Sulodexide Possibly Benefits Chronic Tinnitus

Discussion in 'Research News' started by Emmi, Oct 6, 2016.

    1. AmePerdue

      AmePerdue Member Benefactor

      Location:
      France
      Tinnitus Since:
      May 10, 2021
      Cause of Tinnitus:
      Unknown - Likely ear infection
      @marcjrf, I got one box at the pharmacy in terminal 4 of Madrid Barajas airport. You can email them beforehand, in my experience they answer pretty quickly. I emailed them in Spanish.
       
    2. Ultra

      Ultra Member

      Location:
      Europe..
      Tinnitus Since:
      2021
      Cause of Tinnitus:
      Unknown
      Was anyone else able to get hold of Sulodexide and try it?
       
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    3. Tomas80

      Tomas80 Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknow. Maybe stress?
      Sulodexide for 21 days, 2x daily, with Melatonin every evening, no change :(
       
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    4. 2noist

      2noist Member

      Tinnitus Since:
      04/2015
      Sorry to hear that but thanks for taking one for the team.
       
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    5. kestokas

      kestokas Member

      Location:
      Lithuania
      Tinnitus Since:
      02/2021
      Cause of Tinnitus:
      COVID-19
      I've been taking Sulodexide for 12 days with Melatonin. I will continue for 30 days. We'll see how it goes.
       
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    6. ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      Any positive result yet so far?!
       
    7. kestokas

      kestokas Member

      Location:
      Lithuania
      Tinnitus Since:
      02/2021
      Cause of Tinnitus:
      COVID-19
      I think I am start getting positive results so far.

      But I'll wait at least for 30 days of taking Sulodexide and some time after discontinuation, to see if it is not placebo and results are sustainable.

      Then I'll shed more details.
       
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    8. Mangels

      Mangels Member

      Tinnitus Since:
      One year
      Cause of Tinnitus:
      I don't know
      Hi kestokas,
      could you please tell us how your experience is going. I live in Spain and considering talking about this with my social security doctor. Thank you.
       
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    9. Mangels

      Mangels Member

      Tinnitus Since:
      One year
      Cause of Tinnitus:
      I don't know
      Hi AmePerdue. It's now two months later, are you now doing the treatment? How is it going?
       
    10. AmePerdue

      AmePerdue Member Benefactor

      Location:
      France
      Tinnitus Since:
      May 10, 2021
      Cause of Tinnitus:
      Unknown - Likely ear infection
      Hi Mangels,

      I gave up on it after my last update due to lack of noticeable effect. The capsules are still sitting in my drawer.
       
    11. Mangels

      Mangels Member

      Tinnitus Since:
      One year
      Cause of Tinnitus:
      I don't know
      Hi AmePerdue,
      Thank you for informing, I will try it, my social security doctor thinks it may be a good option and has prescribed them for me. I will be updating the information.
       
    12. Alexandras
      Balanced

      Alexandras Member

      Tinnitus Since:
      2020-07
      Cause of Tinnitus:
      SSHL
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    13. Alexandras
      Balanced

      Alexandras Member

      Tinnitus Since:
      2020-07
      Cause of Tinnitus:
      SSHL
      Ok, starting Sulodexide today: Vessel Due F 250 LSU capsule.

      Twice a day.
       
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    14. Watasha
      No Mood

      Watasha Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
      03/2018
      Cause of Tinnitus:
      Unknown
      Is your plan to take one in the morning and one in the evening for 40 days?
       
    15. Alexandras
      Balanced

      Alexandras Member

      Tinnitus Since:
      2020-07
      Cause of Tinnitus:
      SSHL
      In the beginning, yes. However, I believe that after 30 days, I will increase the dosage to 4 pills, since I have read that it is a very safe drug used for preventive purposes, etc., with no risk of bleeding.

      And I opted not to take it with Melatonin because (just in my opinion!) Melatonin works by soothing the nervous system and creating the perception of diminished tinnitus (temporarily).

      Nonetheless, I have no expectations. My tinnitus has a very evident cause: I lost part of my hearing as a result of an SSHL episode, and some of my synapses simply perished.

      I'm not sure how a medicine that enhances blood flow may help in such a situation.
       
    16. Alexandras
      Balanced

      Alexandras Member

      Tinnitus Since:
      2020-07
      Cause of Tinnitus:
      SSHL
      Update:

      I need to say that I am trying Suledoxide after very, very huge spike I got during my flu/pharyngitis episode.

