Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. briano
      Wishful

      briano Member

      Tinnitus Since:
      09/2013
      Are REGAIN and Frequency Therapeutics the two companies leading the way to cure hearing loss or are there others to keep an eye on also?
       
      • Good Question Good Question x 2
    2. Ken219
      Frustrated

      Ken219 Member

      Location:
      New York Area
      Tinnitus Since:
      Summer of 1990
      Cause of Tinnitus:
      Noise exposure?
      Glad they may cure hearing loss. I'll keep my hearing loss, just cure my tinnitus :)
       
    3. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      There are also some others as well such as Decibel Therapeutics and Otonomy but I think REGAIN and Frequency Therapeutics are further ahead in terms of their phases.

      REGAIN would finish Phase 2 by the end of the year and publish results in January 2020. Not too sure if Frequency have started Phase 2
       
      • Informative Informative x 2
    4. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Otonomy.
       
      • Informative Informative x 2
    5. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      This, like everything else, is moving too slowly.
       
      • Agree Agree x 8
    6. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      Better slow than nothing.... And I really hope for a breakthrough! I want to be able to hear!
       
      • Agree Agree x 5
    7. briano
      Wishful

      briano Member

      Tinnitus Since:
      09/2013
      Having REGAIN, Frequency Therapeutics and Otonomy all working on cures are a lot more options than we had just a few years ago. I personally did the LLLT for 2 years. Although it calmed down my tinnitus, it never helped me regain my hearing loss. I'm keeping my eye on these 3.
       
      • Agree Agree x 1
    8. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      Me too. Being able to hear music again would be the most joyful moment in my life.
       
      • Agree Agree x 4
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    9. urgentresearch
      Probing

      urgentresearch Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Unknown (possibly withdrawal-induced)
      Phase 2 has not started yet but when it does they will announce it.
       
      • Like Like x 1
    10. urgentresearch
      Probing

      urgentresearch Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Unknown (possibly withdrawal-induced)
      Fun fact: there are 43 companies currently working on hearing restoration drugs right now :)
       
      • Optimistic Optimistic x 5
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    11. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      I just would think that considering how many vets there are with tinnitus/hearing loss that the ATA would be working with the government to pour a lot of money into this instead of treating it like any other pharma company making any other drug. Considering that the ATA's head, LaGuinn Sherlock, was a research audiologist with the U.S. Army Public Health Center you'd think something like that would be happening.
       
      • Agree Agree x 7
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    12. Bobbette

      Bobbette Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Unknown
      I apologize for going off tangent here for a moment!
      You'd think wrong. LaGuinn Sherlock believes everyone will habituate and there's no need for drug treatments. She's a disgrace in my book!

      https://www.tinnitustalk.com/thread...-is-this-the-right-message-to-send-out.32191/
       
      • Agree Agree x 4
      • Funny Funny x 1
    13. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      43 companies?? Please list them.
       
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      • Agree Agree x 2
    14. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      If we do get rid of our tinnitus by having our hair cells regenerated, would our ears still be sensitive to certain sounds e.g., blenders, vacuuming, travelling on planes etc.?
       
      • Good Question Good Question x 2
    15. Aleksa Uzunovic

      Aleksa Uzunovic Member

      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Noise induced hearing loss
      My opinion is that, in terms of practical treatment we should mostly keep our eyes on Regain. They are moving much faster than Frequency. They will be done with phase 2 by the end of the year, that's a massive progress. So our best bet to having a cure in a year or two is Regain. Forget Frequency, they're a toast if Regain proves to have have a functioning cure in the Phase 2.
       
      • Agree Agree x 2
      • Good Question Good Question x 1
    16. Ken219
      Frustrated

      Ken219 Member

      Location:
      New York Area
      Tinnitus Since:
      Summer of 1990
      Cause of Tinnitus:
      Noise exposure?
      It would be good to have hearing restored but my prayers go to them finding a tinnitus cure.
       
