Pimozide for COVID-19 Induced Tinnitus — Jupiter Wellness

[InNeedOfHelp]

Pimozide: Treatment for Post Acute COVID-19 Syndrome

A new clinical trial will start. I'm not sure what the difference in pathology between COVID-19 tinnitus and other tinnitus is.

There is some hypothesis published earlier that dopamine modulators can influence tinnitus.

Tinnitus dopaminergic pathway. Ear noises treatment by dopamine modulation

Any thoughts?

 

[Stayinghopeful]

I'm curious if anyone knows why they are looking at Pimozide in particular for COVID-19 induced tinnitus?

 

[Guywithapug]

I've never come across Jupiter Wellness before, nor have I seen anything discussed about it on Tinnitus Talk. According to the article, they discuss potentially treating COVID-19 induced tinnitus, but also subjective tinnitus, with dopamine receptor modulation.

"During the COVID-19 pandemic, Jupiter Wellness scientists discovered a novel pathway for the treatment of COVID-19 induced tinnitus and possibly subjective tinnitus. The discovery led to a patent recently filed by Jupiter Wellness for the use of dopamine receptor modulation for the treatment of tinnitus.

The Company has just launched a study to investigate if dopamine receptor modulation can be used effectively to treat COVID-19 induced tinnitus."

Jupiter Wellness Initiates Clinical Trial for Potential New Treatment for Tinnitus

 

[Damocles]

I want to hear from @Jupiterman on this.

 

[Guywithapug]

I want to hear from @Jupiterman on this.

Am I not good enough for you @Damocles? Nobody's good enough, are they? Except Jupiterman...

 

[Damocles]

Am I not good enough for you @Damocles? Nobody's good enough, are they? Except Jupiterman...

Ah man, it's nothing personal. Just, this is Jupiter Wellness we're talking about here, and you're not a Jupiter man.

Heck, you're not even a Planet man, let's face it.

Trust, if there are ever any rumours about a Tinnitus treatment over at Pug Wellness, it's you I'm going to want to hear from, baby.

 

[Nick47]

Just looking at this again.

Pimozide is a medication that's available and on the market, so why have they filled a patent?

Also, I'm guessing if this is successful, it could be approved as it's already on the market.

Leads me to wonder why anyone really struggling hasn't given it a try, IF they can get it prescribed.

 

[Hottopic29]

Just looking at this again.

Pimozide is a medication that's available and on the market, so why have they filled a patent?

Also, I'm guessing if this is successful, it could be approved as it's already on the market.

Leads me to wonder why anyone really struggling hasn't given it a try, IF they can get it prescribed.

Yea, I might try Pimozide.

 

[Nick47]

Yea, I might try Pimozide.

It's worth a go for a couple of weeks. We won't know unless we try. Aside from dopamine, I noticed it's an extremely potent 5-HT7 antagonist (which lie in the DCN) and read it is also an H4 antagonist, which recently is implicated in tinnitus.

The problem will be getting it prescribed.

 

[lapidus]

Just looking at this again.

Pimozide is a medication that's available and on the market, so why have they filled a patent?

Also, I'm guessing if this is successful, it could be approved as it's already on the market.

Leads me to wonder why anyone really struggling hasn't given it a try, IF they can get it prescribed.

Pimozide is not on the market here in Sweden. The last form of it (Orap 2 mg) was taken off the market in 2001. I can't find any information on why it was taken from the Swedish market though.

 

[Mentos]

Does anyone know how to check in which countries Pimozide is available?

 

[lymebite]

The problem will be getting it prescribed.

In the US pretty much any medication can be prescribed off-label, so no issue in that particular country.

Wikipedia says Pimozide was approved in 1985 in the US. That's a long time ago. I wonder if any anecdotes exist of it lowering the volume of tinnitus.

 

[Nick47]

Does anyone know how to check in which countries Pimozide is available?

@Mentos, no. But I did spend 5 minutes looking at this for you. On Wikipedia it says it's available in the USA and Australia (unless you can import it with a valid prescription). Are you thinking of subbing out the Flupentixol for a few weeks and replacing with Pimozide?

 

[awake 44]

@Mentos, no. But I did spend 5 minutes looking at this for you. On Wikipedia it says it's available in the USA and Australia (unless you can import it with a valid prescription). Are you thinking of subbing out the Flupentixol for a few weeks and replacing with Pimozide?

There is an easy way to import this drug to Poland via our Ministry of Health. I think they import it from Belgium.

 

[Mentos]

@Mentos, no. But I did spend 5 minutes looking at this for you. On Wikipedia it says it's available in the USA and Australia (unless you can import it with a valid prescription). Are you thinking of subbing out the Flupentixol for a few weeks and replacing with Pimozide?

I exchanged a short message with my shrink who sees no counter indication to try Pimozide and is willing to help with a procedure to import it. I will still need to discuss with him the details whether to suspend Flupentixol or Doxepin while on Pimozide or to take it on top. Obviously I don't want to lose from what I achieved so far (reduction of my tinnitus to level 1-4 depending on a day) which is absolutely livable. Still, since I noticed playing with my brain chemistry and bioelectrical activity via drugs, tDCS and Will Sedley sound therapy bear fruit, I keep exploring further.

