Sensorion's New Drug: SENS-401

[nononeac]

Hi,
Sensorion Selects New Drug Candidate to Treat Vestibular and Auditory Disorders Associated with Inner Ear Lesions : SENS-401 (September 29th, 2016)

Download press release (EN)

Download press release (FR)

 

[Foncky]

This is from a French company, I'll try to get more details from them.

 

[Mario martz]

wow i didnt see that coming

this is fantastic could work to protect the ear from further damage of vestibular problems like menieres

 

[Coyotesheaven]

Ooh, finally a preventative drug for preventing long-term degradation of the inner ear (maybe)! Finally hope for some people who are developing inner ear disorders as a result of long standing acoustic trauma or other factors.

I didn't see anything specific, however, in how it is supposed to combat hearing loss, T, or H at least in the first report I read. I find it unclear about what this drug is supposed to do specifically.

It frustrates me that they are coming up with more drugs to treat hearing damage just as it happens from a loud noise or trauma (ebselene compound, then there is another more potent one I can't remember), when for most of us the window of opportunity to reverse one or multiple damage events has long past. I'm so glad this is happening and people are recognizing that we need to broaden the window of opportunity.

 

[Foncky]

I understand their drug aims to protect the synapses (connexions between hair cells and auditory nerve).

But it's unclear if it's just made to prevent further damage or also to fix damaged synapses, at least partially.

Anyway, this is a great reminder that many companies are working hard for us and we don't know them all yet.

 

[Stakovic]

Don't raise your hope guys,it's just a candidate drug .

 

[Foncky]

Yes, a new candidate drug, but it's also an evolution of a candidate drug following encouraging preclinical tests.

A press release like that is always a good surprise. You never know what can be announced tomorrow by another company.

 

[Aaron123]

I understand their drug aims to protect the synapses (connexions between hair cells and auditory nerve).

Do you have a source for this? Everything I can find relates to vestibular issues.

Since SENS-401 is apparently a more effective "version" of SENS-218, this information might be useful:
"In the programme SENS-218, the target product profile defined was:

1. The targeted indication: protective treatment against permanent deficits following vestibular damage by a disease process.
2. The nature of the compound: a small molecule specific antagonist of the target in question.
3. The first line targeted patient population: patients suffering from inner ear dysfunction due to vestibular damage by a lesion (vestibular neuritis, Ménière's Disease, migrainous vertigo).
4. The type of administration envisaged: sublingual treatment for 4 weeks.
5. The expected effect: sustained reduction in signs of vestibular dysfunction (nystagmus, vertigo and loss of balance) and recovery/preservation of patient independence." (http://www.sensorion-pharma.com/en/sens218)

This suggests the target of may be vestibular issues rather than hearing. Their initial candidate (SENS-111) is for vertigo, and they recently reported a successful Phase 1b trial: http://www.sensorion-pharma.com/ima...9-21PR_Sensorion_AAO-HNSF_SENS-111_vf_eng.pdf

See also https://www.tinnitustalk.com/search/1352676/?q=sensorion&o=relevance for other information about Sensorion.

 

[Stakovic]

When they said Inner ear lesions ,do this mean Tinnitus ,H,hearing loss,vertigo...?

 

[Foncky]

Do you have a source for this? Everything I can find relates to vestibular issues.

Since SENS-401 is apparently a more effective "version" of SENS-218, this information might be useful:
[...]

I assume that since they talk a lot about hearing loss in the SENS-401 release, it might have the same role in the hearing part as SENS-218 had in the vestibular part, while still being useful in the vestibular part. But a different mechanism might be involved, that's true !

Quotes :
"Preliminary results from the preclinical studies with SENS - 401 in hearing loss resulting from acoustic trauma will be presented at the 46 th Annual Meeting of the Society for Neuroscience (SfN), Neuroscience 2016, which will be held on November 12 - 16 , 2016 in San Di e go, California."
or
"Sensorion has decided to select SENS - 401 , instead of 218 , as its final drug candidate for treating lesions of the inner ear" > "lesions of inner ear" could cover quite a large area...

@Stakovic on their website, they seem concerned about : vertigo, hearing loss, tinnitus and ototoxicity.

