Street Novelist
Member
- Apr 2, 2018
- 303
- Tinnitus Since
- February 2018
- Cause of Tinnitus
- Listening to loud music through headphones
Rinri Therapeutics
- Thread starter Nick47
- Start date
Street Novelist
Member
- Apr 2, 2018
- 303
- Tinnitus Since
- February 2018
- Cause of Tinnitus
- Listening to loud music through headphones
Oh man… it might be years before we know the results. It says the year 2027.
Yes, waiting is definitely difficult. I hope they are successful. Who knows, they might even have promising data before then. If the cochlear implants monitor the health of the ear and patients send data daily, hopefully that helps move things forward. I'm not sure myself, though.
Member- Jan 16, 2020
- 616
- Tinnitus Since
- 1992
- Cause of Tinnitus
- noise? infection? negative stress? other?
This might be a bit obscure, or it might make for good reading. Who knows? The folks at Rinri might even find it useful.
It is neat and interesting, but to be honest, I could hardly identify a cell even if it were inside a prison. So I will leave this one to the heavyweights.
Summary: Zebrafish can regenerate sensory hair cells that humans permanently lose, like those in the inner ear linked to hearing and balance. New research reveals two specific genes that control how different supporting cells in zebrafish divide and regenerate, offering clues to how mammals might someday tap into similar regenerative powers.
Striking was that the scientists don't need any x-ray or optical scanning of the cohclea:
Because zebrafish are transparent during development and have accessible sensory organ systems, scientists can visualize, as well as genetically sequence and modify, each neuromast cell. This allows them to investigate the mechanisms of stem cell renewal, the proliferation of progenitor cells -- direct precursors to hair cells -- and hair cell regeneration.
It is neat and interesting, but to be honest, I could hardly identify a cell even if it were inside a prison. So I will leave this one to the heavyweights.
Can zebrafish help humans regrow hearing cells?
Zebrafish can regenerate sensory hair cells that humans permanently lose, like those in the inner ear linked to hearing and balance. New research reveals two specific genes that control how different supporting cells in zebrafish divide and regenerate, offering clues to how mammals might someday...
sciencedaily.com
Can zebrafish help humans regrow hearing cells?
Stowers scientists identify specific genes involved in zebrafish sensory hair cell regrowth, providing new insights that could inform future research into hearing loss treatments.
Summary: Zebrafish can regenerate sensory hair cells that humans permanently lose, like those in the inner ear linked to hearing and balance. New research reveals two specific genes that control how different supporting cells in zebrafish divide and regenerate, offering clues to how mammals might someday tap into similar regenerative powers.
Striking was that the scientists don't need any x-ray or optical scanning of the cohclea:
Because zebrafish are transparent during development and have accessible sensory organ systems, scientists can visualize, as well as genetically sequence and modify, each neuromast cell. This allows them to investigate the mechanisms of stem cell renewal, the proliferation of progenitor cells -- direct precursors to hair cells -- and hair cell regeneration.
The trial has started on time!
This study aims to regenerate auditory neurons, also known as spiral ganglion neurons, in individuals with auditory neuropathy. Tinnitus Talk interviewed Professor Marcelo Rivolta back in 2019, and I believe it was one of their first podcasts. Now, six years later, the clinical trial is finally underway.
The team has strong preclinical data from animal studies in gerbils. Professor Rivolta noted at the time that using this animal model was important because gerbils have hearing systems that closely resemble those of humans.
If the results translate successfully from animals to humans, patients with profound deafness could potentially regain the ability to engage in natural human conversations.
That said, it's important to remember that there is currently no evidence of success in humans, and no previous trials have yet achieved this goal.
Clinical Trial Page
This study aims to regenerate auditory neurons, also known as spiral ganglion neurons, in individuals with auditory neuropathy. Tinnitus Talk interviewed Professor Marcelo Rivolta back in 2019, and I believe it was one of their first podcasts. Now, six years later, the clinical trial is finally underway.
The team has strong preclinical data from animal studies in gerbils. Professor Rivolta noted at the time that using this animal model was important because gerbils have hearing systems that closely resemble those of humans.
If the results translate successfully from animals to humans, patients with profound deafness could potentially regain the ability to engage in natural human conversations.
That said, it's important to remember that there is currently no evidence of success in humans, and no previous trials have yet achieved this goal.
Clinical Trial Page
That's awesome! So they have started already? I am hopeful for Rinri, and that this trial will have good results! Then we will know for sure!The trial has started on time!
This study aims to regenerate auditory neurons, also known as spiral ganglion neurons, in individuals with auditory neuropathy. Tinnitus Talk interviewed Professor Marcelo Rivolta back in 2019, and I believe it was one of their first podcasts. Now, six years later, the clinical trial is finally underway.
The team has strong preclinical data from animal studies in gerbils. Professor Rivolta noted at the time that using this animal model was important because gerbils have hearing systems that closely resemble those of humans.
If the results translate successfully from animals to humans, patients with profound deafness could potentially regain the ability to engage in natural human conversations.
That said, it's important to remember that there is currently no evidence of success in humans, and no previous trials have yet achieved this goal.
The trial is registered as "Not yet recruiting" at ClinicalTrials.gov. The estimated start was 2025-10.
A newsletter dated 2025-11-06 and signed by Douglas Hartley, Chief Medical Officer at Rinri Therapeutics, states:
Rinri Therapeutics webiste elaborates:
They're still game, but will take their sweet time.
A newsletter dated 2025-11-06 and signed by Douglas Hartley, Chief Medical Officer at Rinri Therapeutics, states:
Rinri Therapeutics webiste elaborates:
They're still game, but will take their sweet time.
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