Sulodexide Possibly Benefits Chronic Tinnitus

Discussion in 'Research News' started by Emmi, Oct 6, 2016.

    1. Emmi
      Not amused

      Emmi Member

      Tinnitus Since:
      November 2015
      Cause of Tinnitus:
      Noise Exposure
      Hello everyone,

      I was in contact with a doctor from St. Joseph University in Beirut and wanted to participate in a Tinnitus study. He told me that they unfortunately enrolled it already and the preliminary results showed a benefit in treating tinnitus with sulodexide (as known as Vessel Due F).

      https://clinicaltrials.gov/ct2/show/NCT02737670?term=tinnitus&rank=69

      http://en.medicine-worlds.com/vessel-due-f.htm

      Thought I'd let you know, I might give it a try. The side effects seem justifiable.
       
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    2. Champ
      Woot

      Champ Member Benefactor

      Location:
      Boston, MA
      Tinnitus Since:
      01/2013
      Cause of Tinnitus:
      Acoustic trauma from headphones
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    3. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise or maybe... unicorns!
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808686/

      "When comparing our results, it showed that patients who received MS (Group A) had a consistent improvement in THI and acufenometry (79.4%). The outcome in Group B in which tinnitus was treated with Melatonin alone showed an improvement in QoL, when evaluated with THI and acufenometry in 58.8%."
       
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    4. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      It's unfortunate that the study didn't include a placebo group... we can't tell if the improvements are due to placebo effects.
       
      • Agree Agree x 1
    5. rid0871

      rid0871 Member

      Tinnitus Since:
      may of 2015
      Cause of Tinnitus:
      had my neck adjusted
      Emmi
      Hi there do you have any hearing loss? if so whats your numbers. also what does your T sound like. mine is a sizzling in my head with a ring in it. it started 18 months ago, it has detroyed me and everything i ever worked for.
      thanks
      Rick
       
    6. Champ
      Woot

      Champ Member Benefactor

      Location:
      Boston, MA
      Tinnitus Since:
      01/2013
      Cause of Tinnitus:
      Acoustic trauma from headphones
      Agreed, such a basic scientific necessity but they didn't do it...
       
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    7. AUTHOR
      AUTHOR
      Emmi
      Not amused

      Emmi Member

      Tinnitus Since:
      November 2015
      Cause of Tinnitus:
      Noise Exposure
      Hi Rick,
      no detectable hearing loss, but did not do a high frequency audio-gram.. it is sort of a hiss in both of my ears. And yes destroyed everything for me as well..
       
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    8. Frédéric

      Frédéric Member Benefactor

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      About the subject of this thread: https://clinicaltrials.gov/ct2/show/NCT02737670
      This clinical trial is placebo controlled.
      Status: this study has been completed. Study completion date: August 2017.

      I did not find any results. So I sent an e-mail today to Elias Eter and Joseph Maarrawi, the contacts of the Faculty of Medecine of Saint Joseph University of Beirut, to ask for the results.
       
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    9. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      Please let us know the results when you get them. Thank you very much!
       
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    10. Emanuel Lourenco
      Depressed

      Emanuel Lourenco Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Noise exposure, repeatedly worsened by the great mystery T
      How can we get hold of this drug??
       
    11. Paul10

      Paul10 Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Stress
      I thought they did? I says;
      Condition Intervention Phase
      Tinnitus, Subjective Drug: Sulodexide
      Drug: Placebo
      Phase 2

      Unless I'm reading the wrong thing :-/
       
    12. Lost life
      Alone

      Lost life Member

      Location:
      san francisco california
      Tinnitus Since:
      3-17
      Cause of Tinnitus:
      benzo w/d noise/trauma ,stress,tmj,hearing loss
      what about how much it cost,if i read it right it would be huge cost in us dollers
       
    13. beeeep

      beeeep Member

      Location:
      Germany
      Tinnitus Since:
      ~2000, but real bad since 06/2015
      Cause of Tinnitus:
      Unknown
      The results have been published:
      https://www.ncbi.nlm.nih.gov/pubmed/29712507

      The full article is freely available, too! ;)
      http://journals.sagepub.com/doi/full/10.1177/0194599818767618

      Sulodexide Monotherapy in Chronic Idiopathic Subjective Tinnitus: A Randomized Controlled Trial.

