Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. PDodge
      Cowboy

      PDodge Member Benefactor

      Location:
      Woods of Alberta
      Tinnitus Since:
      01/2017
      Cause of Tinnitus:
      Bear ate my Cochlea
      Yes!?! Go Charles(s)
       
    2. Deathtotinni

      Deathtotinni Member

      Location:
      Parkville Maryland
      Tinnitus Since:
      9/10/17
      Cause of Tinnitus:
      Qtip and maybe a sound..who knows
      It might man.
       
      • Agree Agree x 3
      • Optimistic Optimistic x 1
    3. ruben ruiz

      ruben ruiz Member

      Location:
      Tucson, AZ
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I believe it was meds and stress
      Is it true that the current USA administration has outlawed adipose stem cell therapy?
       
    4. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      no.
       
      • Agree Agree x 2
    5. Deathtotinni

      Deathtotinni Member

      Location:
      Parkville Maryland
      Tinnitus Since:
      9/10/17
      Cause of Tinnitus:
      Qtip and maybe a sound..who knows
      These threads have been quiet the last couple weeks. We’re all just waiting to see what the result of the clinical trial will be. lol
       
    6. Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      you do realize that slight, mild, moderate, severe, and profound are all outdated normie ways of classifiying SNHL. Those terms were purely based on tonal audiometry statistics.

      Most hearing loss cases have to do with audiotory nerve fibers not connecting with hair cells not hair cells dying. Hair cells don't die until after the synaptic ribbons go. So the normie inducing noise trauma would have to have experienced muffled hearing first and not of cared.

      Look at Decibel Therapeutics and Otonomy they are working on getting new ribbon synapses to connect to hair cells which will improve speech in background noise and clarity of music.

      Regenerating hair cells in my case would probably give me useless frequencies above 14k that do not match my tinnitus tone. (accept when I yawn loud). I do perfect on a DPOAE and tonal audiogram.


      You should know this manny.
       
      • Informative Informative x 2
      • Like Like x 1
    7. Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      I'm still waiting for confirmation that growing new hair cells will repair pre-existing damaged hair cells with less synaptic ribbons. That will make me excited if it can be confirmed.
       
      • Agree Agree x 4
      • Like Like x 2
    8. Manny
      Dead

      Manny Member Benefactor Hall of Fame

      Location:
      United States
      Tinnitus Since:
      1/2018
      Cause of Tinnitus:
      central gain << NIHL
      I agree what you wrote, but I'm not sure what your point is in relation to the above.
       
    9. PDodge
      Cowboy

      PDodge Member Benefactor

      Location:
      Woods of Alberta
      Tinnitus Since:
      01/2017
      Cause of Tinnitus:
      Bear ate my Cochlea
      I could have sworn I read a study about stem cells and ribbon synapses last night... I can't find it again though.
       
      • Informative Informative x 2
    10. Enclave

      Enclave Member

      Location:
      Meh
      Tinnitus Since:
      Meh
      Cause of Tinnitus:
      Meh
      • Informative Informative x 4
      • Like Like x 1
    11. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      • Like Like x 3
    12. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      From the article:
      "Supporting cells began to proliferate and started the process of activating other neighboring stem cells to lead to “apparent supernumerary hair cell formation,” and these hair cells’ integration with the network of neurons was also supported."
      So integration was supported means that the regenerated hair-cells connect to cochlear nerve?
       
      • Good Question Good Question x 2
    13. Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      We keep talking about this, and I keep repeating myself. What good is hair cell regeneration when most hearing deficits has far more to do with hair cells losing nervous tissue, not hair cells dying.

      I already believe most people that are having hearing problems already have a sustainable cochlear hair cell population, it's just that the hair cells lack synaptic ribbons (nervous tissue) so music and speech in background noise sounds like shit. If this is the case hair cell regeneration will probably only be effective in *moderate cases of hearing loss and onward. It could even be that total deafness in a frequency range could be caused by totally denerved hair cells not dead ones.