      After I started to take the pills, the spike dropped to the baseline. I doubt that it is because of Sulodexide, probably just a lucky coincidence. I will continue to take the Sulodexide, of course, and see what happens further.
       
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    17. Alexandras
      Balanced

      Alexandras Member

      Tinnitus Since:
      2020-07
      Cause of Tinnitus:
      SSHL
      Unfortunately, there was a small spike again yesterday, so in addition to the Sulodexide, I used the only supplement (from many I tested) that actually works for me: natural Saffron spice, extracted by 20 mg of vodka. I awoke in near silence (the silent days are the ones I forgot I am having the tinnitus). I believe this is a Saffron impact rather than a Sulodexide effect because there has been insufficient time for it to occur.

      For the time being, I'll add Saffron for one week and then continue with Sulodexide only to see how things go.
       
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    18. volsung37

      volsung37 Member Benefactor

      Tinnitus Since:
      2014
      I tried Saffron a few years ago and it definitely did reduce the level of my tinnitus somewhat.
       
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    19. Freerunner

      Freerunner Member

      Tinnitus Since:
      10/2021
      Cause of Tinnitus:
      Caloric test
      Was the result long lasting?
       
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    20. Ctjbush
      Alienated

      Ctjbush Member

      Tinnitus Since:
      August 2018
      Cause of Tinnitus:
      Probably loud music, old age
      Hi, I’ve never seen Saffron mentioned on the forum before. Can you provide more information? Amount, form, etc.? Thanks.
       
    21. SB1981

      SB1981 Member Benefactor

      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Multifactorial
      What brand of Saffron spice? What do you mean extracted by 20 mg of vodka?
       
    22. SB1981

      SB1981 Member Benefactor

      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Multifactorial
      What Saffron did you use?
       
    23. Alexandras
      Balanced

      Alexandras Member

      Tinnitus Since:
      2020-07
      Cause of Tinnitus:
      SSHL
      No, Saffron is not long lasting, and actually it seems that your body quickly adjusts to its effects, so it's not a cure. But it may relax you.

      Saffron seems to work like an actual anti-depressant drug. Something like that:

      Saffron (Crocus sativus L.): As an Antidepressant
      Here is the topic and you may find some useful info

      Saffron Cure for Tinnitus?
      I don't think it is important what brand, I used one from Spain. Just be sure it is a real one, not a fake.

      I am mixing around 15-20 sticks with 20 g of vodka.

      But it seems you can extract the active material maybe also with milk.
       
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    24. Mangels

      Mangels Member

      Tinnitus Since:
      One year
      Cause of Tinnitus:
      I don't know
      Update:

      I have been taking Sulodexide (Dovida) 30 mg twice a day.

      A week later I had to stop treatment because there was a significant worsening.

      I rested for a week and gave it another chance with the same result, worsening.

      I suspect it was not the active ingredient, Sulodexide, but the excipients, this is what the package insert says:

      Warnings on excipients: This medicine can cause allergic reactions because it contains Orange Yellow S (E-110) and Cochineal Red A (E-124). May cause asthma, especially in patients allergic to aspirin. May cause allergic reactions (possibly delayed) because it contains sodium ethyl parahydroxybenzoate (E-215) and sodium propyl parahydroxybenzoate (E-217).​

      Unfortunately, the other commercial brand available in Spain, Aterina, has the same presentation of soft capsules and the same excipients.

      Consequently, the experience with Sulodexide has not been positive and if it is attributable to the excipients as I suspect, I cannot contribute anything regarding the effect of Sulodexide on tinnitus.
       
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    25. 2noist

      2noist Member

      Tinnitus Since:
      04/2015
      That's a huge shame, but it's great you found the probable cause for the worsening. One more data point for the rest of us...
       
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    26. Alexandras
      Balanced

      Alexandras Member

      Tinnitus Since:
      2020-07
      Cause of Tinnitus:
      SSHL
      UPDATE:

      I've taken Sulodexide for almost two months.

      The main side effect is an some aggravation of my pre-existing gastric reflux disorder. But bearable.

      The main conclusion so far: it's helping my tinnitus somehow. It doesn't really treat or cure it, but it somehow reduces, not the base level itself, but the amount and intensity of spikes. They have been low throughout the whole period of taking it, maybe a couple of small, quickly subsiding spikes.

      Before Sulodexide the amount and intensity of spikes were higher.

      I want to continue taking it and see if I can get more benefit. Later I will try to stop and see if the perceived benefits persist.
       
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    27. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      Are you still taking it? How was your tinnitus caused?
       
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