Pipeline Therapeutics

Discussion in 'Research News' started by FGG, Nov 14, 2019.

    1. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      Would treatment with this product limit the effectiveness the future use of Frequency's FX-322 product. Aka does the increase in ATOH expression use up supporting cells?
       
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    2. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
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      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I believe so.
       
    3. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      That's the answer I was afraid of.
       
    4. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
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      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      FX-322 is formulated to divide supporting cells so this doesn't occur.
       
    5. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      Right but is PIPE-505 dividing the supporting cells?
       
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    6. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
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      Aspirin Toxicity/Possibly Noise
      I don't think they have revealed that information.
       
    7. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      This was what was shared with me via email regarding the question of whether or not PIPE-505 depletes supporting cells when generating OHC.

      “The current hypothesis is that 505 transforms LGR5+ supporting cells. This constitutes a small population of support cells in the adult cochlea so we do not observe widespread depletion of all support cells.”
       
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    8. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
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      Cause of Tinnitus:
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      COOL
       
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    9. John Queen

      John Queen Member

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown
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    10. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      I think Audion Regain are also on track to release their Phase 2 results in April 2020 as far as I can recall!
       
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    11. John Queen

      John Queen Member

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown
      Yes, that's correct. At least, that's what should happen; initially they announced the results will be published on 31/01/2020, but changed that recently, maybe something interesting happened and they need more time to analyze the data.
       
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    12. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
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      Tinnitus Since:
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      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Yeah, like it cured tinnitus.
       
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    13. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      US
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Noise
      PLEASE THIS.
       
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    14. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
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      Cause of Tinnitus:
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      We have an alleged anecdote from someone in this trial stating it did in fact help their tinnitus and hyperacusis. Fingers crossed.
       
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    15. Nonomat
      Wishful

      Nonomat Member Benefactor

      Location:
      France
      Tinnitus Since:
      06/2019 (mild) - 11/2019 (intrusive)
      Cause of Tinnitus:
      Noise induced
      Sorry, sometimes keeping track of everything here is hard. Which trial are you referring to? Audion/Regain?
       
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    16. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
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      Cause of Tinnitus:
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      Yeah. That one.
       
    17. Nonomat
      Wishful

      Nonomat Member Benefactor

      Location:
      France
      Tinnitus Since:
      06/2019 (mild) - 11/2019 (intrusive)
      Cause of Tinnitus:
      Noise induced
      Wow that's amazing. Thank you!
       
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    18. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
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    19. F-u-T

      F-u-T Member Podcast Patron Benefactor

      Location:
      AZ USA
      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Acoustic Trama
      Would trade my left nut for this to improve my T and H.
       
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    20. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
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      Cause of Tinnitus:
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      I'd trade all 3 of mine.
       
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    21. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
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      Cause of Tinnitus:
      Acoustic trauma
      How do they even enroll participants in this study? “Come to the clinic, we’ll see if you can’t hear shit when other shit’s going on.” What’s the test for hidden hearing loss?

      I’m about to call and ask if this is their only recruiting location. If it is, you’re not too far from there are you @HootOwl ?

      10578 Science Center Drive Ste. 200, San Diego, CA 92121
       
    22. AUTHOR
      AUTHOR
      FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
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      They don't recruit at their headquarters. Trials are done at impartial trial centers. To give you an idea, Hough (located in OKC, OK) is a full otology clinic and their study was done in Raleigh, NC apparently. And phase 1 of Frequency was done in San Antonio, TX.
       
    23. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      I reached out to them about trial locations so hopefully they get back to me, so I can post them here for people interested.
       
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    24. Ben S
      Curious

      Ben S Member

      Location:
      Connecticut
      Tinnitus Since:
      11/2015
      I'm really hoping that I can get in this trial...any word yet @mrbrightside614 on trial locations? I am positive that I have synaptopathy, and treatments like these are the only thing I look forward to these days.
       
    25. AUTHOR
      AUTHOR
      FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Phase 1 is often at 1 location (2 at the most usually). Phase 2 is where nationwide testing occurs.

      FX-322 phase 1 was in San Antonio, TX and Hough phase 1 was in Durham, NC, etc. Be prepared to travel in most cases.
       
    26. AUTHOR
      AUTHOR
      FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
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    27. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      Nada. Regardless, it’d be the longest shot ever to get admitted to a trial whose primary indications aren’t explicitly for tinnitus. Sorry bro. If we don’t have people getting into FX-322 I really doubt we’re going to have anyone getting into cochlear synaptopathy trials.
       
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    28. Tweedleman
      Depressed

      Tweedleman Member Benefactor

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown/Noise
      I hear you. I've never wanted needles in my eardrum so much as I do now.
       
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    29. AUTHOR
      AUTHOR
      FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I would hope though that Pipeline wouldn't exclude tinnitus patients since it is literally in their patent but I'm pretty sure you would need some record of having (testable) Speech in Noise difficulties, though and there are definitely people on this forum who do even if many don't.
       
    30. Ben S
      Curious

      Ben S Member

      Location:
      Connecticut
      Tinnitus Since:
      11/2015
      Yes, I am in New England, but I have to put this on hold for now because I don't want to risk losing this newly acquired job. Also, not being able to get the real thing after potentially getting a placebo is a SERIOUS downer. 6 days of paid time off, and about 20 hours of total drive time (for all the visits) for nothing.... that would be awful. Although knowing that my potential cure is out there but I don't have it is borderline torture. So a part of me still wants to go for it though because I am in such a dark place.
       

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