So in their pipeline is :
- SENS-111 (vertigo)
- SENS -300 (ototoxicity)
- SENS-218 now replaced by SENS-401 (vestibular and auditory lesions)

 

[Ian Mac]

I announced today I'll be developing ear141 for ear problems

 

[Mario martz]

God, it sound so good to be true, i hope it works!

 

[Foncky]

I announced today I'll be developing ear141 for ear problems

Ok, all drugs developments are bullshit and we should just live in anger because no one wants to cure hearing loss (and make loads of money with it)

I still hope your ear141 will be successful

 

[Mario martz]

I assume that since they talk a lot about hearing loss in the SENS-401 release, it might have the same role in the hearing part as SENS-218 had in the vestibular part, while still being useful in the vestibular part. But a different mechanism might be involved, that's true !

Quotes :
"Preliminary results from the preclinical studies with SENS - 401 in hearing loss resulting from acoustic trauma will be presented at the 46 th Annual Meeting of the Society for Neuroscience (SfN), Neuroscience 2016, which will be held on November 12 - 16 , 2016 in San Di e go, California."
or
"Sensorion has decided to select SENS - 401 , instead of 218 , as its final drug candidate for treating lesions of the inner ear" > "lesions of inner ear" could cover quite a large area...

@Stakovic on their website, they seem concerned about : vertigo, hearing loss, tinnitus and ototoxicity.

So in their pipeline is :
- SENS-111 (vertigo)
- SENS -300 (ototoxicity)
- SENS-218 now replaced by SENS-401 (vestibular and auditory lesions)

i wonder if it would work more on...
protecting the ear from damage on meniers attack...and stop them.
Or.. more like "okey you have tinnitus and hearing loss but you can take this pill and go everywhere you want, because it would protect you from further damage"

 

[jeannie]

There is one called cgf 166 I believe I seen it on another forum which is a ew drug.anyone??

 

[Vinnitus]

There is one called cgf 166 I believe I seen it on another forum which is a ew drug.anyone??

That one is the Novartis/Genvec project. CFG166 has been in development for quite some time.

 

[MikeP505]

I'm just thrilled when news releases about these studies and drugs get released. Sure hope it better leads to repairing and not just preventing!

 

[MikeL1972]

There will be a one-all cure one day and not in the distant future. Think about it like this: they can now treat Hep C and correct people's vision using a laser. These two incredible advancements would be unthinkable at one time. Now of course wearing eye glasses and contacts is not the worst thing in the world, but it is still a significant discovery.

As we gather on this site and others of its kind to help ourselves and help others, there is no doubt in my mind that eventually, science and medicine will catch up to tinnitus and it will be eliminated.

 

[MikeP505]

there is no doubt in my mind that eventually, science and medicine will catch up to tinnitus and it will be eliminated.

I'm all for that!!

 

[MikeP505]

True about the Hep C. Know someone personally who recently beat it with the new medications. He went thru hell with the medications but the end result was excellent!!

Can you just imagine a cure for Tinnitus?? I am not legally deaf in both ears and suffer this loud ringing in both ears 24/7/365. Bad enough dealing with deafness. Might be a tad easier if I had no ringing I tell yea!!

I am currently on a waiting list to have a Cochlear Implant done in my left ear to restore some hearing. When I read news of these treatments it gives me pause........ What happens if a drug comes out in the next 5 years that fixes much hearing and lowers much tinnitus?? Can I safely have my implant removed and this drug will still be effective in that ear? Am I risking other damages to nerves by having this surgery when a break thru is near? Should I wait? I mean I've waited long enough so far and really want to be able to even make a phone call again!! What will I feel like if I wait 3 4 or 5 years and still nothing comes out? Feel sort of caught in the middle of my own war here about everything. Chances are my surgery will happen within the next year so IF a drugs comes out it suuuuuuuuuuure would be nice if it happens fast!! lol

 

[MikeP505]

EDIT I am NOW legally deaf in both ears..........

 

[MikeL1972]

Chances are my surgery will happen within the next year so IF a drugs comes out it suuuuuuuuuuure would be nice if it happens fast!! lol

As you may know, it takes years for a drug to make it to market as the FDA is very stringent about such things - as well they should be! However, there is a "fast-track" designation as well when a drug is determined to help people (for example of those on a clinical trial had no side effects and were cured of Hep C) and patients could obtain immediate benefit.

