Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      No.

      It also sometimes fades (brain filters out tinnitus perception)
       
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    2. Telis

      Telis Member Hall of Fame

      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Drugs barotrauma
      I think it’s rare-we aren’t talking age related, genetic etc. How often does someone with hearing loss due to acoustic trauma actually not have tinnitus? I’m talking measurable permanent hearing loss after say a blast injury, this kind of injury happens with no tinnitus? I have no idea, but I’ve never heard of a major trauma including permanent hearing loss with no tinnitus to follow.
       
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    3. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      Hearing loss by itself may or may not give you tinnitus. Anxiety is one of the triggers. There are so many factors... For most people just putting a hearing aid in will drop tinnitus levels within seconds or minutes. The brain can rewire itself. I had hearing loss with hearing aides and that kept tinnitus away for many years until the hearing aides couldn't compensate anymore and I had anxiety.
       
    4. PeteJ
      Depressed

      PeteJ Member

      Tinnitus Since:
      02/2019
      Cause of Tinnitus:
      acoustic trauma?
      Lots of people have anxiety but don't have tinnitus?
      How did the hearing aid keep it away?
      Define 'keep it away?'
       
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    5. PeteJ
      Depressed

      PeteJ Member

      Tinnitus Since:
      02/2019
      Cause of Tinnitus:
      acoustic trauma?
      Ok. Is there any reason why it wouldn't have potential?

      I thought they were hyperactive because of a lack of 'healthy tissue/auditory system.' Restore it sufficiently and perhaps the brain can rewire and 'message' the neurons to 'calm down?' I guess I am just hoping it's not much more complicated than something like that.
       
    6. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      I had anxiety/depression 3 times over the past 10 years. It was the third time that I finally got T. There is no one answer fits all. Its a combination of hearing loss, maybe age, anxiety, anxiety levels, etc etc. There are many factors that can go into when a person finally gets T

      The hearing aid corrects the frequencies to get you back to normal hearing. Again, doesnt fit everyone, but a hearing aid can keep you from getting T if you can correct all the frequencies before the T starts. If your brain is sensing normal hearing you won't trigger Tinnitus. Everyone is different. Some people get T with a small loss at 12k. Other people get it after huges losses after many years. There isnt a specific trigger and everyone is different.
       
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    7. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      What do you mean by "corrects the frequencies"?
      Change the pitch? Amplify? Attenuate?
       
    8. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      Think of a hearing aid as a glorified multi band equalizer.

      It amplifies the frequencies where you have hearing loss such that the resulting sound, combined with your hearing loss, sounds like the original source.

      The pipeline looks like this:

      Signal 1 => Hearing Aid => Your Loss => Signal 2 Perceived by your brain
      The HA is configured based on your loss data (from your audiogram) such that Signal 2 approximates Signal 1 as faithfully as possible.
       
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    9. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      Yes, as Greg mentioned. If you have a 50db loss at 8k, the hearing aid will try and amplify the loss by that amount so you get to as close to 0 as possible on the hearing chart. I wore my hearing aides for 20 plus years and did not get T because the hearing aide amplifies the frequencies and I have extreme hearing loss. At one point though once you hit 70 to 80db loss you can no longer amplify the sounds that much as your ear can't take that much amplification so it must be turned down. Once that happened plus anxiety is when I got T. My daughter with very very little hearing loss but lots of anxiety got T at 16. As mentioned we are all different.
      I can't get rid of my T completely anymore, with hearing aides but again I think it is because I can't get back to baseline. There is a direct correlation between the amplification, I can adjust it, and the amount of T I have though. I can change the volume up and down and wait seconds to minutes and see the T go up and down in that exact amount. Our brains are plastic. Any hearing regained will lower T volume. There is still hope.
       
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    10. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      But they can´t amplify frequencies over 10 kHz can they?
      So it would be of no use to us with HF loss!
       
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    11. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      It depends on the models. It is true that it is very rare to get good amplification over 8 kHz, but I've read about a model (I think Siemens) that goes up to 12 kHz.

      It depends what you call HF hearing loss. My hearing loss is a slope that goes from "good hearing at 1 kHz" to 50 dB losses at 8 kHz, that you can easily extrapolate to tons of losses in the octave above 8 kHz (I did do an extended hearing test with PTA above it, and it did show bad losses above 8 kHz).

      While my current HAs can't help fill in the blanks very high in frequencies, I still have enough losses above 2 kHz to make them useful.
       
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    12. Ryzen

      Ryzen Member

      Tinnitus Since:
      06/2018
      Cause of Tinnitus:
      Began after a single night of wearing Bose Sleepbuds
      I'm confused; how is regenerating hair cells enough when there's other parts of the puzzle, like loose synapses?
       
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    13. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Dr. Robert Jackler from Stanford University has stated that when the hair cell is regenerated that the nerves regrow and reconnect to the supporting cell. He described it as a "God-darned miracle".
       
      Last edited: Mar 22, 2019
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    14. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      Sounds like more proof to me that if you fix hearing loss, you at least have a chance to fix Tinnitus.
       