 

[Nick47]

I exchanged a short message with my shrink who sees no counter indication to try Pimozide and is willing to help with a procedure to import it. I will still need to discuss with him the details whether to suspend Flupentixol or Doxepin while on Pimozide or to take it on top. Obviously I don't want to lose from what I achieved so far (reduction of my tinnitus to level 1-4 depending on a day) which is absolutely livable. Still, since I noticed playing with my brain chemistry and bioelectrical activity via drugs, tDCS and Will Sedley sound therapy bear fruit, I keep exploring further.

@Mentos, I agree fully. It seems it's the combination that is effective rather than the individual parts. Once I stopped looking at does this work, does that work, and realised it's the sum of all parts, it opened up new avenues.

I don't think the Pimozide will affect Doxepin but may overload the dopamine receptors with Flupentixol added.

We need a thread that says 'cocktails'.

Besides they are usually nicer by the pool in the summer than a beer

 

[Fightthearmy]

We need a thread that says 'cocktails'.

Sure, but what about methodology? How does one interpret the observations? There should be from the onset a stress on a top-down approach: from the rule to the exception; from what is known (about the interaction of these drugs) to what is unknown.

 

[Nick47]

Sure, but what about methodology? How does one interpret the observations

@Fightthearmy, I suppose in the same way as an individual therapy. Same or similar trial design. But it would be better with tinnitus 'subgroups' etc. Placebo? Mono therapy or crossover design?

 

[momus]

Pimozide is a medication that's available and on the market, so why have they filled a patent?

That's a good question. I looked at the costs for filing a patent application and they're considerable. It appears to be $6000+ because you really need a patent attorney to make sure it will stand up. But patent attorneys also say there is a low cost way to this by filing something called a Provisional Patent. At some point that would need to be upgraded to a regular patent application, but this gets your idea in the front door and only costs $150 to $300. The Provisional Patent lasts one year.

 

[El BUZZ]

I might put my hands on Pimozide since it is commercialized here in Spain and I have a contact who can prescribe it to me. I'm in that point in which I'm willing to try anything.

 

[Nick47]

I might put my hands on Pimozide since it is commercialized here in Spain and I have a contact who can prescribe it to me. I'm in that point in which I'm willing to try anything.

If it helps, the clinical trial is using 1 mg a day. Let us know.

 

[Nick47]

Hi @Mentos, did you ever start to trial Pimozide? I think the trial concludes in 6 weeks. A solid enough study (triple blinded, moderate size group and placebo controlled) so if results show a big difference over placebo, it's worth looking at. I noticed the stock has increased almost 50% in the last month, though I'm not an investor.

 

[Mentos]

Hi @Mentos, did you ever start to trial Pimozide? I think the trial concludes in 6 weeks. A solid enough study (triple blinded, moderate size group and placebo controlled) so if results show a big difference over placebo, it's worth looking at. I noticed the stock has increased almost 50% in the last month, though I'm not an investor.

So far, I've only increased my Flupentixol dosage to 2 mg and have had 8 Cerebrolysin injections. The latter seems to be yielding good results, as my tinnitus has been at a 1-2/10 level over the past week.

 

[Nick47]

So far, I've only increased my Flupentixol dosage to 2 mg and have had eight Cerebrolysin injections. The latter seems to be yielding good results, as my tinnitus has been at a 1-2/10 level over the past week.

Wow, that's interesting. Thanks for sharing with the community.

That's a big jump from 0.5 mg to 2 mg. Do you get any side effects? It worried me how Dr. De Ridder said I must take Clonazepam with just one Deanxit to prevent tardive dyskinesia.

 

[JRC1]

So far, I've only increased my Flupentixol dosage to 2 mg and have had eight Cerebrolysin injections. The latter seems to be yielding good results, as my tinnitus has been at a 1-2/10 level over the past week.

i am glad that you have had improvement. How would you rate your tinnitus before this treatment? Do you have hyperacusis?

 

[Mentos]

i am glad that you have had improvement. How would you rate your tinnitus before this treatment? Do you have hyperacusis?

No hyperacusis for me. My tinnitus was 2-4 before the treatment, for the last 2 weeks it is a consistent 2, at times even a 1.

 

[ErikaS]

No hyperacusis for me. My tinnitus was 2-4 before the treatment, for the last 2 weeks it is a consistent 2, at times even a 1.

You said you had had 8 injections, do you get a number of them per week? Where specifically are the injections done on the body and are they done by a neurologist?

 

[Mentos]

You said you had had 8 injections, do you get a number of them per week? Where specifically are the injections done on the body and are they done by a neurologist?

The package I paid is 10 injections, these were forearm intravenous injections. Prescribed by neurologist but conducted by nurse. It took me 2 weeks to finish all 10.

 

[Nick47]

I expect Jupiter Wellness have many other things in the pipeline, however their tinnitus trial wrapped up in June. Their stock has gone through the roof!

 

[Utdmad89]

I expect Jupiter Wellness have many other things in the pipeline, however their tinnitus trial wrapped up in June. Their stock has gone through the roof!

Is that a good sign on the tinnitus front?