Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Then nothing! You can try it out if you want then. I've tried a few supplements that haven't helped me much but not this one.
       
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    2. Auron
      Dead

      Auron Member

      Location:
      Planet Earth
      Tinnitus Since:
      Spring
      Cause of Tinnitus:
      Acoustic Shock
      Wait is the pill Hough Ear Institute is working on only to prevent damage? Seems like it. Looks like it's nothing more than NAC wrapped with a pretty bow on top.
       
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    3. vttbx

      vttbx Member Benefactor

      Tinnitus Since:
      01/2001
      Unfortunately, D-Methionine is not available to the general public. All the research done on hearing was using D-Meth, not L-Meth. DL seems to be for pets only. If you want to take a deep dive, watch this video with Dr. Campbell who was in charge of the study. It's from 2011 and the audio is out of sync. She mentions @26:06 that D-Meth is safer and stays in the body longer than L-Meth.

      SIU Tech Expo 2011: D-methionine (D-met) as a...
       
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    4. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      Except that they’re also saying it has the effect of repairing ribbon synapses.
       
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    5. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      I did scope out their publications... super.
      You are right... they’ve got a lot of stuff going down... it's amazing they can’t come up with money... the Hearing Health Foundation could promote their cause. The Bill Gates Foundation could float them for the next decade...

      It’s actually chump change they are after... I don’t get it...

      Dark days... hope to see a flicker of light...
       
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    6. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Wrong. It was shown to repair damage, and it's not only NAC in it. AND they're working on an injection as well to regrow hair cells.
       
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    7. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      We’re also gonna need something for regrowing spiral ganglion neurons. I believe Rinri’s stem cell drug is for that but honestly I find it hard to distinguish between those, ribbon synapses and the ‘auditory nerve’. Wish an ENT could explain it in laymen’s terms.
       
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    8. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      ENTs probably know less than you buddy
       
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    9. Caveman

      Caveman Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Unknown
      Is Rinri's drug even in pre-clinical phase??
       
    10. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Even with hair cell regeneration drugs?
       
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    11. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      Yes, if you don’t have any hair cell damage, but do have damaged spiral ganglion neurons. If you look at donated temporal bones of people with sudden hearing loss for example, some people were in that category. Most did have hair cell damage though.
       
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    12. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      It is. They’re hoping to get to Phase 1 within 5 years.
       
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    13. AUTHOR
      AUTHOR
      all to gain

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      dirty drugs
      I don't understand the science, can you explain it to me?

      My tinnitus is from ototoxic drugs (possibly stress too), which was then worsened by an MRI.

      Where does this leave me?
       
    14. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      I know right! However, it is not that easy, especially with patents and proprietary methods/compounds at stake. Biotech firms (for-profit) are interested in making money primarily. As they should - that is what has given us so much medicine. It is a good model. It is just frustrating for those of us that suffer while we wait for something to ease our suffering to get approved.

      We are a non-profit. Our focus is on the mission, to restore hearing worldwide through research, education, and humanitarian efforts. Profits that are due to Hough Ear Institute go right back into research to help others suffering. That is the primary difference between us and many other outfits: we have the mission as our primary objective and bring in for-profit biotech firms to aid us in accomplishing that mission.
       
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    15. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      I honestly wouldn't know. I'm not a scientist or a doctor. However, that would be a great question when we get Dr. Rick Kopke on the Tinnitus Talk Podcast!
       
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    16. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      I work at the Hough Ear Institute.
       
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    17. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      Thank you and yes. That sums it up nicely.

      Also, for your information and to keep in mind - I moved my family (wife and 7 kids) to OKC to advance the research. I'd like to think that I did that with a degree of understanding of and belief in the science and ultimate goal of commercialization.
       
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    18. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      Less than the cost of a single hearing aid!!!!
       
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    19. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      We are open to any route that leads to commercialization so we can bring relief to hundreds of millions of people around the world!
       
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    20. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      Caveat - I'm not a scientist. This is a great question and should be asked during the Tinnitus Talk Podcast.

      That said, I believe your question is more related to our hearing loss injection technology, not the hearing loss pill.

      The pill regenerates meaningful connections between the auditory nerve, the nerve endings, and the cochlea. Once those connections and re-established there isn't a need to continue the medicine. It may need to be taken again if there is additional trauma resulting in additional nerve damage.
       
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    21. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      Great question. You guys know more about the science that I do. I'm still learning. This would be a great question for the podcast - as I have no clue how to answer it :)!
       
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    22. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      Phase II will cost anywhere from $50-100 million. That said, once we get it through Phase II and we know it is safe AND that it is effective - more biotech firms will be interested in investing, licensing the tech, and pushing it through Phase III.

      Our business model relies on contributions for the initial research and Phase I, possibly Phase II clinical studies then a commercialization partner to take it through Phase II possibly, and Phase III clinical studies.
       
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    23. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      We have reached out and we have received funding. Our latest government grant was the only one approved by the DoD and funded out of over 70 applicants.

      The challenge is that government funding is slow!!!!! Our research has outpaced government funding.
       
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    24. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      Maybe you just need some more coffee:) You want publications? Ok, here you go: https://houghear.org/publications/
       
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    25. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      Correct.
       
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    26. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      Hopefully not! Our goal and we are currently on track, is mid-2020's.
       
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    27. Justin De Moss

      Justin De Moss Member

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      It was initially developed for prevention. We discovered however that it was restorative as well. Then we discovered it was effective in treating tinnitus. Initial research is so much fun once you get past all the failures:)
       
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    28. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      It is also looks like the research was as a prophylactic or immediate after noise exposure (within 7 hours).

      Her talk was illuminating in regards to DoD funding though.

      "They are only interested in oral formulations because they can be used on the battlefield."

      Other things she said make it sound like they are less interested in helping already disabled veterans and more interested in preventing future ones. Would be nice to see DoD research addressing both.

      Edit: D-Methionine probably needs its own thread.
       
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    29. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      I'm assuming we don't have the tech to differentiate or diagnose those aspects on a live person?
       
    30. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Justin I've read you saying this a few times - it's effective in treating tinnitus. Is this based on findings from animal models or humans who reported it after phase 1?
       
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