Hough Ear Institute's Hair Cell Regeneration Project

[Caveman]

Funding has prevented us from doing it ourselves. The Phase II study is approximately 7 million dollars. We are in negotiations with a couple of different biotech firm rights now to take the pill and even the injection technology forward.

I hope to be able to share some great and exciting news in the next month or two!

What about performing a Phase II study in the European Union? Are you willing to conduct clinical trials in Europe, too?

 

[Auron]

@Justin De Moss Do yous guys know how supporting cells are affected.For example, someone who used this pilled suffered a second acoustic trauma,will they be able to use it a second time.How about ribbon synapse's,do they also use supporting cells.Since,from my understanding, this pill address both issue's.

Thanks in Advanced!

 

[Auron]

@Justin De Moss I have another question.Hopefully I can word my thought's correctly.

Many, if not all other approaches to restore hearing,seem to use intratympanic injection,if I'm correct,you guys are also developing one to tackle hearing loss in addition to the pill approach.These therapies biggest obstacles seem to be delivery of the drug.From my limited knowledge,other approaches such as oral ingestion resulted in very serious side effects in animal studies,hence intratympaic injection being the popular method for drug delivery for hearing restoration.I previously thought that a pill solution was impossible before hearing about HEI,but here we are.My question is,how does the body know how to deliver the medicine to the appropriate area without affecting all other cells/tissue on it's way to the auditory system?Seems to me,that there would be ample opportunity for the drug to end up in the wrong spot.

Thanks again in advanced!

 

[Sevv]

If we get this through phase 2 with funding, would there be sufficient funding for phase 3? If yes, then it shouldn't be too difficult to crowd-fund the seven millions. I mean that's 1 dollar from maybe 1 in every 10 people who have hearing problems just in the US.

 

[ChrisBoyMonkey]

@Justin De Moss,

Have you guys reached out to the DoD for funding? If this pill really is that promising, the funding for more research is not much at all compared to what goes to VA tinnitus claims.

 

[Rb86]

Have you guys reached out to the DoD for funding? If this pill really is that promising, the funding for more research is not much at all compared to what goes to VA tinnitus claims.

Hough Ear Institute has already received funding from the DoD in the past.

 

[ChrisBoyMonkey]

Hough Ear Institute has already received funding from the DoD in the past.

Good! Time for more!

 

[vttbx]

@Justin De Moss,

Have you guys reached out to the DoD for funding? If this pill really is that promising, the funding for more research is not much at all compared to what goes to VA tinnitus claims.

The D-Methionine study had DoD funding but they terminated the study in Phase 3 when the funding ran out. I had high hopes for this treatment and was following it for years. I hope Hough has better luck.

https://clinicaltrials.gov/ct2/show/NCT02903355

 

[ChrisBoyMonkey]

The D-Methionine study had DoD funding but they terminated the study in Phase 3 when the funding ran out. I had high hopes for this treatment and was following it for years. I hope Hough has better luck.

https://clinicaltrials.gov/ct2/show/NCT02903355

Same here. They're saying they are already seeing it helps with tinnitus, so it is something the VA should vigorously pursue.

 

[FGG]

Looks like this is Hough's biotech pharmaceutical partner:

Otologic pharmaceuticals
http://otologicpharma.com/pipeline/

I'm really encouraged by the fact that their drug not only causes supporting cells to differentiate into hair cells but also the supporting cells themselves to proliferate (as long as orgs safe and phase 1 says it is).

 

[JohnAdams]

Same here. They're saying they are already seeing it helps with tinnitus, so it is something the VA should vigorously pursue.

Vigorously fund as well.

 

[Caveman]

Same here. They're saying they are already seeing it helps with tinnitus, so it is something the VA should vigorously pursue.

I know it sounds naive, but what keeps us from buying L-Methionine over the counter and just see if it works?

 

[JohnAdams]

The D-Methionine study had DoD funding but they terminated the study in Phase 3 when the funding ran out. I had high hopes for this treatment and was following it for years. I hope Hough has better luck.

https://clinicaltrials.gov/ct2/show/NCT02903355

Wait, what!? It's like someone out there wants us to have tinnitus.

 

[Daniel Lion]

Looks like this is Hough's biotech pharmaceutical partner:

Otologic pharmaceuticals
http://otologicpharma.com/pipeline/

I'm really encouraged by the fact that their drug not only causes supporting cells to differentiate into hair cells but also the supporting cells themselves to proliferate (as long as orgs safe and phase 1 says it is).

