Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. jeff W

      jeff W Member

      Location:
      nakatomi plaza
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      04/2012
      That's not correct. Age causes changes in the composition of auditory and vestibular nerves over time indeed this would seem to be the case for all the cranial nerves possibly with the exception of olfaction, NASA funded work into this a long time ago, they showed that the nerve health peaks at puberty and then begins to change slowly over time, theoretically these changes interfere with action potential conduction quality/clarity, add onto that some pathogens and HC damage and you have a setup for a hearing loss. Schuknecht also examined this sort of things in cat models over many years, bashing them over the head and inspecting the distinct types of cochear damage that resulted. The real issue is the amount, the amount of noise is just too much for modern human ears. Its an industrial issue, I have read that people who live near airports can have lower scores on basic cognitive tasks than age matched controls who live in the more sedate areas, others refute this data, it is quite frightening. It is put much more eloquently below.

      25488408_1786791431332133_1851545849654279595_o.jpg

      https://www.docdroid.net/cdzeIoR/
       
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    2. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
       
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    3. Autumnly
      Wishful

      Autumnly Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Noise-induced
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    4. Berik

      Berik Member Benefactor

      Tinnitus Since:
      11/2016
      Cause of Tinnitus:
      Unknown
      https://alliancerm.org
      "Alliance for Regenerative Medicine "
      Someone from Tinnitustalk attending? Curious if FX amongst others will bring some news.

       
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    5. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      Where do you see that the topics include hearing restoration?
       
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    6. Autumnly
      Wishful

      Autumnly Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Noise-induced
      You can view their agenda here. Frequency Therapeutics is mentioned as one of the presenting companies (8:55am - Company Presentations).
       
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    7. spingee
      Wtf

      spingee Member

      Btw there was no update from Standford initiative for hearing loss cure for a year.
      Hope they are just busy with some breaktrhrough
       
    8. Champ
      Woot

      Champ Member Benefactor

      Location:
      Boston, MA
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      01/2013
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      Acoustic trauma from headphones
      I wouldn't put too much stock on any college making a breakthrough for a cure. The companies working on this stuff are far more likely to come to a working solution since real-world capital is on the line. College researchers if anything will try to drag out their work as long as possible to cover as much material as possible to justify their existence. It will definitely provide valuable data and insights but companies will be the ones solving this problem.
       
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    9. Aaron123

      Aaron123 Member

      Tinnitus Since:
      00/0000
      Cause of Tinnitus:
      Irrelevant
      Interesting paper with a new twist on delivering drugs to the inner ear - particularly to repair synapses and preserve spiral ganglion neurons: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.8b00022

      The idea is binding neurotrophins (which have been shown to restore synapses in animal models) to small molecules that bind to bone. Thus they are taking advantage of the fact that the cochlea is encased in bone to increase the amount of time the drug is in the inner ear thus hopefully increasing its effectiveness.
       
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    10. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      I was only able to see the abstract. Do you know what their plans/timeline are for the development/testing of these molecules?
       
    11. Aaron123

      Aaron123 Member

      Tinnitus Since:
      00/0000
      Cause of Tinnitus:
      Irrelevant
      This is basic scientific research done with extracted cochlea (i.e., it was not done in living mice). No plans are given in the paper, but presumably they will test on (living) mice models of synaptic damage and go from there. So likely years.
       
    12. rsmcfar

      rsmcfar Member

      Tinnitus Since:
      02/28/2014
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    13. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      The article referred to it as a
      Would the fact that this basic research is being done universities delay a possible drug to market?
       
    14. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      All we need is one of the hearing loss companies like Decibel or Frequency to take this information and run with it. The research the universities do shouldn't delay the drug to market. I'm pretty sure they share all of the information they gather with everyone so any of the companies is free to pursue this method further.
       
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    15. Margus

      Margus Member

      Tinnitus Since:
      01/2015
      Cause of Tinnitus:
      Unknown
      They write in the article "Inside this part of the ear, there’s fluid constantly flowing that would sweep dissolved drugs away...". I wonder how Frequency or Decibel are addressing these issues? I guess phase 1 trial from Frequency was about to find it out, but from the article it seems that we should not really expect to find any traces of drug in inner ear for long time.
       
