Stemetil (Prochlorperazine) Improves My Tinnitus

Discussion in 'Support' started by Jeff Bannister, Aug 16, 2021.

    1. Jeff Bannister

      Jeff Bannister Member

      Tinnitus Since:
      25/12/2020
      Cause of Tinnitus:
      Unknown
      Hi,

      By accident, I discovered that taking Stemetil 5 mg will significantly lower the amount of head ringing I have in my head but only the next day. My tinnitus has 2 modes, ringing in just my right ear, or my head buzzes like a dimmer switch. The latter mode is extremely difficult to live with and am trying everything I can to find a fix. I guess there must be a way out of this if I'm prepared to put in the effort.

      I note that the mechanism of action for Stemetil is to block dopamine uptake and it is usually prescribed for nausea/motion sickness etc.

      Does anyone on this forum have any experience with taking Stemetil? Any theories why I see little benefit until the next day? I've also been taking a real low dose i.e. 5-10 mg per day, the max I believe is 30 mg per day.

      I am going to take a month-long trial under my doctor's supervision, but let's face it people on this forum tend to know more than the doctors, so thought I'd ask the experts.

      /Jeff.
       
      • Like Like x 6
    2. Cernuto
      Spaced

      Cernuto Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Noise Induced
      So you take the pill at night and it kicks in the next day? Does it only work for one day? How often does your tinnitus go through the two modes?
       
    3. Ehren M
      Nerdy

      Ehren M Member

      Location:
      USA
      Tinnitus Since:
      01/24/2021
      Cause of Tinnitus:
      acoustic trauma
      Thanks for sharing, Jeff. I haven't heard of this, but I have an appointment coming up with my doctor, and I'll definitely ask him about his thoughts on it. He has a degree in biochemistry, so it should at least make for good discussion.

      I look forward to hearing about how your longer trial of Stemetil goes.

      Cheers
       
      • Useful Useful x 1
    4. AUTHOR
      AUTHOR
      Jeff Bannister

      Jeff Bannister Member

      Tinnitus Since:
      25/12/2020
      Cause of Tinnitus:
      Unknown
      I've done 4 trials where I take the tablet at about 2 pm and it kicks in the next day, sometimes about 24 hours later. It can also give me up to 1.5 days benefit so quite a long tail.

      My tinnitus is about 70% the head ringing (ear also rings) and 30% just the ear.
       
      • Informative Informative x 1
    5. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      beliefs are makyo and reality ignores them
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      It's a d2 dopamine agonist.

      Dopamine receptor target drugs have shown some efficiency in the treatment of some people's tinnitus but I am not aware of any large-sample size blinded study that's been able to demonstrate any kind of consistent effect.

      So, this gets into the realm of stuff which might help some small subset of people, but the only way to find out is to try, and if it works for you you get to be a medical mystery that none of your doctors really understand.
       
    6. Matchbox
      Wishful

      Matchbox Member

      Location:
      BC Canada
      Tinnitus Since:
      08/2020
      Cause of Tinnitus:
      Noise Induced, Prednisone (drones), Barotrauma (distortions)
      I wonder if there's any connection to prolactin here.
       
      • Good Question Good Question x 1
    7. Cernuto
      Spaced

      Cernuto Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Noise Induced
      Jeff, please keep us updated with your trials of Stemetil. I would like to try it myself.

      It would be interesting to get a blood panel done just before you take the Stemetil and again a day later when you are seeing the benefit, then compare the two blood panels.
       
    8. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      This is why I take Pramipexole - it's much worse without it.
       
      • Useful Useful x 1
    9. Óscar PP
      Psychedelic

      Óscar PP Member

      Tinnitus Since:
      Nov 2020
      Cause of Tinnitus:
      Coronavirus
      I think I asked you already, but what kind of tinnitus do you have (ringing, buzzing, hiss...)? And by how much does it improve with Pramipexole?
       
    10. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      I have multiple noises that rotate, but predominantly hissing and ringing - I would say the pramipexole knocks it down from an 8-9/10 to a 6-8/10 on average.
       
      • Like Like x 1
    11. AUTHOR
      AUTHOR
      Jeff Bannister

      Jeff Bannister Member

      Tinnitus Since:
      25/12/2020
      Cause of Tinnitus:
      Unknown
      Hi,

      I thought I would write a reply for those that raised interest in my original post. I got a range of tablets from the doctor 1) Loratadine (anti-histamine), 2) Stemetil (Prochlorperazine), 3) Kwells travel sickness tablets (Hyoscine Hydrobromide)

      I was planning on taking each for a week to see what would happen.

      1) Anti-histamine
      Immediately caused my tinnitus to get louder. I stuck with it for few days and it didn't help so I stopped, after stopping my tinnitus went back to base levels.

      2) Hyoscine Hydrobromide
      Caused me to be very sleepy and I became very weak. Around this time I developed balance issues, and a crushing headache. Maybe complete coincidence.