       
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    14. alex01

      alex01 Member

      Tinnitus Since:
      01/2018
      Cause of Tinnitus:
      ear wax removal
      Where can we buy this drug?
       
      • Good Question Good Question x 1
    15. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      It’s an interesting study for sure and I hope they will do a follow-up study on it soon! Has anyone on the forum tried this?
       
    16. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      I think you get a prescription from a doctor.
       
    17. Anselmo

      Anselmo Member Benefactor

      Location:
      Miami, Florida
      Tinnitus Since:
      1/14
      Cause of Tinnitus:
      Aspirin
      Go to a shrink. And check out my thread.
       
    18. noitseuq

      noitseuq Member

      Tinnitus Since:
      Right 2006. Left 2017
      Cause of Tinnitus:
      loud music
      Anyone already trying it?
       
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    19. Frédéric

      Frédéric Member Benefactor

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      I wish I tried Sulodexide but it is not available in France.
       
    20. Autumnly
      Wishful

      Autumnly Member Benefactor Hall of Fame

      Tinnitus Since:
      July/August 2013
      Cause of Tinnitus:
      Noise induced
    21. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      It sounds like they took both a 25mg pill in the morning and evening.
       
      • Helpful Helpful x 1
    22. Fatih
      Disapproved

      Fatih Member

      Tinnitus Since:
      March 2017
      Cause of Tinnitus:
      Tympanoplasty
      i'm from istanbul, turkey. and i can try it and also i'll try.
      i'll let you inform.
       
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    23. EarHair

      EarHair Member

      Location:
      Vancouver, Canada
      Tinnitus Since:
      11/2012 worsened Jan 2018
      Cause of Tinnitus:
      Concerts and TMJ and genetics (Mom, Grandpa have it)
      To distill this to the important info for anyone visiting the thread. Placebo group had 61 people, the Sulodexide group had 63 people. They took the drug or placebo for 40 days morning and night. The placebo group's Tinnitus Handicap Inventory (THI) went from 41.3 to 40.5, or basically no improvement. While the Sulodexide group's THI went from 40.4 to 30.1. That seems to me like quite a substantial improvement for those suffering.

      The main side effects are stomach pain and constipation in under 10% of people.

      Here is the THI https://starkeypro.com/pdfs/THI_Questionnaire.pdf
      One thing I noticed is that a lot of questions are based on your reaction to tinnitus so I'm wondering whether the drug has an effect on the noise of just your reaction to it.

      The drug was only taken for 40 days. Who knows if those scores will go down even further by taking it longer.

      This is the closest thing I've seen to a pill helping except for Benzos which have bad side effects and might make it worse in the long run.
       
      • Optimistic Optimistic x 1
    24. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      Does this pill have any withdrawal effects like benzos that could potentially make your tinnitus worse?
       
    25. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      40.4 to 30.1 what though? Percent?
       
    26. EarHair

      EarHair Member

      Location:
      Vancouver, Canada
      Tinnitus Since:
      11/2012 worsened Jan 2018
      Cause of Tinnitus:
      Concerts and TMJ and genetics (Mom, Grandpa have it)
      If you look at the THI questionaire, you answer the questionnaire and there is a formula at the bottom to calculate your score.
       
    27. derpytia
      Pooptoast

      derpytia Member Benefactor

      Location:
      Rescue, California
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Hearing loss / ETD
      Hmm, maybe I'll talk to my GP about this when she returns from maternity leave. She's pretty open minded so maybe I could get her to prescribe it.
       
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    28. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      Sooo.. anyone else tried it yet?
       
      • Good Question Good Question x 2
    29. Cal18
      Nerdy

      Cal18 Member Benefactor Advocate

      Location:
      San Diego
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      2010 / 2016 Both SSRI Withdrawal and Mild Hearing Loss
      This a weird drug in terms of mode of action, it's hard to figure out why it would impact tinnitus. Does it have something to do with circulation?
       
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    30. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      Is it a bad sign that the study was published on april fool's day? ;)
       
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