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    15. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      Seems like a logical effect.
       
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    16. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
      I also think if there would be sounds again for the brain, that T would fade.
      Everytime I got glogged ears du alergies or a cold T increase like crazy.
      Just let us pray,that Audion or Frequency can achieve some measureaböe resuöts.
      That would open a conpletly new platform .
       
    17. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
      an Interview with Hough Ear CEO about a Pill and Injection to treat hesring loss and Tinnitus. I wish there would be much more information about, it looks like they doing very independent research.
       
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    18. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      This is why this thread is so important. I don't believe you can fix tinnitus without fixing hearing loss. At best they might be able to develop a pill that would suppress it for 4 to 6 hours at a time, but if the hearing loss remains the tinnitus will remain. I also believe that in order to completely get rid of tinnitus you have to get 100 percent of your hearing back across all frequencies once it has established itself in the brain.

      I'm also excited about the multiple dose approach because most of the research has pointed that a single dose isn't going to get you back to 100 percent. If multiple doses can and the process can be repeated, then we have a shot at getting rid of tinnitus. Even monthly or yearly injections would be a good thing since our hearing continually deteriorates due to age or rock concerts.
       
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    19. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      I think you only need to round out the "dips". That is what the brain reacts to.
      Look at my avatar and take a guess why I only have (high pitch) tinnitus in my right ear?(Red is right ear, blue is left)
       
      Last edited: Mar 22, 2019
      • Good Question Good Question x 2
    20. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      "our hearing loss pill, which is expected to be approved by the FDA by the early 2020s!"

      Also in this interview Dr. Kopke states he expects the injection to regenerate hair cells to get FDA approval mid to late 2020.

      That to me sounds to good to be true.
       
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    21. GSC
      Volatile

      GSC Member

      Tinnitus Since:
      02/2019
      Cause of Tinnitus:
      Acoustic trauma.
      Oof. This has me moist.
       
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    22. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      That's a long time. Why the damn hold up?
       
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    23. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      They are overtaking Frequency Therapeutics and Regain :dunno:
       
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    24. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      In order for 2020 to happen they would have had to have been in clinical trials already and unless someone can find it they are not. They always make claims they can't support. Early 2020 is less than a year away. Don't anyone get their hopes up over this.
       
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    25. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      Did he suggest the 2020's, as in sometime during the next decade, or during the actual year 2020?
      A bit of a difference! I think he meant the former. Next year is hard to believe.
       
      • Good Question Good Question x 3
    26. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      What injection? Do they already have it?
       
    27. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
      Yes they often sound like they are close to a cure for hearing loss. I looks that they are cooking their own soup.
      In the other hand it‘s not a fake organisation and the are arround for a long time.
      They probably work together with the US Army, at least with their bomb blast pill
      In the other hand, Otologic pharmaxeuticals, where Kopke is also CEO has aquired the regeneratiön technology.
      http://www.bioworld.com/content/series-round-sets-otologic-pharmaceuticals-hearing-loss-pill-path-clinic

      But at least Accele Bio‘s Webpage doesn‘t exist anymore... and the Otologic Pharmaceuticals Page is also always at the same stage ....

      I‘m always in doubt with them.

      Sound Pharma is also on delay again, they also should announced to bring their regeneration compound forward....
      but they also wrote in 2003 in a wall street journal that in 2015 they will have hair cell regeneration and then will move to eye-regenerative medicine.... at now, they still in Phase 2 with some not regenerative compounds.... so you see, timetables are very relative. Most is said to attract investors I think.

      Anyway, good thing is Regain of Aufio and Frequency‘s trials, so will see hopefully soon if there is some promising regeneration in a human inner ear.....
       
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    28. Ray552

      Ray552 Member

      Tinnitus Since:
      12/18
      Cause of Tinnitus:
      Noise trauma
      Hopefully by summer Frequency Therapeutics has something that we can hold our hopes on, once we have potentially good results and a date the countdown can begin to get our lives back hopefully.
       
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    29. fade2black244
      Inspired

      fade2black244 Member Benefactor

      Location:
      TX
      Tinnitus Since:
      03/24/2017
      Cause of Tinnitus:
      Noise Induced
      Sounded like when he said "early 2020's" he meant more of like 2021-2024ish than 2020.

      Taking a pill as a treatment would be a dream at this point. Just imagine taking the T pill plus layering it on top of the lasting effects of (one day) successful bi-modal stimulation. Then, a cure a few years later.

      There are plenty of reasons to be hopeful.
       
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    30. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
      Concerning the research of Hough Ear they published their findings in several papers
      https://www.google.ch/amp/s/www.the...ion-restores-hearing-in-guinea-pigs-30855/amp

      https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(18)30112-6.pdf


      So it looks more less with substance.
      RNAi & siRNA approach is sonethibg many conpanies put resesrch in it, bur öast yesr Alnylam Therapeutics got as rhe first conpany FDA approval for RNA Therapy.
      So st least the technology itself looks applicable on human.
      I think this will be the key, some working approaches where you can use for some specific targets.
       
      Last edited: Mar 23, 2019
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