Intratympanic Injection of Steroid for Treatment of Tinnitus

Discussion in 'Research News' started by ajc, Dec 19, 2019.

    1. ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      https://www.ncbi.nlm.nih.gov/pubmed/31750136

      Tinnitus has become one of the most challenging tasks faced by the medical field. It has a moderately negative impact on patient's quality of life. Different methods had been developed in medical science for managing tinnitus but none of these offered a permanent cure.

      In our study we used a simple procedure of intratympanic injection of dexamethasone in managing our tinnitus patients.

      Total number of patients involved in this study were 40, 26 females and 14 males with age spanned from 15 to 65 years. Out of 40 patients, 22 of them complained of tinnitus only while the other 18 of them complained of tinnitus with impaired hearing which was confirmed further by pure tone audiometry.

      Injection was given under otologic microscopic vision through posteroinferior quadrant of tympanic membrane in weekly interval.

      After receiving several number of injections, 24 patients (60%) reported complete disappearance of tinnitus, 10 of them (25%) still had residual tinnitus but comparatively less severe and 6 (15%) of them reported no improvement.

      @mrbrightside614
       
      • Like Like x 5
      • Winner Winner x 2
    2. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      This is an extremely clear cut one, nice! I’m going to use this thread as a pool for various steroid treatments and write up a summary for each. Then we can sift through everything and set up a general format by which we can insert different therapies under different headings.

      Gotta lift though and get that BDNF up first boys!
       
    3. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Maddening that this was not offered to hardly any of us while we were in the acute stage. Simply maddening.

      The most effective therapy for acute noise damage, with plenty of science to back it up, not offered. That's 100% bullshit.
       
      • Agree Agree x 3
    4. all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
      -
      Cause of Tinnitus:
      -
      That sounds very promising. How many injections did each participant get in total? And for how long did the tinnitus remain 'gone'?

      I wonder how severe the participants' tinnitus was. I don't like, "It has a moderately negative impact on patient's quality of life." May be for some, but as we know this is not true for all.

      Dexamethasone seems to have quite a lot of side effects though (from a quick Google search).

      See it was an Indian study.


      Does it only work in the acute stage? It's not mentioned going by the link. And did the participants all have tinnitus from noise damage? I hope it does something for tinnitus caused by ototoxic reactions as well.
       
    5. Rafaa

      Rafaa Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Who knows? I have Patulous ET and ETD + Other things
      Only thing is how can I get an ENT to inject me with it? I have inflammation in the eustachian tube closer to the middle ear so nasal sprays won't get in there. An injection would.
       
    6. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Yes.
       
    7. AUTHOR
      AUTHOR
      ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      Here is the FULL ARTICLE of the study I linked to in my original post.

      Recent onset tinnitus cases got maximum benefit.

      @mrbrightside614 @JohnAdams
       

      Attached Files:

      • Like Like x 2
      • Informative Informative x 1
    8. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I can't even think about this. This should be the absolute first thing any doctor or ENT offers a patient with a recent acoustic trauma and tinnitus, but it isn't. Very few things actually make me mad and this is one of them.
       
      • Agree Agree x 4
    9. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      Keep in mind this is just one research study. Others have shown a not-so-clear correlation with complete tinnitus remission, while others use oral steroids in conjunction. The overarching theme that is emerging seems to overall be “steroids = good”. I’ve not found one that specifically compares IT Dex vs. oral steroid, let alone one with a control group added. This makes it hard to evaluate and a proper review will rely on a lot of cross-referencing.
       
    10. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      What study?
       
    11. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      The OP from @ajc.

      I’ll start logging my search queries and scholarly sites used so they can be referenced if we decide to write the review.
       
      • Like Like x 1
    12. just1morething
      Benevolent

      just1morething Member Benefactor

      Location:
      U.S.
      Tinnitus Since:
      It started
      Cause of Tinnitus:
      Bad luck
      I had IT injections of dexamethasone years ago. I don’t think they do them much anymore. I could check with Shea and see what they offer now. I was there in 2011. I was to Paparella in 2010 and had 3 dexamethasone injections spaced about a week apart in my left ear only.