    16. grate_biff
      In pain

      grate_biff Member Benefactor

      Location:
      Moss, Norway
      Tinnitus Since:
      09/2014
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      Thats why they have their compound in gel form, slowly diffusing through the round window.
      And yes, phase 1 was about finding out concentration levels, over time. And according to them it was a success!
       
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    17. reggie green
      Balanced

      reggie green Member Benefactor

      Tinnitus Since:
      03/08/2001
      I guess we drug would need to be apply again after it wash away,
       
    18. grate_biff
      In pain

      grate_biff Member Benefactor

      Location:
      Moss, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma using headphones
      That we will know after phase 2 trial is completed, but for now they have seen pre-clinical results after just one administration. It depends, I would think, of your initial presence of progenitor cells.
       
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    19. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
      Did anyone read anything about cgf166 expanding their trial to other types of hearing loss?

      Speak of the devil, this from Lust1g and St@ecker.

       
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    20. Stev

      Stev Member

      Tinnitus Since:
      Feb 1, 2018
      Cause of Tinnitus:
      Noise Induced
      This is a huge deal right??? Is it not? I feel like we should be pretty stoked about this. Has there been anything else like this where hair cells are regenerated in mammals? Am I missing something here???
       
    21. parsky

      parsky Member

      Tinnitus Since:
      8/1/17
      Cause of Tinnitus:
      Unknown
      Definitely good. The rubber meets the road when they do human trials though. Sometimes things don't work on humans that worked in other animal models. Exciting none the less
       
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    22. tomytl
      Grumpy

      tomytl Member Benefactor

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    23. ee9892

      ee9892 Member

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      2015
      Cause of Tinnitus:
      Life
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    24. Berik

      Berik Member Benefactor

      Tinnitus Since:
      11/2016
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      https://clinicalgate.com/noise-induced-hearing-loss/#bib33
      Anybody any details about this study? Can only find it behind paywalls. Curious how much "substantially impoved" is.
       
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    25. Berik

      Berik Member Benefactor

      Tinnitus Since:
      11/2016
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    26. Apolonia
      Disappointed

      Apolonia Member

      Location:
      Croatia
      Tinnitus Since:
      December 2017
      Cause of Tinnitus:
      Noise induced, acoustic trauma
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    27. Autumnly
      Wishful

      Autumnly Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Noise-induced


      From the video, starts at 2:40
      Pill - Hidden Hearing Loss & Tinnitus
      • a pill that in preclinical models seems to be very effective at treating tinnitus (not mentioned whether acute and/or chronic t)
      • seems to regrow the nerve endings in the inner ear
      • may be able to restore hearing
      • has been through Phase 1
      • ready for Phase 2
       
      Last edited: May 1, 2018
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    28. Apolonia
      Disappointed

      Apolonia Member

      Location:
      Croatia
      Tinnitus Since:
      December 2017
      Cause of Tinnitus:
      Noise induced, acoustic trauma
      Is this really a real thing??? Don't wanna be a pessimist, but it looks too good to be true...
       
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    29. ee9892

      ee9892 Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Life
      Ill huff this dudes farts everyday for the rest of my life if they can bring forth that pill.

      Thats some great news.
       
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    30. Autumnly
      Wishful

      Autumnly Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Noise-induced
      There are still many things we don't know about this pill:
      • whether it only works for acute or chronic tinnitus
      • whether it works only for a subgroup of sufferers or several subgroups
      • how big the therapeutic window is
      • don't forget: Phase 1 success rate: approximately 70%, Phase 2 success rate: approximately 33%
      • other companies working on a drug for hidden hearing loss: Otonomy, Affichem, Bionics Institute and University of Melbourne,...

      In this article (RNA Injection Restores Hearing in Guinea Pigs, Hough Ear Institute) it says
      • "As damaged hair cells in general cannot repair themselves, he explains, they’ll die relatively quickly. At that point, regeneration is the only option to recover hearing. He says that lengthening the time between the damage and the initiation of treatment to a month, which would give damaged hair cells time to die, would help distinguish between repair and regeneration."
      Wouldn't that mean that hidden hearing loss would turn into "actual" hearing loss (meaning the death of the hair cell) within a month? But I've read somewhere in this thread that damaged hair cells could potentially survive for years (I think)...
       
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