      *the clinical definition of "moderate hearing loss" actually means your are half deaf and is far from any rational definition of the word "moderate"

      @JohnAdams already showed me some research papers that said new hair cells would not grow in regions that were preoccupied with existing hair cells, so oh well we can't use the argument "but new hair cells will make up for damaged ones"
      John can you please cite these papers.

       
      • Winner Winner x 2
      • Informative Informative x 1
    14. Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      Hair cell regeneration will help more severe forms of hearing loss where there is total deafness in a tone played at specific db, AKA bad enough to show up on the outdated tonal audiogram. I mean maybe if I get 10 db of hearing back it would help, I just can't help but be skeptical.

      Hearing shouldn't be measured by tonal db in silence, but rather how well one can decipher a range of frequencies in complex background noise.
       
      • Agree Agree x 2
      • Winner Winner x 1
    15. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      @Contrast ...

      So you’re saying this therapy can only work if they actually find a way to kill all cells (at a certain frequency) to level the ground and cultivate fresh ones?

      Ototoxicity may come in hand after all?

      Oversimplifying and a bit of sarcasm here... but the remark is valid:

      Would this therapy perform better with a level playing field / cochlea?
       
    16. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Or both. But certainly the speech recognition part first.
       
      • Like Like x 1
    17. Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      I stand corrected speech in quiet and tonal audiometry should be done along side test for background noise deciphering. The whole idea is the test needs to be far more focused on how well one hears in various background noises.
       
      • Like Like x 1
    18. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      yeah I knew what you meant. actually you're the one that made me aware of the ineffectiveness of pure tonal audiograms vs speech recognition in noise tests.

      but how does that help sell hearing aids to the stupid cattle?
       
    19. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      Everyone talks about Frequency and FX-322 as the first regenerative treatment to expect on the market. That's if it doesn't fall over in a heap at the second hurdle.

      But it's quite possible that Audion and the Regain project may get there sooner, again assuming it too doesn't fall over. At least in Europe. It won't have to contend with convoluted FDA bureaucracy. That must be worth some kind of time saving. Ah...but so many assumptions!
       
      • Agree Agree x 2
    20. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Seems to be the one most talked about, I thought Otonomy would be an emerging player targeting hidden hearing loss and synapse repair.
       
      • Agree Agree x 2
    21. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      Yes Otonomy too, though I think they may be still one phase behind in the regeneration race.
       
    22. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      Four players!
      Four real chances...

      I believe the odds on us getting a cure in the next 3-5 years have been worse.
       
      • Optimistic Optimistic x 1
    23. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Just 4???
       
    24. Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      audion and regain are using a less effective method to regenerate hair cells.

      A complex gene therapy vs working with the bodies natural progenitor cells.
       
      • Agree Agree x 1
    25. Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      hidden hearing loss is the larger problem then traditional hearing loss.
       
      • Agree Agree x 3
    26. Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      Hidden hearing loss is just the reality of how the inner ear gets damaged and loses it's ability to listen in complex noise environments.
       
      • Agree Agree x 1
      • Winner Winner x 1
      • Informative Informative x 1
    27. Marko Nakovski
      Bored

      Marko Nakovski Member Benefactor

      Location:
      North Macedonia
      Tinnitus Since:
      27.04.2017
      Cause of Tinnitus:
      Loud music
      @Contrast If they manage to improve the hidden hearing loss will that improve hyperacusis too? What do you think about that?
       
    28. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      so why is it called fx-322? were there 321 previous prototypes or something???
      the number 322 seems kinda arbitrary.
      ;)
       
      • Good Question Good Question x 1
    29. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      Audion are using the principles of Notch inhibition and admit to wanting to regenerate a small number of cells. For many this will be enough to positively alter psychological well being. If it's only 10 db and only in a certain frequency, so be it.

      The complexities you mention may well be crucial to a truely successful process.

      But at this point in history, the emergence of a lone, crinkly, motherless hair cell, coaxed into dutifully relaying a signal as it was born to do, will be greeted with all the joy of the Prodgical Son come home.
       
      • Agree Agree x 2
    30. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      • Like Like x 2

Share This Page

Loading...