Prof. Thanos Tzounopoulos Receives $2 Million Grant

Discussion in 'Research News' started by Jack Straw, Dec 4, 2018.

    1. Jack Straw
      Balanced

      Jack Straw Member Benefactor Ambassador Hall of Fame

      Location:
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      Tinnitus Since:
      1990s
      Cause of Tinnitus:
      Infection, Acoustic Trauma
      https://inside.upmc.com/pitt-researchers-grant-tinnitus/

      Seems like he is investigating something similar epilepsy drugs.

      I remember reading a thread where @Danny Boy said his tinnitus was practically gone after taking epilepsy drugs. I also remember from that thread that Dannyboy mentioned that he was having visual snow problems and in the article they even mention that epilepsy drugs have a side effect of making changes to the retina.

      Anyone know more about this research?
       
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    2. EDDTEKK

      EDDTEKK Member

      Location:
      Europe
      Tinnitus Since:
      2000
      Cause of Tinnitus:
      Noise Exposure
      Wow that are great news. Hope they will find a way to defeat tinnitus by this medication.
      I only know carbamazepine which was working for my intermittent tinnitus pretty good. Unfortunately after 6 months it was losing its efficiency... and the tinnitus came back much worse.
       
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    3. Zeneth
      Wishful

      Zeneth Member Benefactor

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Maybe noise?
      I've developed visual snow as well.
       
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    4. Don Tinny

      Don Tinny Member

      Location:
      Argentina
      Tinnitus Since:
      2017 (worsening)
      Cause of Tinnitus:
      Loud concert with ear plugs
      I would not be surprised. I have read texts that describe tinnitus as an "auditory epilepsy". What an ugly thing!

      These drug developments of prof. Tzounopoulos, dr. Rauschecker, etc. are about 15 years away, right? I assume they are in a pre-clinical stage and they need to go through phase 1, phase 2, phase 3 ... Rauschecker said "soon", but how soon can it be?
       
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    5. AUTHOR
      AUTHOR
      Jack Straw
      Balanced

      Jack Straw Member Benefactor Ambassador Hall of Fame

      Location:
      US
      Tinnitus Since:
      1990s
      Cause of Tinnitus:
      Infection, Acoustic Trauma
      Hopefully during the interview with Rauschecker, they will be able to discuss this with him.

      15 years is too long.....
       
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    6. Zeneth
      Wishful

      Zeneth Member Benefactor

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Maybe noise?
      Didn't Trump sign a Right to Try Act a little while back? If we find out that these drugs actually work, something will have to be worked out to get it to us faster. If a drug is working NOW, 15 years is just ridiculous.
       
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    7. Striveon

      Striveon Member

      Tinnitus Since:
      08/2018
      Cause of Tinnitus:
      Unknown
      15 years?!?! That's insane!
       
    8. Don Tinny

      Don Tinny Member

      Location:
      Argentina
      Tinnitus Since:
      2017 (worsening)
      Cause of Tinnitus:
      Loud concert with ear plugs
      OK, OK...maybe 10 years?
       
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    9. Don Tinny

      Don Tinny Member

      Location:
      Argentina
      Tinnitus Since:
      2017 (worsening)
      Cause of Tinnitus:
      Loud concert with ear plugs
      If the solution is an IRSS type drug or something like that, I recommend you keep your hormones healthy. These drugs lower libido considerably and it is necessary to have good hormone levels so that they do not affect you too much. It is the advice of a person who took finasteride more than 2 years and has some damage.
       
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    10. WaqasVic
      Artistic

      WaqasVic Member

      Location:
      Pakistan
      Tinnitus Since:
      01/2013
      Cause of Tinnitus:
      My T is way different than all of you , ask me how
      Yea Danny Boy's tinnitus got very manageable by that medicine but he got the visual snow from it. I read that from his posts.
       
