Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. Caveman

      Caveman Member

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      2015
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      What about performing a Phase II study in the European Union? Are you willing to conduct clinical trials in Europe, too?
       
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    2. Auron
      Dead

      Auron Member

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      @Justin De Moss Do yous guys know how supporting cells are affected.For example, someone who used this pilled suffered a second acoustic trauma,will they be able to use it a second time.How about ribbon synapse's,do they also use supporting cells.Since,from my understanding, this pill address both issue's.

      Thanks in Advanced!
       
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    3. Auron
      Dead

      Auron Member

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      @Justin De Moss I have another question.Hopefully I can word my thought's correctly.

      Many, if not all other approaches to restore hearing,seem to use intratympanic injection,if I'm correct,you guys are also developing one to tackle hearing loss in addition to the pill approach.These therapies biggest obstacles seem to be delivery of the drug.From my limited knowledge,other approaches such as oral ingestion resulted in very serious side effects in animal studies,hence intratympaic injection being the popular method for drug delivery for hearing restoration.I previously thought that a pill solution was impossible before hearing about HEI,but here we are.My question is,how does the body know how to deliver the medicine to the appropriate area without affecting all other cells/tissue on it's way to the auditory system?Seems to me,that there would be ample opportunity for the drug to end up in the wrong spot.

      Thanks again in advanced!
       
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    4. Sevv

      Sevv Member Benefactor

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      If we get this through phase 2 with funding, would there be sufficient funding for phase 3? If yes, then it shouldn't be too difficult to crowd-fund the seven millions. I mean that's 1 dollar from maybe 1 in every 10 people who have hearing problems just in the US.
       
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    5. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

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      @Justin De Moss,

      Have you guys reached out to the DoD for funding? If this pill really is that promising, the funding for more research is not much at all compared to what goes to VA tinnitus claims.
       
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    6. Rb86

      Rb86 Member

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      Hough Ear Institute has already received funding from the DoD in the past.
       
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    7. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

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      Good! Time for more!
       
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    8. vttbx

      vttbx Member Benefactor

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      The D-Methionine study had DoD funding but they terminated the study in Phase 3 when the funding ran out. I had high hopes for this treatment and was following it for years. I hope Hough has better luck.

      https://clinicaltrials.gov/ct2/show/NCT02903355
       
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    9. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

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      Same here. They're saying they are already seeing it helps with tinnitus, so it is something the VA should vigorously pursue.
       
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    10. FGG

      FGG Member Podcast Patron Benefactor

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      01/2019
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      Looks like this is Hough's biotech pharmaceutical partner:

      Otologic pharmaceuticals
      http://otologicpharma.com/pipeline/

      I'm really encouraged by the fact that their drug not only causes supporting cells to differentiate into hair cells but also the supporting cells themselves to proliferate (as long as orgs safe and phase 1 says it is).
       
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    11. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

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      Vigorously fund as well.
       
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    12. Caveman

      Caveman Member

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      2015
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      I know it sounds naive, but what keeps us from buying L-Methionine over the counter and just see if it works?
       
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    13. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

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      Wait, what!? It's like someone out there wants us to have tinnitus.
       
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    14. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

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      I wish I could share your optimism... I don’t know why I remain so dubious... Perhaps it’s because they are a non-profit, and I’ve seen no publications, although in theory they exist...

      What’s wrong with me? Why am I being so ambivalent about these guys?
       
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    15. MRItechssuck
      Disappointed

      MRItechssuck Member

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      • Phonak. Owned by Swiss-based company Sonova and founded in 1947.
      • Oticon. Owned by William Demant and based in Denmark, Oticon is often credited with trailblazing many hearing aid firsts and setting standards for innovation.
      • Signia (formerly Siemens).
      • ReSound (GN Group).
      • Starkey.
      • Widex.
      “Global hearing aid market to reach USD 12.1 billion by 2025.”
       
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    16. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

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      A drug to treat tinnitus made it into phase 3 and lost funding....... Hot damn, let that sink in.
       
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    17. AUTHOR
      AUTHOR
      all to gain
      No Mood

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      never trust a doctor
      Why did it lose funding? Did the drug have any results?

      Man, I've given up to be honest.
       
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    18. Selah1281

      Selah1281 Member Benefactor

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      Yeah when I read that my heart sank. All this research tracked, discussed and debated on here may never see the light of day in the end. After years of putting hopes for relief into it.
       
    19. FGG

      FGG Member Podcast Patron Benefactor

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      Correction: looks like this has been covered in another thread but apparently only the pill has been tested through phase 1. This is the antioxidant for noise trauma (acute?).

      The regeneration injection (OPI-001) I don't believe has gone through phase 1.
       
    20. Jurger

      Jurger Member

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      2004
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      Hearing loss
      Hough research has been published in prestigious journals repeatedly. Just search for articles (co-)authored by Dr. Kopke.
       
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    21. Caveman

      Caveman Member

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      Instead of vainly debating, we'd better try out a bottle of L-Methionine and see what happens to our ears... it's a safe drug, after all!
       
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    22. AUTHOR
      AUTHOR
      all to gain
      No Mood

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      never trust a doctor
      So we are still 10+ years off anything that treats tinnitus?
       
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    23. lcj

      lcj Member Podcast Patron Benefactor

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      • Informative Informative x 1
    24. FGG

      FGG Member Podcast Patron Benefactor

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      Correct, used as a urinary acidifier to help prevent (certain types of) recurrent urinary stones.

      I wonder if phase 3 was discontinued because it is widely available (through veterinary prescription anyway) and therefore funding without hope of recouping profit would be hard to get.

      I would like to read the phase 2 results.
       
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    25. FGG

      FGG Member Podcast Patron Benefactor

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      • Informative Informative x 2
    26. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

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      • Agree Agree x 1
    27. OnceUponaTime
      Frustrated

      OnceUponaTime Member Podcast Patron Benefactor Hall of Fame

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      Ugh...one of the many reasons I do not follow any particular treatment. :( I'll wait for Markku to blast it on the front page when we get one. sigh.
       
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    28. FGG

      FGG Member Podcast Patron Benefactor

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      Sorry, this was about D-methionine
       
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    29. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

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      I think there are different forms of it, not sure if this one is over the counter.
       
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    30. Caveman

      Caveman Member

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      2015
      Cause of Tinnitus:
      Unknown
      The DL-form is over the counter.
       

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