Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Aleksa Uzunovic

      Aleksa Uzunovic Member

      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Noise induced hearing loss
      Wait... So there was supposed to be phase 1b and they skipped it???
       
      • Good Question Good Question x 1
    2. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      If there was no Phase 1b, and it went to Phase 2a, then it could be possible to skip Phase 2b and go to Phase 3.
       
      • Agree Agree x 1
      • Optimistic Optimistic x 1
    3. pinklights98
      No Mood

      pinklights98 Member

      Tinnitus Since:
      08/2016
      Cause of Tinnitus:
      Loud Noise Exposure
      Realistically, if this passes all phases of the trial, when can we expect this to be available commercially? I'm really struggling with tinnitus and it would be nice if it could be available sooner than later(as in not ten years from now..)
       
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    4. papu
      Chatty

      papu Member Benefactor

      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Acoustic Trauma
      No one can truly say. It all depends on how well it goes in next the trial. This time they will also be checking how it works for tinnitus. If the results are mind bending and very successful i am positive that we will be seeing something in less than 3 years with fast tracking. If the results are not conclusive or only yields slight improvement, it will be a long road or not be made available at all. That's just an estimated guess.
       
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    5. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      If all goes well, it definitely will be here before 10 years. Maybe even 2-3.

      These guys aren't playing any games.
       
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    6. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      This is true... they are some of the best minds in this field on planet earth.

      We are at the beginning of the regenerative medicine revolution. There will be hiccups, plateaus, failures and successes.

      As desperate as we are, and I am desperate, we need to be “cautiously optimistic” as member d’wooluf said. That way we’re not heartbroken and can work at living in the present. This is not aimed at CBM, but some words of chill for myself and some other comrades who are freaking out.

      Stay cool comrades, one phase at a time, fingers crossed...
       
      • Agree Agree x 3
    7. RingingBrother

      RingingBrother Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise induced hearing loss
      I think the FDA was giving Frequency Therapeutics some extra help even before fast track kicked in. It seems a cure for hearing loss is becoming a top priority because of the effect on the military and the economic loss caused by it is making it a national security issue which is why the DoD started funding hearing restoration research in 2017.
       
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    8. RingingBrother

      RingingBrother Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise induced hearing loss
      If it continues having no safety issues and passes efficacy maybe the FDA and the U.S Military will want it out by 2021.
       
      • Like Like x 2
      • Optimistic Optimistic x 2
      • Agree Agree x 1
    9. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Interesting thought but if they really were preferentially picking test subjects with sudden noise related hearing loss maybe it would be because of something like this...
       
    10. F-u-T

      F-u-T Member

      Location:
      AZ USA
      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Acoustic Trama
      I know exactly when my tinnitus started from NIHL. One really loud music event was all it took. I only have a minor dip in higher frequency range but still within normal for my age group. I had an audiogram prior to acoustic trauma to compare to which showed the slight dip. Probably not enough for the trial requirements though.
       
    11. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      I see a lot of people still thinking that they, figuratively speaking, will find this drug under their Christmas tree next year. People, this is not going to happen. They have to go through Phase 2a, then Phase 2b, then Phase 3. If we’re unlucky they might even have to do a Phase 3b. Each of those phases takes about a year, and usually there are about 4-6 months between each phase. Do the math.

      Now, if we had a situation on our hands where the Phase 1/2 results were stellar, this positive thinking might have had some merit. But they weren’t.

      This “maybe it’s out in 18 months” is really just a - completely understandable - coping mechanism.
       
      • Agree Agree x 2
    12. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      What are you babbling about? No one is saying 18 months.
       
      • Agree Agree x 1
    13. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      Phase 3 might not be required however.
       
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      • Informative Informative x 1
    14. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      It might not, but there’s an equal possibility it has to go through a Phase 3b. We just don’t know. It all depends on how well the drug performs in this phase 2a trial. We should have a lot more information when top-line results are released this time next year. And even then, it’s possible drug performance fluctuates in future trials.
       
