Otonomy OTO-313 — Treatment of Tinnitus

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
      -
      Cause of Tinnitus:
      -
      Must have been horrible. I've got cataract surgery next year. Hope to hell I'm not getting any injections in the eye.
       
      • Like Like x 1
    2. Selah1281

      Selah1281 Member Benefactor

      Location:
      Bustown, OH10
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Unknown
      @ChrisBoyMonkey

      Did they ask you to sign a medical release to get access to your records from your ENT?
       
    3. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      US
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Noise
      Yeah
       
    4. Hayls32

      Hayls32 Member

      Location:
      London
      Tinnitus Since:
      1997
      Cause of Tinnitus:
      Pulsatle to begin with. Noise exposure later in life
      I've had 3 injections in one eye, these days they don't come at you like that - thankfully :confused:
       
      • Like Like x 1
    5. all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
      -
      Cause of Tinnitus:
      -
      Three times! Good to hear things have changed.
       
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    6. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      US
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Noise
      I wanted to update on this. Since getting this shot, my tinnitus has been much worse. I seriously regret getting it. It spread to my other ear just as bad, maybe even worse than my right, and it's louder in both.

      I still don't know if I got the real thing or not, but all the worsening started right after I got the shot. In fact I felt I was slowly getting better before it. Not anymore. I don't talk about it much, but I was hurting hard before I got it. Now I'm hurting even worse. Don't try this drug. I'm hoping this is temporary and will report of if it is, but its been a month of only getting worse since.
       
      • Hug Hug x 14
    7. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      This is tragic. I am so sorry to have read this. I honestly didn't expect to see a worsening. Sorry if you already said it but did you get both ears injected?
       
    8. MRItechssuck
      Disappointed

      MRItechssuck Member

      Location:
      USA
      Tinnitus Since:
      Mild 2000-2018 sev 10/17/2019
      Cause of Tinnitus:
      Loud noise, MRI
      I’m sorry to hear this as well... the only study I have heard back from showing any bit of interest was this drug.

      Thank you for the update.
       
    9. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      I had cataract surgery last September. No shots at all, just lots of Valium and numbing drops in the eye. The surgery and recovery is a breeze, you have nothing to fear:)
       
      • Informative Informative x 1
    10. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      US
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Noise
      Just the right but only about two days after the shot I started getting it on the left too. It's just bad as on the right now, and the right side also louder than before. I now have to keep my wind chimes sounds playing on spotify playing all day. Sleep has been worse too.

      I didn't expect it either since they kept telling me they had already tested on a safety group with no worsenings, but I still had a bad feeling about it. I remember the morning of they should've listened to my instincts.
       
      • Hug Hug x 2
    11. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      Praying for you man. You’ve got too good a heart for this to have happened...
       
      • Friendly Friendly x 2
    12. Selah1281

      Selah1281 Member Benefactor

      Location:
      Bustown, OH10
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Unknown
      Very sorry to hear about this. Can’t imagine dealing with that.

      Thank you for the update. I don’t think I will follow up with my appointment anymore after reading this.
       
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    13. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      Dude I’m so sorry...there’s still a very strong chance it will die back down. Please hang in there.
       
      • Like Like x 1
      • Optimistic Optimistic x 1
    14. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Sorry buddy. Give it time. You very well may have gotten the placebo. I believe our ears are hyper sensitive in these states, and that yours will again calm down with time.
       
    15. all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
      -
      Cause of Tinnitus:
      -
      This is tragic!! So sorry to hear this Chris.

      When do they tell you if you got the real thing or not? And what did they say about your tinnitus worsening?

      If it was simply from being injected in the ear then it really doesn't bode well for other drugs being researched out there. Makes me feel we are way off 5-10 years for a cure or good treatment.
       
      • Like Like x 1
    16. all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
      -
      Cause of Tinnitus:
      -
      Things could turn out very different for you.

      We just don't know though!!!
       
    17. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      So I took a look back at some of the old AM-101 threads. They were trialing kezyline, a similar (but less potent) NMDA antagonist to gacyclidine.

      Not only did the trial fail it looks like several people experiencing a worsening of their T. I wonder if Otonomy was aware of this before chasing after another NMDA antagonist.
       
      • Good Question Good Question x 2
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    18. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      You're very bad ass for going through this. You have put major skin in the game. Very brave.
       
      • Friendly Friendly x 1
    19. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      US
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Noise
      I don't know if they will at all. On Monday I'm going back, and I'm going to try to get it out of them because I need to know. I'm pretty sure I got the real thing and it's poison for us though.

      I've got my Lenire appointment next month, so hopefully that will help...
       
      • Hug Hug x 1
    20. all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
      -
      Cause of Tinnitus:
      -
      Beat it out of them!! You do need to know!! We all need to know!!

      Good luck with Lenire. I'm looking to that too... for better or worse!!
       
      • Like Like x 2
    21. patorjk

      patorjk Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Several reasons
      About a decade ago I was part of a trial for a cholesterol drug. My cholesterol dropped so low that they were required to "unblind" me from the study and tell me what group I was part of (I was part of the new drug + Lipitor group). Strangely I was allowed to stay in the study (I did it mostly because I had high cholesterol at the time and they were paying me ~$100 each time I came into the office). There are rules in place that if you're having certain kinds of reactions they're required to unblind you. I would tell them your reaction and ask about unblinding at your next appointment.
       
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    22. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      • Like Like x 1
    23. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      US
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Noise
      Not much better than the day before. In fact I was feeling suicidal to some extent earlier to be honest. I'm hoping it'll die down but I don't know.

      I'm really hoping Neuromod can help. The good reviews give me some hope. Thanks for asking.
       
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    24. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Dude, go take a bunch of NAC and curcumin. It may help you bounce back faster.
       
      • Like Like x 2
    25. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      US
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Noise
      I have been. No effect so far, it never did much for me before either.
       
      • Informative Informative x 1
    26. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Sorry, that's honestly my best advice.
       
      • Like Like x 1
    27. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      I'm sorry man. For what it's worth the thought still crosses my mind regularly and I'm 6 months in, going on 7. I truly believe that that fluid injected in there is just exacerbating your sensitive inner ear - making it act up. I believe it'll fade as that dissipates and calms down. Will likely be a few weeks. Hang tough and remember that. Work on self soothing through food, hot bath, busy projects, hikes in nature. Get out of the quiet room and work at finding peace. So much easier said than done but you'll come through.
       
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    28. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      trauma
      When you go for your appointment with Neuromod are you going to disclose that you are on this trial?
       
      • Good Question Good Question x 1
    29. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I had about 100 injections of various stuff injected into my eardrums and there was never an exacerbation of my symptoms. Only improvements.
       
      • Like Like x 1
    30. LostOutWest
      Not amused

      LostOutWest Member Benefactor

      Tinnitus Since:
      09/2019
      Cause of Tinnitus:
      Unknown
      @ChrisBoyMonkey you were straight up gangster brave for the good of everyone to be part of this trial and I am totally gutted that you're experiencing this worsening. A month is not a long time whatsoever, and I believe you can and will improve naturally. You're super positive on here and you deserved a better outcome, but you'll get there despite this setback.

      If you're anywhere near the Bay Area and want to hang, DM me. We can be miserable together.
       
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