MicroTransponder: Latest News and Research

Discussion in 'Research News' started by erik, Jul 3, 2012.

    1. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Moss, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma and or benzo withdrawal
      Do you know the name of the clinic? Thanx!
       
    2. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      • Helpful Helpful x 2
    3. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Moss, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma and or benzo withdrawal
    4. parsky

      parsky Member

      Tinnitus Since:
      8/1/17
      Cause of Tinnitus:
      Unknown
    5. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      An article released today. I think it is from the team of Microtransponder - University of Texas (Vanneste, Kilgard...):

      Pairing sound with vagus nerve stimulation modulates cortical synchrony and phase coherence in tinnitus: An exploratory retrospective study

      Abstract


      Recent research has shown that vagus nerve stimulation (VNS) paired with tones or with rehabilitative training can help patients to achieve reductions in tinnitus perception or to expedite motor rehabilitation after suffering an ischemic stroke. The rationale behind this treatment is that VNS paired with experience can drive neural plasticity in a controlled and therapeutic direction. Since previous studies observed that gamma activity in the auditory cortex is correlated with tinnitus loudness, we assessed resting-state source-localized EEG before and after one to three months of VNS-tone pairing in chronic tinnitus patients. VNS-tone pairing reduced gamma band activity in left auditory cortex. VNS-tone pairing also reduced the phase coherence between the auditory cortex and areas associated with tinnitus distress, including the cingulate cortex. These results support the hypothesis that VNS-tone pairing can direct therapeutic neural plasticity. Targeted plasticity therapy might also be adapted to treat other conditions characterized by hypersynchronous neural activity.

      Full text : https://www.nature.com/articles/s41598-017-17750-y
       
      • Optimistic Optimistic x 1
    6. MikeEd

      MikeEd Member

      Tinnitus Since:
      8/2018
      Cause of Tinnitus:
      Unkown
      There are ways to stimulate the Vagus nerve naturally through breathing. I just ordered some books on it and also some books on getting more oxygen into the body. I think you are better off trying to make your body as healthy as possible instead of relying on these devises.

      If you stimulate the Vagus nerve naturally you would be taking in more oxygen. Oxygen is needed for the brain to be healthy and to heal itself. When the people in this study have the Vagus nerve stimulated by an electric impulse it is absent of deep breathing. So they are not increasing the amount of oxygen going into the brain. They might be on the right track but missing the key ingredient of oxygen.

      There isn't a way for someone to make a lot of money off oxygen if you can increase the amount you are getting yourself. That's why you need to take responsibility for your own health.
       
      • Helpful Helpful x 1
    7. Stakovic

      Stakovic Member

      Tinnitus Since:
      1998
      Cause of Tinnitus:
      Unknown
      In wich university did you learn that ?
       
      • Funny Funny x 1
    8. Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
    9. NatureHiker
      Angelic

      NatureHiker Member

      It's true and not in a folk science "use these crystals to balance your aura" kind of way.

      My family doctor talked to me about it. Basically it's just breathing exercises.
       
    10. Shambles

      Shambles Member

      Tinnitus Since:
      Jan 2012
      • Agree Agree x 2
    11. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
    12. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      'Both vagus and trigeminal nerve stimulation seem to be able to suppress tinnitus, however show a different long-term effect. These results offer concrete evidence that cranial nerve stimulation paired with tones can direct therapeutic neural plasticity.'

      Whilst it's highly invasive surgically, Microtransponder's research lends a little more weight to the prospects of neuromodulation as a potentially effective treatment for tinnitus.

      As with Neuromod, Susan Shore and University of Minnesota, stimulation of certain nerves paired with tones, definitely impacts on tinnitus and neural plasticity to varying degrees in some individuals. Not sure if timings are as crucial in Microtransponder's method however. More reasons to be hopeful!
       
      • Like Like x 2
    13. Bam

      Bam Member Benefactor Hall of Fame

      Tinnitus Since:
      10/2017
      Cause of Tinnitus:
      Neck/stress
      • Good Question Good Question x 1
    14. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      Vagus nerve stimulation paired with tones for tinnitus suppression: Effects on voice and hearing

      Objective: In individuals with chronic tinnitus, our interest was to determine whether daily low-level electrical stimulation of the vagus nerve paired with tones (paired-VNSt) for tinnitus suppression had any adverse effects on motor-speech production and physiological acoustics of sustained vowels. Similarly, we were also interested in evaluating for changes in pure-tone thresholds, word-recognition performance, and minimum-masking levels. Both voice and hearing functions were measured repeatedly over a period of 1 year.

      Study design: Longitudinal with repeated-measures.

      Methods: Digitized samples of sustained frontal, midline, and back vowels (/e/, /o/, /ah/) were analyzed with computer software to quantify the degree of jitter, shimmer, and harmonic-to-noise ratio contained in these waveforms. Pure-tone thresholds, monosyllabic word-recognition performance, and MMLs were also evaluated for VNS alterations. Linear-regression analysis was the benchmark statistic used to document change over time in voice and hearing status from a baseline condition.

      Results: Most of the regression functions for the vocal samples and audiometric variables had slope values that were not significantly different from zero. Four of the nine vocal functions showed a significant improvement over time, whereas three of the pure tone regression functions at 2-4 kHz showed some degree of decline; all changes observed were for the left ear, all were at adjacent frequencies, and all were ipsilateral to the side of VNS. However, mean pure-tone threshold changes did not exceed 4.29 dB from baseline and therefore, would not be considered clinically significant. In some individuals, larger threshold shifts were observed. No significant regression/slope effects were observed for word-recognition or MMLs.

      Conclusion: Quantitative voice analysis and assessment of audiometric variables showed minimal if any evidence of adverse effects using paired-VNSt over a treatment period of 1 year. Therefore, we conclude that paired-VNSt is a safe tool for tinnitus abatement in humans without significant side effects.

      Level of evidence: Level IV.

      KEYWORDS epilepsy, hearing-threshold levels, linear-regression analysis, tinnitus, vagus-nerve stimulation, voice
       

      Attached Files:

    15. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      Safe? Great, but does it help? That's the question.
       
      • Good Question Good Question x 2
    16. Fightthearmy

      Fightthearmy Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      work-related
      Seriously, they used all this time just to tell us that? Sad.
       

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