news!
       
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    3. Benoves

      Benoves Member

      Tinnitus Since:
      26-9-2017
      Cause of Tinnitus:
      Unknow possibly noise trauma
      Great! This is what we want to see.
       
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    4. Makrohn
      Wishful

      Makrohn Member Benefactor Advocate

      Location:
      Norway
      Tinnitus Since:
      1996
      Cause of Tinnitus:
      Hearing loss - Explosion -Stress
      Wonderful news, this is exactly what we need them to do!
       
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    5. parsky

      parsky Member

      Tinnitus Since:
      8/1/17
      Cause of Tinnitus:
      Unknown
      Great news. I want to see something in a phase I here soon. They have been working for a number of years, but nothing appears to be ready for trails.
       
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    6. Paulmanlike

      Paulmanlike Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      I came across this before and was about to post it, but noooooo Aaron decided to post it first
       
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    7. Paulmanlike

      Paulmanlike Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Do you know what Decibal talks about developing therapeutics for hearing loss AND tinnitus, and while I read and try my best to comprehend the science behind repairing hearing loss I don't read anything that suggests how they are addressing tinnitus. It seems they are hoping that repair or regeneration of hair cells is just going to decrease or eliminate tinnitus which would be great, but what I'm saying there isn't anything that I've read from them on how they are planning on treating tinnitus or the MoA on how it will work.

      I'm also curious how Decibal could help me if their advancements ever come to the market, I have normal hearing on a normal audiogram and when I've tried testing myself above 8 kHz everything seems normal. No hypercausis but just tinnitus in one ear, that is loud and piercing and would like very much to get rid of it.
       
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    8. Samir
      Obedient

      Samir Manager Staff Benefactor Ambassador Advocate

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      Keep your eyes open for the next one then! ;)
       
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    9. Paulmanlike

      Paulmanlike Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Take @Aaron123 for example, he is dark and mysterious, we know nothing about him as a community, but his knowledge wow his knowledge, he is straight to the facts and he is on the ball with the research. You know when he posts I make myself a cup of tea because you know it's going to be interesting and a good read.
       
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    10. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      And this partnership could put pressure up for other companies.
       
    11. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      This is great news. I wish we could learn more about what they are up to though. Ever since these companies have gone private I don't see any articles about any breakthroughs on research anymore.
       
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    12. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
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    13. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
       
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    14. Turner
      Balanced

      Turner Member

      Location:
      East Coast/USA
      Tinnitus Since:
      01/16/2018
      Cause of Tinnitus:
      Acoustic Trauma
      Let's hope they move fast!
       
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    15. MickV

      MickV Member

      Tinnitus Since:
      11/2017
      Cause of Tinnitus:
      Rock concert
      Lol...yeah...see you in 10 years! That’s how science and berucracy moves. Slow pase
       
    16. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      Is there any information as to what they discussed? or how they propose to accelerate a cure?
       
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    17. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
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    18. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Bronx N.Y.C
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      acoustical trauma
      upload_2018-8-3_17-52-20.png
       
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    19. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      “This raises critical questions...”

      What does this mean? They make it sound like something positive, but I read it like something negative :)
       
    20. JohnAdams
      Sweet tooth

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Ousside
      Tinnitus Since:
      Iyyar, 5778
      Cause of Tinnitus:
      noise/nsaids
      If they can restore hearing at lost frequencies I would bet my bottom dollar that the associated tinnitus frequencies will be absent the errant tinnitus sounds because youll be actuallu hearing those frequencies again. If the T is still present at those frequencies after hearing is restored then how could you actually be hearing again?
       
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    21. dan26
      Frustrated

      dan26 Member

      Location:
      NJ
      Tinnitus Since:
      1981
      Cause of Tinnitus:
      complete loss of hearing. motorcycle accident
      how i wish i can hear normally again!!! Deafness and tinnitus sucks big time even with a cochlear implant on one side!
       
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    22. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
      As far as I understand, Decibel Therapeutics does not have a ready-made substance with which they are going to perform regeneration, in contrast to Frequency.

      They are only in search of / developments of this substance. So?

      Financing the company is quite good - they received the first round of investment capital of $55 million. Among the investors is also the company Google Ventures.

      In fact, these investors have funded dozens of projects in the field of biotechnology.

      But I would like to believe that Decibel Therapeutics will make a real result.

      Why Space Matters to Decibel Therapeutics
       
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    23. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      The video you just posted above is exactly why I gave up on Decibel early on. They are spending gobs of dollar focused on developing a space for their employees happiness rather then doing tests, experiments, and developing precinal products. I dont buy the whole concept that expensive customly designed space will result in innovation. Just frustrating to see the gross mis-allocation of resources.
       
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    24. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
      Yes, too much attention to corporate culture, and not to the real effectiveness of the company's research.
      A huge spacious office with many employees who sit behind expensive computers.

      They have a good investment, even better than Frequency Therapeutics, but so far there are no visible results.

      I hope investors will require them to be more efficient and quick, otherwise they will not pay back their investments for a long time.
       
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    25. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Santa Barbara, CA
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      Interesting concept. So if I sit in the lobby of a super high-end hotel for a week, maybe I can come up with a world-changing idea too!!
       
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    26. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Santa Barbara, CA
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      I live in a one bedroom apartment. No wonder all my ideas suck. :(
       
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    27. Johan_L

      Johan_L Member

      Location:
      Sweden
      Tinnitus Since:
      05/2015
      Cause of Tinnitus:
      Noise induced
      With nice offices they can more easily attract and retain the best talent.

      With that said, I hope they come up with a cure ASAP...
       
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    28. Manny
      Dead

      Manny Member Benefactor Hall of Fame

      Location:
      United States
      Tinnitus Since:
      1/2018
      Cause of Tinnitus:
      NIHL due to acute acoustic trauma
      I don't know, that one was pretty good;)
       
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    29. JohnAdams
      Sweet tooth

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Ousside
      Tinnitus Since:
      Iyyar, 5778
      Cause of Tinnitus:
      noise/nsaids
      Yeah wtf is up with that? That is beyond superficial and pointless. "Dur we're trying to cure debilitating diseases, look how fancy our office space is." Hopefully this is just some goofy crap from their PR department and doesnt reflect the overall company culture and mission.
       
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    30. Manny
      Dead

      Manny Member Benefactor Hall of Fame

      Location:
      United States
      Tinnitus Since:
      1/2018
      Cause of Tinnitus:
      NIHL due to acute acoustic trauma
      I don't know, I think it's a smart move. The way I see it, FX Therapeutics is sort of a get-rich-quick scheme compared to Decibel. Their funding is smaller and you can see that they outsourced their current trials to the small Alamo ENT.
      This is not to say that FX doesn't have an excellent idea or that it won't work (I hope and pray that it does!)
      But Decibel seems to be in it for the long haul. The ear is really, really complicated. If you want to really figure things out, you need to start from the ground up, and a top-notch research space is important. Unfortunately there is still so much about the auditory system that science doesn't know. That's the way I see it.
      Personally I'm glad that both types of companies exist. The more the better!!
       
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