      • Agree Agree x 2
      • Informative Informative x 1
    15. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      The drug probably did reach the apex in trace amounts but since this stuff is dose dependent it didn't trigger proliferation.
       
      • Agree Agree x 2
    16. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      Would each person have a different size Apex as well. So some people might need more than others?
       
    17. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Well you'd be wrong because I am exactly that case. I can pinpoint it to the day and I was still turned down.
       
    18. Deathtotinni

      Deathtotinni Member

      Location:
      Parkville Maryland
      Tinnitus Since:
      9/10/17
      Cause of Tinnitus:
      Qtip and maybe a sound..who knows
      I have enough hearing loss I think. I had enough hearing loss for the last trial.
       
      • Informative Informative x 1
    19. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      Hope so! Trouble is I can't help but feel that the exposure decay will be exponential within the cochlea - a bit like dropping a blob of paint and examining the volume that remains inside a given radius of the impact. Given such a decay it could need a LOT of drug to have any impact.
       
      • Agree Agree x 1
    20. mrbrightside614

      mrbrightside614 Member

      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      unknown; acoustic trauma/hyperacusis/sshl
      Just read something that really scared me about the efficacy of stem cells, even when administered IT.

      Even if FX-322 bypasses the need to infuse stem cells with growth factors for appropriate cell differentiation... “in past experiments, transplantation of stem cells into the damaged areas has produced only varying results, and a challenging problem that prevents successful stem cell transplantation is to avoid stem cell deaths. Stem cells often die due to failure to bypass the glial scar, a hallmark of neural damage that is thought to act as a barrier for cell transplantation.”

      This has been addressed by a research team in Kyoto, who “discovered that applying new stem cells to the surface of the glial scar rather than underneath it helps their survival. They reported that the survived stem cells were able to grow from the damaged segment of the auditory nerve, which then travel from the cochlea to the brainstem, the part of the brain which controls flow of messages between the brain and the rest of the body – in this case, the ear - and eventually restored remarkable auditory function.”

      Is the idea that the slow release gel will somehow “soak” into all of the damaged areas in question, including the glial scar? Any way we could get Frequency Therapeutics on the Tinnitus Talk Podcast? Do we have any contact information besides their LinkedIn?
       
    21. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      It's probably close.
       
      • Informative Informative x 1
    22. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I don't think the glial scar is an issue because the drug causes supporting cells to divide where they are.
       
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    23. mrbrightside614

      mrbrightside614 Member

      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      unknown; acoustic trauma/hyperacusis/sshl
      I guess I’m unclear as to the mechanisms here. I saw the visual model prior, but wouldn’t lack of support cells post-differentiation also be cause for concern?
       
    24. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Not sure what you mean.
       
    25. mrbrightside614

      mrbrightside614 Member

      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      unknown; acoustic trauma/hyperacusis/sshl
      Does the division of the support cell into the hair cell deplete the original cell or does it simply divide and remain intact?
       
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    26. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      The division happens first. There is no depletion of supporting cells with FX-322. This seems to differ from REGAIN.
       
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    27. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      With FX-322 it is supposed to divide the supporting cells and then make a hair cell so it maintains supporting cell numbers.
       
      • Like Like x 2
    28. mrbrightside614

      mrbrightside614 Member

      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      unknown; acoustic trauma/hyperacusis/sshl
      Lovely news. We’re looking at 18 months minimum? I can stick it out til then. Swear if they don’t end up serving tinnitus patients I’m blowing this ear out.
       
      • Like Like x 2
    29. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Keep in mind we don't actually know if it helps with tinnitus yet.

      Best bets are probably on neuromodulation devices and maybe the pills so far.
       
    30. mrbrightside614

      mrbrightside614 Member

      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      unknown; acoustic trauma/hyperacusis/sshl
      What makes you partial to the pill over FX-322? Systemic circulation seems like a reach to me. Would imagine there would be significantly greater potential for side effects and bioavailability issues.
       

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