GW-201 aka Tetrandrine (TET) by Gateway Biotechnology (NEOMED's Jianxin Bao)

Discussion in 'Research News' started by SallyM, Jul 21, 2020.

    1. SallyM

      SallyM Member Podcast Patron Benefactor

      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Unknown
      This drug aims to treat tinnitus. Known by its codename GW-201, it is apparently a substance called Tetrandrine (TET).

      Jianxin Bao's Gateway Biotechnology Inc recently received a grant for $972,613 from the National Institute on Deafness and Other Communication Disorders (NIDCD) which he said allows his team to work toward finding the first drug treatment for tinnitus. He is a researcher and professor of anatomy and neurobiology at Northeast Ohio Medical University (NEOMED), but also has his own company, the aforementioned Gateway Biotechnology, which has several products in the pipeline for preventing and treating noise-induced hearing loss, tinnitus, and Cisplatin ototoxicity:

      gateway-biotechnology-gw-201-tetrandine-tinnitus.png

      But let's focus on GW-201.

      We're in good hands because, according to this blog post, Dr. Bao often reads Tinnitus Talk:

      This was the initial media coverage on him getting the almost a million-dollar grant to treat tinnitus:
      NEOMED researcher receives federal grant for first human tinnitus treatment

      On the U.S. Department of Health & Human Services you can find the following details on the grant:

      Award Number: R44DC018759
      Targeting multiple signaling pathways for tinnitus prevention and treatment

      Clicking "View Award Abstract" shows more details about GW-201 aka Tetrandrine (TET):
      It's interesting to note that should Tetrandrine fail at clinical stage, their strategy of optimizing second-generation products built upon Tetrandine and its chemical analogs gives them the opportunity to identify additional drug candidates that might help treat tinnitus.

      What else do we know about Tetrandine?
      Wikipedia says that it has anti-inflammatory, immunologic and antiallergenic effects. It's isolated from the plant Stephania tetrandra and other Chinese and Japanese herbs. It can reduce blood pressure. It's even showed therapeutic efficacy against Ebola in preliminary studies.

      When you search PubMed for Tetrandine, you get 968 results, none of which mention tinnitus.

      There is, however, the following paper by Dr. Bao, which is about Tetrandrine having otoprotective effects:
      Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma

      When can we expect more developments?
      @reggie green reached out to Gateway Biotechnology in February 2020, who then responded:
      @HootOwl also reached out to them in February, and got the following response:
      It's great news that only half a year later from the above correspondence they've been able to raise the additional funding.
       
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    2. urgentresearch
      Probing

      urgentresearch Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Unknown (possibly withdrawal-induced)
      Wow! Thank you for sharing all this information, @SallyM.

      :puppykisses:
      :thankyousign:
       
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    3. reggie green
      Balanced

      reggie green Member

      Tinnitus Since:
      03/08/2001
      Keep hope alive, it sounds very promising. We have to hang in there.
       
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    4. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Stuff will come out. It is not going to be too far from being a reality either.
       
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    5. asey20
      Curious

      asey20 Member Benefactor

      Location:
      Toronto
      Tinnitus Since:
      July 13, 2020
      Cause of Tinnitus:
      Not sure.
      Hell yeah. Technology advances quickly these days. This is leading to huge improvements in health/medicine as well. Gotta keep the faith alive.
       
      • Agree Agree x 2
    6. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      The research really has advanced due to the fact that there have been big advancements in the technology. This is the big big driver as all of a sudden we are able to see stuff we have never seen before with computer modelling, devices like microscopes and other lab technology like manufacturing stuff. This will be the big boon of the treatment field in this decade.

      Just look at the reasons why they have been able to advance the coronavirus drug --- because the virus can be decoded better.
       
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    7. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      The drug in question is meant to be herb (as above) derived, isn't it?

      I read an abstract about the study using a herb called Stephania tetrandra that is already available in China.

      Has anyone thought to try this herb?

      Does anyone have any further info about how faulty calcium signalling could cause tinnitus?
       
    8. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      Isn’t this drug in clinical trials for COVID-19 caused pneumonia already?
       
    9. asey20
      Curious

      asey20 Member Benefactor

      Location:
      Toronto
      Tinnitus Since:
      July 13, 2020
      Cause of Tinnitus:
      Not sure.
      This is true.

      https://clinicaltrials.gov/ct2/show/NCT04308317

      Feeling like this, and the Hough pill as well, are dead ends, but can't know until its tried. :dunno:
       
    10. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      Anti-inflammatory makes me believe it belongs to the same category as AM-101/Keyzilen, meaning it's geared towards treating tinnitus at the earliest stage (the so called acute phase).
       
    11. WillBeNimble
      Buzzed

      WillBeNimble Member Podcast Patron Benefactor

      Location:
      Ohio
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Acoustic Damage from earphones
      I would agree it's probably treating acute. That's what most people are trying to treat, because it's what the army wants.
       
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    12. WillBeNimble
      Buzzed

      WillBeNimble Member Podcast Patron Benefactor

      Location:
      Ohio
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Acoustic Damage from earphones
      Actually, I take that back. It's working on Calcium ion channels as well, so maybe it can help.
       
    13. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      Calcium ion channels are also involved in the accrue phase. If I remember correctly release of calcium is one of the steps in the cascade of things leading to hair cell death after loud noise exposure.
       

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