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    11. Striveon

      Striveon Member

      Tinnitus Since:
      08/2018
      Cause of Tinnitus:
      Unknown
      YEAH... much better... NOT, they need to hurry up, this is insane :(
       
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    12. TuxedoCat
      No Mood

      TuxedoCat Member Benefactor Ambassador

      Location:
      US
      Tinnitus Since:
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      Cause of Tinnitus:
      high frequency hearing loss
      Hi Jack, I don't think much more is known about the research than whats in the article you have. Basically, Professor Tzounopoulos and Professor Wipf at the University of Pittsburgh took Trobalt (Retigabine) and redesigned it. They called the new drug, RL-81. RL-81 is more potent and more specific than Trobalt and is thought to have fewer side effects. Trobalt was the epilepsy drug that helped Danny's tinnitus and yes, it accumulated in skin and eyes and turned blue from oxidation. Not quite Smurf blue, but some under the fingernails and colored parts of the eyes. There are pictures on Google Images. After awhile GlaxoSmithKine discontinued selling it.

      There is also a second part of the project to look at blocking a receptor called HCN which might prevent hearing loss from loud noise. The Department of Defense is funding the research so preventing hearing loss from blast explosions would be of interest to them.

      I don't know that Rauschecker would know much about it, I think he's interested in an animal model, but we'll definitely learn more from his interview. Take care- TC
       
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    13. Autumnly
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      Autumnly Member Benefactor Hall of Fame

      Tinnitus Since:
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      Towards a Mechanistic-Driven Precision Medicine Approach for Tinnitus
      Thanos Tzounopoulos, Carey Balaban, Lori Zitelli, Catherine Palmer
      First online: 01 March 2019


      Abstract
      In this position review, we propose to establish a path for replacing the empirical classification of tinnitus with a taxonomy from precision medicine. The goal of a classification system is to understand the inherent heterogeneity of individuals experiencing and suffering from tinnitus and to identify what differentiates potential subgroups. Identification of different patient subgroups with distinct audiological, psychophysical, and neurophysiological characteristics will facilitate the management of patients with tinnitus as well as the design and execution of drug development and clinical trials, which, for the most part, have not yielded conclusive results. An alternative outcome of a precision medicine approach in tinnitus would be that additional mechanistic phenotyping might not lead to the identification of distinct drivers in each individual, but instead, it might reveal that each individual may display a quantitative blend of causal factors. Therefore, a precision medicine approach towards identifying these causal factors might not lead to subtyping these patients but may instead highlight causal pathways that can be manipulated for therapeutic gain. These two outcomes are not mutually exclusive, and no matter what the final outcome is, a mechanistic-driven precision medicine approach is a win-win approach for advancing tinnitus research and treatment. Although there are several controversies and inconsistencies in the tinnitus field, which will not be discussed here, we will give a few examples, as to how the field can move forward by exploring the major neurophysiological tinnitus models, mostly by taking advantage of the common features supported by all of the models. Our position stems from the central concept that, as a field, we can and must do more to bring studies of mechanisms into the realm of neuroscience.

      You can buy this article for roughly 42 euros...
       
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    14. annV
      Fine

      annV Member

      Tinnitus Since:
      2005
      Cause of Tinnitus:
      unknown - possibly hereditary
      I got you the full text article.
       

      Attached Files:

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    15. AUTHOR
      AUTHOR
      Jack Straw
      Balanced

      Jack Straw Member Benefactor Ambassador Hall of Fame

      Location:
      US
      Tinnitus Since:
      1990s
      Cause of Tinnitus:
      Infection, Acoustic Trauma
      Can someone give me the TLDR?
       
    16. TuxedoCat
      No Mood

      TuxedoCat Member Benefactor Ambassador

      Location:
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      Tinnitus Since:
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      Cause of Tinnitus:
      high frequency hearing loss
      Thanks @Autumnly, @annV
      Can't wait to read!

      TC
       
    17. Johan_L

      Johan_L Member

      Location:
      Sweden
      Tinnitus Since:
      05/2015
      Cause of Tinnitus:
      Noise induced
      When reading this I just think of how far the scientists are from understanding tinnitus and hyperacusis.
       
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    18. Allan1967

      Allan1967 Member Benefactor

      Tinnitus Since:
      1997
      Cause of Tinnitus:
      Ear infection
      Hi.

      I donate to Thanos Tzounopoulos, PhD at the University of Pittsburg.

      I asked recently about his research and the direct response I got from Thanos was they are 'currently performing the preclinical development of two lead candidates'.

      I have an idea what that means but can anyone explain further?

