GW-201 aka Tetrandrine (TET) by Gateway Biotechnology (NEOMED's Jianxin Bao)

This drug aims to treat tinnitus. Known by its codename GW-201, it is apparently a substance called Tetrandrine (TET).

Jianxin Bao's Gateway Biotechnology Inc recently received a grant for $972,613 from the National Institute on Deafness and Other Communication Disorders (NIDCD) which he said allows his team to work toward finding the first drug treatment for tinnitus. He is a researcher and professor of anatomy and neurobiology at Northeast Ohio Medical University (NEOMED), but also has his own company, the aforementioned Gateway Biotechnology, which has several products in the pipeline for preventing and treating noise-induced hearing loss, tinnitus, and Cisplatin ototoxicity:



But let's focus on GW-201.

We're in good hands because, according to this blog post, Dr. Bao often reads Tinnitus Talk:

This was the initial media coverage on him getting the almost a million-dollar grant to treat tinnitus:
NEOMED researcher receives federal grant for first human tinnitus treatment

On the U.S. Department of Health & Human Services you can find the following details on the grant:

Award Number: R44DC018759
Targeting multiple signaling pathways for tinnitus prevention and treatment

Clicking "View Award Abstract" shows more details about GW-201 aka Tetrandrine (TET):

It's interesting to note that should Tetrandrine fail at clinical stage, their strategy of optimizing second-generation products built upon Tetrandine and its chemical analogs gives them the opportunity to identify additional drug candidates that might help treat tinnitus.

What else do we know about Tetrandine?
Wikipedia says that it has anti-inflammatory, immunologic and antiallergenic effects. It's isolated from the plant Stephania tetrandra and other Chinese and Japanese herbs. It can reduce blood pressure. It's even showed therapeutic efficacy against Ebola in preliminary studies.

When you search PubMed for Tetrandine, you get 968 results, none of which mention tinnitus.

There is, however, the following paper by Dr. Bao, which is about Tetrandrine having otoprotective effects:
Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma

When can we expect more developments?
@reggie green reached out to Gateway Biotechnology in February 2020, who then responded:

@HootOwl also reached out to them in February, and got the following response:

It's great news that only half a year later from the above correspondence they've been able to raise the additional funding.

 

Wow! Thank you for sharing all this information, @SallyM.

 

Keep hope alive, it sounds very promising. We have to hang in there.

 

Stuff will come out. It is not going to be too far from being a reality either.

 

Hell yeah. Technology advances quickly these days. This is leading to huge improvements in health/medicine as well. Gotta keep the faith alive.

 

The research really has advanced due to the fact that there have been big advancements in the technology. This is the big big driver as all of a sudden we are able to see stuff we have never seen before with computer modelling, devices like microscopes and other lab technology like manufacturing stuff. This will be the big boon of the treatment field in this decade.

Just look at the reasons why they have been able to advance the coronavirus drug --- because the virus can be decoded better.

 

The drug in question is meant to be herb (as above) derived, isn't it?

I read an abstract about the study using a herb called Stephania tetrandra that is already available in China.

Has anyone thought to try this herb?

Does anyone have any further info about how faulty calcium signalling could cause tinnitus?

 

Isn’t this drug in clinical trials for COVID-19 caused pneumonia already?

 

This is true.

https://clinicaltrials.gov/ct2/show/NCT04308317

Feeling like this, and the Hough pill as well, are dead ends, but can't know until its tried.

 

Anti-inflammatory makes me believe it belongs to the same category as AM-101/Keyzilen, meaning it's geared towards treating tinnitus at the earliest stage (the so called acute phase).

 

I would agree it's probably treating acute. That's what most people are trying to treat, because it's what the army wants.

 

Actually, I take that back. It's working on Calcium ion channels as well, so maybe it can help.

 

Calcium ion channels are also involved in the accrue phase. If I remember correctly release of calcium is one of the steps in the cascade of things leading to hair cell death after loud noise exposure.

 

You can buy Stephania tetrandra (fang ji) online:
https://www.activeherb.com/extract/fangji.shtml

 

Are you going to try it?

 

Umm... now I see that vale of sample groups, control groups and placebo tests.

 

According to Wiki:

The root contains many isoquinoline alkaloids: tetrandrine (0.6-0.9%), fangchinoline (0.5%), cyclanoline (0.1%) and dimethyltetrandrine iodide (muscle relaxant). The root also contains flavanoids. The main active alkaloids are: tetrandrine (12 to 23 grams/kg) and fangchinoline (0.3–3 mg/kg).​

Looks like the herb only contains very small amount of tetrandrine, so not sure if it will be potent enough. Regardless, my local Chinese herbal store has it so I might give it a go...

 

Any updates?

 

The herb is reported to be poisonous if consumed in large amounts.

 

Only took it for about a couple of weeks and didn't see any benefits.

 

→ Identifying Molecular Pathways Underlying Noise-Induced Tinnitus

Small thesis/animal study using Tetrandrine. Positive results.