Gene-Correction Therapy Improves Hearing Loss by 10 !imes

Discussion in 'Research News' started by Gb3, Apr 21, 2022.

    1. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
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      Sshl
      A Severance Hospital research team has confirmed that gene-editing therapy can treat progressive hearing loss.

      As a result, after seven weeks, AAV-injected mice showed an average hearing improvement of 20 dB in the entire frequency range (6-30 kHz).

      Gene-correction therapy improves hearing loss by 10 times
       
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    2. blamingeverything

      blamingeverything Member Benefactor

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      high frequency hearing loss
      Put it in me.
       
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    3. Street Novelist
      Depressed

      Street Novelist Member

      Location:
      Bay Area
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      February 2018
      Cause of Tinnitus:
      Listening to loud music through headphones
      It says age-related heay loss. Would it also work for sudden hearing loss due to loud noise?
       
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    4. Geatly

      Geatly Member

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      Noise induced, by jackhammering into concrete on constructio
      Most age-related hearing loss is due to noise, it's just not as fast as when you experience acoustic shock.
       
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    5. Padraigh Griffin

      Padraigh Griffin Member Podcast Patron Benefactor

      Tinnitus Since:
      05/2020
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      Is Korea the place to live for hearing loss and tinnitus sufferers?

      Interesting it is potassium channel related again.

      More 'science' pointing towards potassium channel malfunction.
       
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    6. ColinUK

      ColinUK Member

      Tinnitus Since:
      2013 initial, worsened 2020
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      Why do they keep using mice... Seems that everything works well on mice but that's not translating to positive human results. I think these researchers need to pick a different test animal. Give the mice a break :ROFL: :D
       
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    7. Joey72
      Approved

      Joey72 Member

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      Yeah, like monkeys.
       
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    8. ThomasF
      Creative

      ThomasF Member

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      Florida
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      I'm going to build a time machine and have humans evolve from rodents instead of apes. All these treatments are helping those suckers out. This is great news regardless.
       
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    9. Geatly

      Geatly Member

      Tinnitus Since:
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      Cause of Tinnitus:
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      They can try it on me.
       
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    10. blamingeverything

      blamingeverything Member Benefactor

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      high frequency hearing loss
      As you might imagine, there are many good reasons they use mice. It's not like they set out to fail.
       
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    11. Geatly

      Geatly Member

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
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      Another reason rodents are used as models in medical testing is that their genetic, biological and behavioral characteristics closely resemble those of humans, and many symptoms of human conditions can be replicated in mice and rats.

      "Rats and mice are mammals that share many processes with humans and are appropriate for use to answer many research questions," said Jenny Haliski, a representative for the National Institutes of Health (NIH) Office of Laboratory Animal Welfare.
       
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    12. ThomasF
      Creative

      ThomasF Member

      Location:
      Florida
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Probably loud music
      I remember reading somewhere that most lab mice are inbred to maintain a constant genetic baseline. I don't know if that applies much to this study but can't help but be paranoid in thinking that maybe this lineage of mice has some mega ears that just want to regenerate on their own.
       
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    13. Geatly

      Geatly Member

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      Noise induced, by jackhammering into concrete on constructio
      That would happen then in all of them, not just dosed.
       
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    14. ThomasF
      Creative

      ThomasF Member

      Location:
      Florida
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Probably loud music
      Could we not clone a human cochlea and then apply this gene therapy to see if it works? Or is a fully living system necessary to test these things out?
       
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    15. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      Look up cochlear organoids. It's being used to test these kinds of things.
       
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    16. Philip83
      Jaded

      Philip83 Member Podcast Patron Benefactor

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      "The team also confirmed that the gene-editing also improved the damaged outer hair cells in the mice whose hearing improved."

      :woot:
       
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    17. Street Novelist
      Depressed

      Street Novelist Member

      Location:
      Bay Area
      Tinnitus Since:
      February 2018
      Cause of Tinnitus:
      Listening to loud music through headphones
      I wonder how long we'll have to wait for this therapy; years, a decade?
       
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    18. Champ
      Woot

      Champ Member Benefactor

      Location:
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      This news is awesome but I need to know their timeline to getting this to human trials.
       
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    19. Geatly

      Geatly Member

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      Noise induced, by jackhammering into concrete on constructio
      As fast as possible please, this hearing damage is just the worst thing I have experienced in my life, and I got some serious problems.
       
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    20. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor Hall of Fame

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      From mice to first human safety study? 2-4 years I'd think. All of these solutions are pretty far away.
       
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    21. Jerad

      Jerad Member

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      Ohio; United States
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      If you build that time machine, that’s the real cure. :D We won’t need any treatments, just different decisions to alter our lives. How’s the progress coming?
       
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    22. ThomasF
      Creative

      ThomasF Member

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      I want there to be a way to expedite human application without risking safety. Reality is most of the obstacles can be overcome with boatloads of money.
       
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    23. ThomasF
      Creative

      ThomasF Member

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      I started out small and tried converting a microwave oven. Cranked the magnetron into a high enough frequency that it messed with the light bulb inside. Then tried to see what would happen to an apple. It melted and burned. The smell was both acrid and sweet like burning caramel.
       
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    24. ThomasF
      Creative

      ThomasF Member

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      FWD: Sorry for triple post.

      My scientific literacy may be failing me here but I can't help but notice that the article associated with this describes a situation that more than likely will help those with Potassium channel issues as opposed to those whose hearing loss and tinnitus are the product of acoustic traumas. Which is to say those with genetically sourced hearing loss are going to benefit spectacularly. The treatment uses CRISPR which tailored the DNA of the subject mice to mend a genetic flaw. Hence the term "gene correction". Granted CRISPR and gene manipulation has potential for hearing loss caused by noise exposure itself.
       
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    25. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

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      I remain skeptical: gene-editing seems to me like the Pandora Box (cancer triggering...)
       
    26. Geatly

      Geatly Member

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
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      I will risk it. If the body doesn't understand that it needs to build up back those structures, then it doesn't deserve to live.
       
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    27. ThomasF
      Creative

      ThomasF Member

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    28. Hottopic29

      Hottopic29 Member Benefactor

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      I'll take it.
       
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    29. ThomasF
      Creative

      ThomasF Member

      Location:
      Florida
      Tinnitus Since:
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      Cause of Tinnitus:
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      Keep your fingers crossed it can work on humans.
       
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    30. Hottopic29

      Hottopic29 Member Benefactor

      Location:
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      I'll take it over the cancer risk if it has one.
       
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