      Thanks.
       
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    19. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      It means they aren't sitting around going "aaaaaddddurp" like almost everyone else. "Candidates" in this case are like drugs or something.
       
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    20. Clint Azzopardi
      Woot

      Clint Azzopardi Member

      Tinnitus Since:
      October 2018
      Cause of Tinnitus:
      Not sure, Gentamicin or allaergy or both !
      Thanks @annV for the article.
       
    21. Allan1967

      Allan1967 Member Benefactor

      Tinnitus Since:
      1997
      Cause of Tinnitus:
      Ear infection
      My interpretation is that they have two types of drugs they are working on which are at the pre-clinical trial stage which means they are still a fair way out from being tested on humans and probably even further away from being released.

      However, at least it's something.
       
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    22. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      It means some guinea pigs are having their tinnitus solved, hopefully without getting blue in the face and without visual problems.
       
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    23. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      He said he needed a million to find a cure. Well there’s 2 million, let’s do it.
       
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    24. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      here
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      Oneeternitylater.jpg
       
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    25. Allan1967

      Allan1967 Member Benefactor

      Tinnitus Since:
      1997
      Cause of Tinnitus:
      Ear infection
      It's a great time to be a guinea pig.
       
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    26. Ozlem Senturk

      Ozlem Senturk Member

      Tinnitus Since:
      2 months
      Cause of Tinnitus:
      loud noise, eustachian tube blockage
      In one of his articles named "LI S, KALAPPA BI, TZOUNOPOULOS T (2015) Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus." they mention two possible treatment ways, maybe he was referring to these 2 types of drugs:

      "now show that exposure to excessive noise causes a reduction in KCNQ2/3 activity in the exposed mice. However, in animals that successfully avoid developing tinnitus, KCNQ2/3 activity spontaneously recovers over the course of a few days. This recovery triggers a reduction in the activity of another type of ion channel, known as the HCN channel. The combined flexibility of KCNQ and HCN channels prevents tinnitus-associated hyperactivity in the fusiform cells.

      Drugs that increase activity of KCNQ2/3 channels, and/or reduce activity of HCN channels, could thus boost resilience to tinnitus. In the future, targeting both channel types at the same time could provide an effective treatment with minimal side effects."​
       
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    27. smapti

      smapti Member

      Tinnitus Since:
      07/1991
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      Ear Infections
      Thought I would chime in on this one and show you a reply to a recent e-mail from Dr.
      Tzounopoulos. As far as I see it, he is our greatest hope. Everything else is just so...well...1972.

      Hello -

      I know you get a lot of questions about this, so I'll be brief:

      (1) Will RL-81 have a clinical trial? If so, when will it start?

      Yes. We are currently performing preclinical studies (toxicity, etc)


      (2) What is the possibility it will work for tinnitus sufferers?

      Do not know for sure, but I am optimistic based on our research so far


      (3) If it works, when do you project it could be on the market? 5 years? 10 years? Not in our lifetime?

      Hard to predict the future – I do not plan to leave the planet before we have FDA approved medication for tinnitus
       
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    28. Hayls32

      Hayls32 Member

      Location:
      London
      Tinnitus Since:
      1997
      Cause of Tinnitus:
      Pulsatle to begin with. Noise exposure later in life
      He might live to 90! :p Here is hoping for something in the next few years :)
       
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    29. DaveFromChicago

      DaveFromChicago Member

      Tinnitus Since:
      01/2014
      Cause of Tinnitus:
      Headcold/Flu
      I have lately been considering the similarities between the history of treatments for migraines versus those for tinnitus.

      Before the release of the drug Maxalt, there were as many initially promising but utterly ineffective "therapies" for migraines as there now are for tinnitus.
      I have migraines, and nothing actually fully reached and dissolved the pain before the development of amitriptyline (Maxalt).

      I fervently hope that Lenire yields real effectiveness, but I have always intuitively felt that the ultimate solution will reside in drug innovations.
       
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    30. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      It's good that he specifies tinnitus in his research aims. I recall his interest in modifying drugs like Trobalt, was to treat epilepsy, with tinnitus as a happy side benefit.

      But at this stage this looks like it's a decade away. I like to think we will have other options before then.
       
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