      3) Prochlorperazine
      Caused me to feel great, tinnitus reduced the next day after taking. However, it brought back my depression which I suffered really badly at the start of the year, so I stopped. I simply cannot go back to that period as I would constantly think about how to kill myself.

      On looking more into Prochlorperazine I realized how dangerous it is to take this tablet long-term. This tablet is typically used for acute episodes of nausea and vertigo etc. If you take this long term (years) then you can develop Parkinsonism syndrome which is horrific.

      I wanted to ensure I updated the post just in case anyone didn't have all the info with which to make their decisions. Everyone is free to do what they want, but they need all the facts.

      Also, as I've recently developed tension like headaches, vertigo-like symptoms (like I'd got off a boat) and some nausea, I've been looking for some pharmacology to help with that. Stemetil would definitely help here but not willing to take it for the reasons I mentioned earlier. I wonder if that caused my tension-like problems, also not sure if this could have caused my tinnitus in the first place (always thought that).

      Having felt like this for 3 weeks now, in desperation I decided to take Robaxin (Methocarbamol) which is a muscle relaxant I was given a few years back for a back issue. I took 5 tablets, each one 750 mg, in a single day (below the max dose) and my tension headache, blocked and painful ears were massively reduced. Balance at least 70% better. Interestingly the next day, my tinnitus had completely gone away, for at least 1/2 a day - WTF! Did I discover my tinnitus is related to muscle tension or a muscle issue in my neck/back? I've also had a somatic component to my tinnitus e.g., opening my mouth makes my tinnitus louder, turning the head one way causes the tinnitus to start in the opposite ear, turning the other way, the tinnitus volume increases by 500% and so on.

      Just thought I'd share what I'd learnt just in case it helps someone. I will definitely be trying Robaxin again, especially if my tinnitus gets really bad.
       
      • Informative Informative x 2
    12. ma7555
      Doubtful

      ma7555 Member

      Tinnitus Since:
      04/2022
      Cause of Tinnitus:
      Bupropion
      It is dopamine antagonist, like antipsychotics.
       
    13. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      beliefs are makyo and reality ignores them
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      Quite right, thanks for the correction.
       
    14. Nick47

      Nick47 Member Benefactor Hall of Fame

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      Just took Prochlorperazine 5 mg. I have dizziness so decided to bite the bullet and take one from an old prescription. An hour later my tinnitus has dropped minimally ~10-15%.

      I will report back tomorrow on any change or not.
       
      • Informative Informative x 1
    15. Nick47

      Nick47 Member Benefactor Hall of Fame

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      Well I woke up and it was as quiet as it has been in the morning after a 5 mg pill yesterday afternoon. Could be a coincidence so far. Mood is ok though and seems like it had an anti-anxiety effect, completely different to the benzo anti-anxiety but drugged feeling. Feeling calm.
       
      • Helpful Helpful x 1
    16. Lane

      Lane Member Hall of Fame

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      Single 25 mg dose of (anticholinergic) drug Promethazine
      Hi @Nick47 -- Just to mention, Prochlorperazine is an anticholinergic drug, the same class of drug that gave me screeching tinnitus and may have given me a form of chronic akathisia. -- Take care!

      Nervous system
      Prochlorperazine can cause akathisia. Of 100 patients with severe headache or nausea who received prochlorperazine 10 mg intravenously, 44 developed akathisia within 1 hour; none of the 40 patients who received other medications, and who served as controls, developed akathisia.
       
      • Informative Informative x 1
    17. Nick47

      Nick47 Member Benefactor Hall of Fame

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      @Lane, no worries. It was actually prescribed a while back when I had labyrinthitis. I take a lower dose, 5 mg yesterday and 2.5 mg today.

      What drug did you take?
       
      • Like Like x 1
    18. Nick47

      Nick47 Member Benefactor Hall of Fame

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      Just an update. I took 5 mg of Prochlorperazine again yesterday and today my tinnitus has been 3-5/10 with much less reactivity. Still could be a coincidence and I do not want to take it regularly.
       
    19. Nick47

      Nick47 Member Benefactor Hall of Fame

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      Last update from me on this. I took Prochlorperazine for the 3rd time (5 mg) and it reduced anxiety, made me a bit depressed, and I woke up the next day with lower tinnitus volume and reactivity. This happened too often to be a coincidence. No more reports from me on this in the future.

      It is commonly prescribed in the UK for nausea and dizziness.
       
      • Informative Informative x 2
      • Like Like x 1
    20. AST

      AST Member

      Tinnitus Since:
      29/4/2021
      Cause of Tinnitus:
      Stress
      Did your tinnitus remain low once you stopped taking it?
       
      • Good Question Good Question x 1
    21. Nick47

      Nick47 Member Benefactor Hall of Fame

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      @AST, it remained low only the next day. It seems dopamine modulating medications can affect tinnitus, as other people have reported getting some effect from them too. I have a prescription for other dopamine modulators, although I'm having a tough time obtaining them. If taken regularly, you need to speak to a doctor as long-term use could cause side effects.
       
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