Otonomy OTO-313 — Treatment of Tinnitus

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. all to gain

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      dirty drugs
      I never read whole threads or even go back lots of posts. I would never not be on this site if I did.

      Bad luck on the interview. Some would just have lied and said they have it in only one ear. And to be honest I wouldn't blame them.
       
    2. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      They didn't even tell me it was a disqualifier. They just asked and I answered. That was that.
       
    3. vttbx

      vttbx Member Benefactor

      Tinnitus Since:
      01/2001
      I just confirmed that they will not offer the drug if you get the placebo. 50/50.
       
    4. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      I got my injection very recently. I don't know if it was the real drug or placebo.

      My tinnitus seemed to have been healing on its own, but very slowly, so given that I haven't seen any real difference yet, I'll update the thread if I see any noticeable changes.
       
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    5. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Thank you CBM.
      Glad to hear your are healing...
       
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    6. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Thank you Daniel. I really thought my healing had stopped a while ago but I noticed it has actually been easier to mask lately than it was before. Both out and about and at home with my sound machine.

      Having said that, if I got the real thing, I would know because I didn't really notice my own natural improvements were continuing until recently, so it's very gradual. I'm sure the drug would work a bit faster than my "over the months" type of improvement if I actually got the real thing, assuming it works.
       
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    7. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      You experience changes that are tangible but slow.... this is good man. Slow and steady wins the race. Make sure you always have some foam plugs on you for unexpected noise.

      As far as the drug goes... you're just going to have to wait and see? Who knows man, this is all so new. Wait and see. Regardless you've helped push science forward and we are all grateful for that.

      Keep us posted buddy and keep healing up... you're doing great.
       
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    8. vttbx

      vttbx Member Benefactor

      Tinnitus Since:
      01/2001
      Best of luck. I hope it helps. How painful was the injection?
       
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    9. MRItechssuck

      MRItechssuck Member

      Location:
      USA
      Tinnitus Since:
      2002-2015, 10/17/2019-?
      Cause of Tinnitus:
      Loud noise, MRI
      Whoops... I told the truth... both ears... and I haven’t heard back either.

      NCT03918109, 313-201901, OTO-313 in Subjects With Subjective Tinnitus
       
    10. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      I appreciate it. The shot didn't hurt too bad, what bothered me more was when they were spreading a numbing cream in my ear. That part was more painful than the shot, apparently they have to get it in some hard to reach spot.

      I've been having some ear pain since the shot, which they said would be normal, and it's nothing I can't handle. It's not that bad. They also said headaches would be common too but I don't have that at all.
       
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    11. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      So is it just 1 shot or do you need another one soon?

      When will they let you know if you received placebo or the real drug?

      I know you haven’t noticed any difference with your tinnitus other than it being easier to mask. Do you notice any reduction of your hyperacusis?
       
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    12. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Easier to mask has been from natural slwoly over time healing. The shot so far has not had any noticeable effect. It is only one shot, so I'll only be going back for assessments from here on.

      I don't really have hyperacusis, but the drug isn't intended for that anyways.

      They should be telling me what I got injected at the end of my following, so about 8 weeks.
       
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    13. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I'm on the edge of my seat.
       
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    14. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      well wth. @ChrisBoyMonkey can just talk to us about what he is experiencing. Why can't we get info on the Audion and Frequency Therapeutics trial participants?
       
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    15. GSC
      Wishful

      GSC Member Hall of Fame

      Tinnitus Since:
      02/2019
      Cause of Tinnitus:
      Acoustic trauma.
      Amazing. Someone from here is getting this drug and is in the trial?! Please don't disappear and keep us noted!
       
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    16. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Don't worry, I'm here lol
       
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    17. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      How'd you like getting that needle in your ear? Fun right? Did you get vertigo for a few minutes?
       
    18. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Tons of fun. I didn't get any vertigo, but the last few days I've been noticing some bad ear pain that comes and goes, probably just because of the eardrum healing.
       
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    19. Selah1281

      Selah1281 Member Benefactor

      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Unknown
      Great, where I had surgery on that ear and it’s still healing the last thing I want is more pain. Even if mine is a month away.
       
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    20. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      ew. yeah hope that goes away.
       
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    21. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Well it's not too bad, specifically last night I had some moments of bad pain but they only lasted for like maybe 30 seconds.

      Today I haven't really felt the pain so far, maybe a mild bit. Keep in mind it's only been a few days since the injection.
       
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    22. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Now that I think about it, I had some pain in my ears that lasted only a few seconds each time for a few weeks after all of my injections. Is that like yours? Very brief sharp pains?
       
    23. vttbx

      vttbx Member Benefactor

      Tinnitus Since:
      01/2001
      Are there any restrictions to stay in quiet environments while the eardrum heals?
       
      • Good Question Good Question x 1
    24. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Exactly like that. I haven't felt it today though.
       
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    25. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      No, I just can't allow anything to get in my ear, not even water.
       
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    26. all to gain

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      dirty drugs
      I remember my Dad saying that 50 years ago he got a thorn in his eye. He had to have an injection in his eye. Imagine watching a needle coming down towards your eye and then piercing it. Fuck that.
       
    27. all to gain

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      dirty drugs
      I really hope you got the real stuff and not the placebo. We need information that this stuff works... we need hope!!
       
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    28. HootOwl

      HootOwl Member Benefactor

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
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    29. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      They didn't say actually, but I think they will. I'll ask to make sure though.
       
    30. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      When I got LASIK they asked if I wanted plugs too. They didn't tell me how they would get them in there and I must said yes since I heard they were helpful.

      The way they got them in was exactly that, and the doctor actually messed up in one eye so she kept stabbing around with the needle in there for a little bit until she eventually just pulled it out and tried it again.
       

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