Sulodexide Possibly Benefits Chronic Tinnitus

Hello everyone,

I was in contact with a doctor from St. Joseph University in Beirut and wanted to participate in a Tinnitus study. He told me that they unfortunately enrolled it already and the preliminary results showed a benefit in treating tinnitus with sulodexide (as known as Vessel Due F).

https://clinicaltrials.gov/ct2/show/NCT02737670?term=tinnitus&rank=69

http://en.medicine-worlds.com/vessel-due-f.htm

Thought I'd let you know, I might give it a try. The side effects seem justifiable.

 

Interesting. The wikipedia page for it refers to a study where participants experienced improvement in tinnitus when combining sulodexide + melatonin.

This is the study it links to:

https://www.ncbi.nlm.nih.gov/pubmed/19589291

Could be worth a shot.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808686/

"When comparing our results, it showed that patients who received MS (Group A) had a consistent improvement in THI and acufenometry (79.4%). The outcome in Group B in which tinnitus was treated with Melatonin alone showed an improvement in QoL, when evaluated with THI and acufenometry in 58.8%."

 

It's unfortunate that the study didn't include a placebo group... we can't tell if the improvements are due to placebo effects.

 

Emmi
Hi there do you have any hearing loss? if so whats your numbers. also what does your T sound like. mine is a sizzling in my head with a ring in it. it started 18 months ago, it has detroyed me and everything i ever worked for.
thanks
Rick

 

Agreed, such a basic scientific necessity but they didn't do it...

 

Hi Rick,
no detectable hearing loss, but did not do a high frequency audio-gram.. it is sort of a hiss in both of my ears. And yes destroyed everything for me as well..

 

About the subject of this thread: https://clinicaltrials.gov/ct2/show/NCT02737670
This clinical trial is placebo controlled.
Status: this study has been completed. Study completion date: August 2017.

I did not find any results. So I sent an e-mail today to Elias Eter and Joseph Maarrawi, the contacts of the Faculty of Medecine of Saint Joseph University of Beirut, to ask for the results.

 

Please let us know the results when you get them. Thank you very much!

 

How can we get hold of this drug??

 

I thought they did? I says;
Condition Intervention Phase
Tinnitus, Subjective Drug: Sulodexide
Drug: Placebo
Phase 2

Unless I'm reading the wrong thing :-/

 

what about how much it cost,if i read it right it would be huge cost in us dollers

 

The results have been published:
https://www.ncbi.nlm.nih.gov/pubmed/29712507

The full article is freely available, too!
http://journals.sagepub.com/doi/full/10.1177/0194599818767618

Sulodexide Monotherapy in Chronic Idiopathic Subjective Tinnitus: A Randomized Controlled Trial.

 

Where can we buy this drug?

 

It’s an interesting study for sure and I hope they will do a follow-up study on it soon! Has anyone on the forum tried this?

 

I think you get a prescription from a doctor.

 

Go to a shrink. And check out my thread.

 

Anyone already trying it?

 

I wish I tried Sulodexide but it is not available in France.

 

"We chose a sulodexide dosage of 25 mg to facilitate the comparison of our findings to those of previous studies. Both groups took 1 tablet of the drug/placebo each morning and evening for 40 days."

Sorry for the stupid question but did they take 25mg per day or per tablet (50mg per day)? I could ask my GP, knowing him he would probably prescribe it, the possible side effects really don't seem too bad (if it's available in my country).

 

It sounds like they took both a 25mg pill in the morning and evening.

 

i'm from istanbul, turkey. and i can try it and also i'll try.
i'll let you inform.

 

To distill this to the important info for anyone visiting the thread. Placebo group had 61 people, the Sulodexide group had 63 people. They took the drug or placebo for 40 days morning and night. The placebo group's Tinnitus Handicap Inventory (THI) went from 41.3 to 40.5, or basically no improvement. While the Sulodexide group's THI went from 40.4 to 30.1. That seems to me like quite a substantial improvement for those suffering.

The main side effects are stomach pain and constipation in under 10% of people.

Here is the THI https://starkeypro.com/pdfs/THI_Questionnaire.pdf
One thing I noticed is that a lot of questions are based on your reaction to tinnitus so I'm wondering whether the drug has an effect on the noise of just your reaction to it.

The drug was only taken for 40 days. Who knows if those scores will go down even further by taking it longer.

This is the closest thing I've seen to a pill helping except for Benzos which have bad side effects and might make it worse in the long run.

 

Does this pill have any withdrawal effects like benzos that could potentially make your tinnitus worse?

 

40.4 to 30.1 what though? Percent?

 

If you look at the THI questionaire, you answer the questionnaire and there is a formula at the bottom to calculate your score.

 

Hmm, maybe I'll talk to my GP about this when she returns from maternity leave. She's pretty open minded so maybe I could get her to prescribe it.

 

Sooo.. anyone else tried it yet?

 

This a weird drug in terms of mode of action, it's hard to figure out why it would impact tinnitus. Does it have something to do with circulation?

 

Is it a bad sign that the study was published on april fool's day?