I wish I could share your optimism... I don't know why I remain so dubious... Perhaps it's because they are a non-profit, and I've seen no publications, although in theory they exist...

What's wrong with me? Why am I being so ambivalent about these guys?

 

[MRItechssuck]

• Phonak. Owned by Swiss-based company Sonova and founded in 1947.
• Oticon. Owned by William Demant and based in Denmark, Oticon is often credited with trailblazing many hearing aid firsts and setting standards for innovation.
• Signia (formerly Siemens).
• ReSound (GN Group).
• Starkey.
• Widex.

"Global hearing aid market to reach USD 12.1 billion by 2025."

 

[JohnAdams]

A drug to treat tinnitus made it into phase 3 and lost funding....... Hot damn, let that sink in.

 

[all to gain]

A drug to treat tinnitus made it into phase 3 and lost funding....... Hot damn, let that sink in.

Why did it lose funding? Did the drug have any results?

Man, I've given up to be honest.

 

[GoatSheep]

A drug to treat tinnitus made it into phase 3 and lost funding....... Hot damn, let that sink in.

Yeah when I read that my heart sank. All this research tracked, discussed and debated on here may never see the light of day in the end. After years of putting hopes for relief into it.

 

[FGG]

Correction: looks like this has been covered in another thread but apparently only the pill has been tested through phase 1. This is the antioxidant for noise trauma (acute?).

The regeneration injection (OPI-001) I don't believe has gone through phase 1.

 

[Jurger]

I wish I could share your optimism... I don't know why I remain so dubious... Perhaps it's because they are a non-profit, and I've seen no publications, although in theory they exist...

What's wrong with me? Why am I being so ambivalent about these guys?

Hough research has been published in prestigious journals repeatedly. Just search for articles (co-)authored by Dr. Kopke.

 

[Caveman]

Yeah when I read that my heart sank. All this research tracked, discussed and debated on here may never see the light of day in the end. After years of putting hopes for relief into it.

Instead of vainly debating, we'd better try out a bottle of L-Methionine and see what happens to our ears... it's a safe drug, after all!

 

[all to gain]

Correction: looks like this has been covered in another thread but apparently only the pill has been tested through phase 1. This is the antioxidant for noise trauma (acute?).

The regeneration injection (OPI-001) I don't believe has gone through phase 1.

So we are still 10+ years off anything that treats tinnitus?

 

[lcj]

Instead of vainly debating, we'd better try out a bottle of L-Methionine and see what happens to our ears... it's a safe drug, after all!

What is the difference between D and L methionine?

From what I'm reading it looks like the D form is converted into the L form?

https://www.novusint.com/Portals/0/...rces_Full Article.pdf?timestamp=1443715076894

DL-methionine can be purchased for pets which has both.

@vttbx

 

[FGG]

What is the difference between D and L methionine?

From what I'm reading it looks like the D form is converted into the L form?

https://www.novusint.com/Portals/0/Documents/Methionine/Comparison of Methionine Sources_Full Article.pdf?timestamp=1443715076894

DL-methionine can be purchased for pets which has both.

@vttbx

Correct, used as a urinary acidifier to help prevent (certain types of) recurrent urinary stones.

I wonder if phase 3 was discontinued because it is widely available (through veterinary prescription anyway) and therefore funding without hope of recouping profit would be hard to get.

I would like to read the phase 2 results.

 

[FGG]

This makes it seem like it was for very acute cases only. Anyone else have a source for using it for the longer term sufferers?

https://www.audiology.org/news/clinical-trials-d-methionine-interview-kathleen-campbell-phd

 

[JohnAdams]

This makes it seem like it was for very acute cases only. Anyone else have a source for using it for the longer term sufferers?

https://www.audiology.org/news/clinical-trials-d-methionine-interview-kathleen-campbell-phd

De Moss said it was for both acute and chronic.

 

[OnceUponaTime]

A drug to treat tinnitus made it into phase 3 and lost funding....... Hot damn, let that sink in.

Ugh...one of the many reasons I do not follow any particular treatment. I'll wait for Markku to blast it on the front page when we get one. sigh.

 

[FGG]

De Moss said it was for both acute and chronic.

Sorry, this was about D-methionine

 

[ChrisBoyMonkey]

I know it sounds naive, but what keeps us from buying L-Methionine over the counter and just see if it works?

I think there are different forms of it, not sure if this one is over the counter.

 

[Caveman]

I think there are different forms of it, not sure if this one is over the counter.

The DL-form is over the counter.