      I see that report was from India. Maybe dexamethasone plus PRP would be better?
       
    13. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I had that.
       
    14. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      Undoubtedly yes but the chances of IT PRP becoming common practice before specifically targeted therapies like FX-322 arrive in the marketplace are slim to none. That’s why we’re focusing on steroidal therapies for the treatment of acute tinnitus/acoustic trauma.

      Despite the observation i made in the first statement maybe the availability of such a therapy would keep FX-322 pricepoints in check. This could be worth advocating for but would need considerable research worthy of an entirely different review subject altogether.
       
    15. just1morething
      Benevolent

      just1morething Member Benefactor

      Location:
      U.S.
      Tinnitus Since:
      It started
      Cause of Tinnitus:
      Bad luck
    16. RishRamsey
      Doubtful

      RishRamsey Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Stupid DJ
      My ENT prescribed oral prednisone 36 hours after the onset of my tinnitus (acoustic trauma from loud club). I started taking it and took it for a 3-4 days. I think it helped in the beginning with the volume but I started losing sleep (now I think because of the anxiety and all the stuff I read on the internet). I again read of people not benefiting from it and some reports saying it caused them suicidal thoughts and lack of sleep which was happening to me as well (I now really believe it wasn't from the prednisone but the initial tinnitus trauma). As a result, I threw mine away and hence, here I am with blaring tinnitus.

      Maybe it would have helped if I'd done a complete course of 2-3 weeks, maybe not, but I should have completed it. One of the things I really regret doing after I got tinnitus. :(
       
    17. just1morething
      Benevolent

      just1morething Member Benefactor

      Location:
      U.S.
      Tinnitus Since:
      It started
      Cause of Tinnitus:
      Bad luck
    18. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Yes. That was potentially a mistake.
       
    19. Shaqz

      Shaqz Member

      Tinnitus Since:
      12/10/19
      Cause of Tinnitus:
      Acoustic Trauma
      My tinnitus started on December 10th 2019. Am I still in the acute stage?
       
    20. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      What did you do so far? Did you go to an hospital, a tinnitus clinic?
       
    21. Shaqz

      Shaqz Member

      Tinnitus Since:
      12/10/19
      Cause of Tinnitus:
      Acoustic Trauma
      @Frédéric Yea and I have severe tinnitus as they explained to me at the clinic and put me on sound therapy and benzos... my tinnitus came from ototoxicity and I will do anything to fix it.
       
    22. Jack V

      Jack V Member Benefactor

      Tinnitus Since:
      1/2020
      Cause of Tinnitus:
      Something Wicked This Way Comes
      Thanks for posting that.

      The lack of specificity suggests the quality of the research is not top notch. For example, it states: "In 15% of cases no improvement in tinnitus was observed and most of these patients who received no benefit had experienced tinnitus for long duration." However, it doesn't define "long duration" (2 months? 10 years?), or anything about durations or severity for anyone. Of the 60% who recovered, for example, was their tinnitus recent and mild and might they have recovered anyway? That the study begins by declaring the impact of tinnitus on quality of life only "moderately negative" could suggest patients with only mild cases, or bias, but we don't really know.

      That said, I'm for sure doing this. :cool:

      Steroids seem to be one of the few things that are "tried and true" (I felt some immediate relief after starting oral prednisone), and directly flooding the affected area makes sense to me in order to squeeze out every drop of potential benefit. Or at least as I understand the risks, the potential rewards seem to outweigh them.
       
    23. Shaqz

      Shaqz Member

      Tinnitus Since:
      12/10/19
      Cause of Tinnitus:
      Acoustic Trauma
      @Jack V how long have you had tinnitus?
       
    24. Jack V

      Jack V Member Benefactor

      Tinnitus Since:
      1/2020
      Cause of Tinnitus:
      Something Wicked This Way Comes
      A little over a month.
       

Share This Page

Loading...