Evaluation of Vinpocetine as a Therapy in Patients with Sensorineural Hearing Loss

Discussion in 'Research News' started by vttbx, May 17, 2021.

    1. vttbx

      vttbx Member Benefactor

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      Evaluation of vinpocetine as a therapy in patients with sensorineural hearing loss: A phase II, open-label, single-center study

      Abstract
      The progressive degeneration of the excitable cells of the ear depends on the sustained excitation of the voltage-sensitive sodium channels, so the negative pharmacological modulation could be a rational therapeutic strategy against the damage of these cells.

      The objective was to demonstrate the effectiveness of Vinpocetine (VPC), a potent sodium channel blocker, as a treatment for acquired sensorineural hearing loss.

      A phase II, longitudinal and prospective open clinical study, was conducted over a period of 12 months with patients older than 18 years, to demonstrate the effectiveness of Vinpocetine (VPC) as a treatment for acquired sensorineural hearing loss, using evoked potentials, otoacoustic emissions, audiometry and logoaudiometry, analyzing the results at 6 and 12 months of treatment with Vinpocetine (30 mg/day in 3 doses).

      It was observed that from 0 to 6 months there was hearing impairment (which was already expected due to the age of the patients). From 6 to 12 months and from 0 to 12 months there were significant differences with a tendency towards improvement, indicating that the aforementioned deterioration not only stopped, but that with the use of vinpocetine, the hearing capacity improved.

      It is concluded that Vinpocetine helps to stop hearing impairment and even improve hearing.
       
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    2. Mentos

      Mentos Member Benefactor

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      Vinpocetine has been available on the market for many years already. Why did they even bother to do another trial?
       
    3. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
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      Sshl
      Where do you get it?
       
    4. Lukee

      Lukee Member Podcast Patron Benefactor Ambassador

      Location:
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      Any health food store. At least in Canada.
       
    5. Ecip

      Ecip Member

      Location:
      Edmonton, AB/Switzerland
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      4.11.2015
      Cause of Tinnitus:
      Still unknown... possibly noise exposure?
      Various online herbal/supplement shops carry it, as well as local shops.
       
    6. Stanlex
      Wtf

      Stanlex Member

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      It is so weird that on American continent you can get almost every substance in supplement form in health food store while in Europe you can get the same substance only as Rx drug from your doctor.
       
    7. Stanlex
      Wtf

      Stanlex Member

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      I guess it helps only people who have age-related hearing loss, just like Ginkgo Biloba helps with tinnitus seniors only.
       
    8. Stanlex
      Wtf

      Stanlex Member

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      That's true but much is not known about Vinpocetine and it is also used mainly for cerebral deficiency in old people. They give it to seniors after a stroke, for dementia, for tinnitus (works similarly like Ginkgo biloba), but somebody just wanted to know if it works on hearing loss as well.

      It's quite common to test old drugs if they work on something they weren't used for. For example Dexamethasone for COVID-19.
       
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    9. Lukee

      Lukee Member Podcast Patron Benefactor Ambassador

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      Not entirely true. There’s a lot of OTC drugs in Europe that we need to get Rx for. That being said, Europe has a lot of countries and prescription laws vary greatly from country to country. Some places basically everything is OTC lol.
       
    10. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
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      June 2020
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      NIHL
      The Vinpocetine supplements sold in those health stores often has little to no Vinpocetine. The clinical trial is using pharma grade stuff, which is the real deal.

      Like many supplements on the market, what you can buy today is just placebo.
       
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    11. ajc

      ajc Member

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    12. Mentos

      Mentos Member Benefactor

      Location:
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      In Europe Vinpocetine is available in drug stores but you need prescription, i.e. in Poland the drug is called Cavinton.

      It’s prescribed for tinnitus but usually with little to no effect.
       
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    13. Lukee

      Lukee Member Podcast Patron Benefactor Ambassador

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      So do we just double down on it? Lol.
       
    14. GBB

      GBB Member Hall of Fame

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    15. Kriszti

      Kriszti Member Benefactor

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      Here in Hungary, Vinpocetine, Pentoxifylline and Piracetam (mainly Piracetam in IV and/or per os) are quite routinely prescribed for tinnitus. They are all Rx drugs.

      Let's just say that the results are not satisfying, although some benefit from them.
       
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    16. Karl28
      No Mood

      Karl28 Member

      Location:
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      2001 bad since 2015
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      Pretty sure I took Vinpocetine once and it made my tinnitus spike badly.
       
    17. AUTHOR
      AUTHOR
      vttbx

      vttbx Member Benefactor

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      Do they recommend stacking all three?
       
    18. Kriszti

      Kriszti Member Benefactor

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      I'm a bit lost in translation. You mean do they recommend to take all three types of medication at the same time?
       
    19. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

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    20. AUTHOR
      AUTHOR
      vttbx

      vttbx Member Benefactor

      Location:
      Los Angeles
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      Yes. Stacking is a common term meaning taking multiple supplements at the same time. FYI, I never met a stack I didn't like. :)
       
    21. Kriszti

      Kriszti Member Benefactor

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      Well, in that case, no. :)

      I think Piracetam is most commonly used. After onset lots of people get it in IV form with/without steroids for around 5-10 days, then in tablets. I did not get IV but took Nootropil 2x1200 mg per os (along with Betahistine) for 2 and 2.5 months. It did nothing.

      Vinpocetine (Cavinton) is also used in IV and in tablets as well. I don't know about Pentoxifylline (Trental).

      Doctors' opinions widely differ, some say none of them does anything, some say they are worth a try, and some say that it is not exactly for healing but for preventing a worsening and protecting hearing :dunno:

      They are not prescribed together and patients are advised to only take them till midday because they might rev your brain up and sleep could be an issue.

      Based on the probably biased experience in my local tinnitus group, they barely do anything and if yes, mostly for elder people, but there are exceptions.
       
    22. AUTHOR
      AUTHOR
      vttbx

      vttbx Member Benefactor

      Location:
      Los Angeles
      Tinnitus Since:
      01/2001
      Cause of Tinnitus:
      Noise Induced
      What are your thoughts on this study?
       
    23. VeryUnfortunate
      Stressed

      VeryUnfortunate Member Benefactor

      Tinnitus Since:
      January 2021
      Cause of Tinnitus:
      Acoustic Trauma
      Has anyone else on Tinnitus Talk tried Vinpocetine?
       
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