      • Agree Agree x 4
    17. Ken219
      Frustrated

      Ken219 Member

      Location:
      New York Area
      Tinnitus Since:
      Summer of 1990
      Cause of Tinnitus:
      Noise exposure?
      I see what you mean. Sounds like a wasted position and money. Our goal is to habituate! We pray for researchers to find a cure!

      'Dr. Sherlock works at Walter Reed National Military Medical Center for the US Army Hearing Program as a research audiologist. Her current research interests include the effects of tinnitus on concentration, the efficacy of tinnitus treatment programs, and the evaluation and management of hyperacusis.'
       
    18. parsky

      parsky Member

      Tinnitus Since:
      8/1/17
      Cause of Tinnitus:
      Unknown
      You are assuming both will provide equal results. The literature suggests FX3-22 “cocktail” of small molecules will produce better results than REGAIN’s sole use of just a gamma secretase inhibitor.

      How this translates in vivo for humans we don’t know yet, but I think your conclusion that FX-322 is toast is a bit presumptuous, at this point in time, if they don’t reach the finish line first.
       
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    19. urgentresearch
      Probing

      urgentresearch Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Unknown (possibly withdrawal-induced)
      I don't have them in list format at the moment but when I get a chance I will do some organizing and post them here.
       
      • Like Like x 5
    20. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      Well, I think that we have to wait and see... I am optimistic about both of them, but especially so about FX-322. Don't ask why, but it sounds bit better... ;-) but hey, the more research we have, the better it is, or? BTW: Cocktails are nice ;-)
       
    21. Aleksa Uzunovic

      Aleksa Uzunovic Member

      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Noise induced hearing loss
      I don't care, no matter what kind of improvement, everyone will throw their money at REGAIN if they release their treatment first, even if it doesn't recover hearing fully but only partially. Those lame asses at Frequency Therapeutics will make $0 if they keep with this pace of progress.
       
      • Agree Agree x 5
    22. Hayls32

      Hayls32 Member

      Location:
      London
      Tinnitus Since:
      1997
      Cause of Tinnitus:
      Pulsatle to begin with. Noise exposure later in life
      • Like Like x 1
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    23. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      • Optimistic Optimistic x 2
      • Hug Hug x 1
    24. briano
      Wishful

      briano Member

      Tinnitus Since:
      09/2013
      I'm hoping that we get to hear from the people involved in the trials. I'd like for them to explain in their own words what the results were and how the drugs made them feel.
       
      • Agree Agree x 3
    25. Bobbette

      Bobbette Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Unknown
      They have all had to sign NDAs (non-disclosure agreements).
       
      • Like Like x 1
    26. Jab4

      Jab4 Member

      Tinnitus Since:
      7/31/17
      Cause of Tinnitus:
      Unknown
      You can't keep that a secret, people talk.
       
      • Agree Agree x 3
    27. spedgas
      Depressed

      spedgas Member Benefactor

      Tinnitus Since:
      09/2018
      Cause of Tinnitus:
      Unknown
      They’ve done a pretty good job so far. As these trials get bigger that has to get harder though.
       
      • Agree Agree x 5
    28. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      How does fast tracking work? After they are done with Phase 2 and if it's successful, how fast - after Phase 3 is done - can they release the drug to the market?
       
      • Good Question Good Question x 2
    29. JoNo78

      JoNo78 Member

      Location:
      Kiel, Germany
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Sudden Hearing Loss
      Well, as far as I have understood, Frequency Therapeutics had only patients with massive hearing loss in their trial, whereas REGAIN tested their drug in people with mild to moderate hearing loss. That's a difference of the research/treatment... Or do I interpret it wrong?
       
      • Agree Agree x 3
    30. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      Someone posted this on Reddit:

      I worked on this clinical trial!! This makes me so happy to see the excitement. I don’t really know how much I can say as far as results/patient testimony, but it was the best study I have ever worked on. So rewarding and a great great company!

      What is the likelihood that they will mention that this drug actually reduced or cured their tinnitus at the September event?
       
      • Optimistic Optimistic x 3
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      • Agree Agree x 1

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