Stem cells, gene therapy, etc. All of these avenues and others are being explored... It is not a matter of *if*, but a matter of when! Bank on it!!

 

[Mario martz]

As you may know, it takes years for a drug to make it to market as the FDA is very stringent about such things - as well they should be! However, there is a "fast-track" designation as well when a drug is determined to help people (for example of those on a clinical trial had no side effects and were cured of Hep C) and patients could obtain immediate benefit.

Stem cells, gene therapy, etc. All of these avenues and others are being explored... It is not a matter of *if*, but a matter of when! Bank on it!!

There has been a lot of FDA's "fast-track" for hearing loss meds.
the bad things is that they havent worked

 

[VRZ78]

True about the Know someone personally who recently beat it with the new medications. He went thru hell with the medications but the end result was excellent!!

Can you just imagine a cure for Tinnitus?? I am not legally deaf in both ears and suffer this loud ringing in both ears 24/7/365. Bad enough dealing with deafness. Might be a tad easier if I had no ringing I tell yea!!

I am currently on a waiting list to have a Cochlear Implant done in my left ear to restore some hearing. When I read news of these treatments it gives me pause........ What happens if a drug comes out in the next 5 years that fixes much hearing and lowers much tinnitus?? Can I safely have my implant removed and this drug will still be effective in that ear? Am I risking other damages to nerves by having this surgery when a break thru is near? Should I wait? I mean I've waited long enough so far and really want to be able to even make a phone call again!! What will I feel like if I wait 3 4 or 5 years and still nothing comes out? Feel sort of caught in the middle of my own war here about everything. Chances are my surgery will happen within the next year so IF a drugs comes out it suuuuuuuuuuure would be nice if it happens fast!! lol

Maybe go for the Novartis trial before ? Ends August 2017.

 

[MikeP505]

Quick question for everyone here. How do you find about these trials and what steps do you take to apply to be in these trials? Of course if anyone is going to get involved in a trial you would want it happening in your area and do these trial notices tell you where the trials are taking place?

 

[VRZ78]

Everything's written here :
https://clinicaltrials.gov/ct2/show/study/NCT02132130#contacts

The study takes place in Kansas City, Baltimore or New York

 

[Ian Mac]

I am now developing Tin132 for treatment of ear problems.

 

[Codaz]

There will be a one-all cure one day and not in the distant future. Think about it like this: they can now treat Hep C and correct people's vision using a laser. These two incredible advancements would be unthinkable at one time. Now of course wearing eye glasses and contacts is not the worst thing in the world, but it is still a significant discovery.

As we gather on this site and others of its kind to help ourselves and help others, there is no doubt in my mind that eventually, science and medicine will catch up to tinnitus and it will be eliminated.

Don't get your hopes up high. Since I developed T (and facial pain) I became a regular at hospitals. Its a place you never would like to visit. Not even for the friendly nurses. The painstaking slow process of development in health science is making people nervous, angry and also jealous as some treatments are costly or not available in a country. For example some cancer treatments are only in Germany, not in other countries of the EU. All bullshit politics, driven by price, lack of spreading of knowledge etc.

I imagined being a doctor, selling NO to every client for 30 years that came into my office with a decease they know nothing about or cannot treat. Seems to me as a very bad job.

I hope that there will be a cure, I really do. But you cannot deny that the hopes are small since T is not directly deadly (indirect it can be). Direct causes of death are researched first or more intensively.

What I hope is that new quantum computers can calculate us a drug. Their power is far more advanced than we actually think of right now. On Alzheimers decease now big data is gathered to find a possible explanation why some people reach 80 and others only 60, what the treatment could be is even further away.

 

[Foncky]

@Codaz , tinnitus may not be a priority (can we blame the world for that, when dozens of horrible diseases are not curable ?), but hearing loss is a HUGE field where big money can be made.

So a lot of research is going on for treating hearing loss. And T and H sufferers will benefit from this.

As said earlier, it's no longer a question of 'if", but of "when".

@MikeP505 : you're facing a difficult choice. Cochlear implant might compromise your chances to get a more effective treatment one day, and there is a risk of T worsening I believe ? It's really hard, maybe you should start a thread to get plenty of insights because it's a vital question for you.

 

[Mario martz]

mmm there are more attention in the ears right now, more than ever..