Sulodexide Possibly Benefits Chronic Tinnitus

Discussion in 'Research News' started by Emmi, Oct 6, 2016.

    1. Leon909
      Ape-like

      Leon909 Member

      Tinnitus Since:
      09/2015
      After revieweing sulodexide and it's potential side effects in detail, I decided to give it a try. I've been taking it for about a week. My dosage is 60mg per day, which makes it a little higher than that used in the study. On day 3-4 I've had some pain in the hip and upper leg area. Other than that I couldn't notice any adverse effects. So far I can't really say anything about its effects on my tinnitus. The cost was 50 € for a 45-day treatment. I'll post again in a couple of weeks or after finishing the 45 days.
       
      • Like Like x 7
      • Informative Informative x 3
    2. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      @Leon909 how did you get your tinnitus? What is the cause?

      And thank you for keeping us updated.
       
      • Good Question Good Question x 1
    3. Garye
      Thinking

      Garye Member

      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      ??
      Send to
      Otolaryngol Head Neck Surg. 2018 Jun;158(6):1107-1112. doi: 10.1177/0194599818767618. Epub 2018 May 1.
      Sulodexide Monotherapy in Chronic Idiopathic Subjective Tinnitus: A Randomized Controlled Trial.

      El Beaino M1, McCaskey MK2, Eter E1.
      Author information
      Abstract


      Objective To report the therapeutic value of sulodexide monotherapy in the management of patients with chronic subjective idiopathic tinnitus. Study Design Randomized double-blinded controlled trial. Setting Single tertiary care institution. Subjects and Methods Observations from 124 patients who received either sulodexide or placebo were collected from the patients' medical records. Computer-generated tables were used to allocate treatments. Patients took 1 tablet of the drug or placebo each morning and evening for 40 consecutive days. The response was assessed by the Tinnitus Handicap Inventory and the Mini-Tinnitus Questionnaire. Results Between 2014 and 2017, 124 patients were divided into 2 treatment arms. The sulodexide group encompassed 63 patients, whereas the placebo arm contained 61 patients. Tinnitus Handicap Inventory and Mini-Tinnitus Questionnaire scores were more decreased in the sulodexide arm compared to the placebo group ( P = .03 and P < .01, respectively). Conclusions Sulodexide monotherapy decreases chronic subjective idiopathic tinnitus.
      KEYWORDS:

      Mini-Tinnitus Questionnaire; Tinnitus Handicap Inventory; anticoagulant; randomized controlled trial; sulodexide; tinnitus
      PMID:
      29712507
      DOI:
      10.1177/0194599818767618
       
      • Informative Informative x 1
    4. Tigo

      Tigo Member

      Tinnitus Since:
      2 years
      Cause of Tinnitus:
      genetic hearing loss
      • Agree Agree x 3
    5. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      This indeed is very interesting!

      From: Treatment of central and sensorineural tinnitus
      with orally administered Melatonin and Sulodexide:
      personal experience from a randomized controlled
      study

      (https://www.ncbi.nlm.nih.gov/pubmed/20111618)

      "In Group A, the THI and acufenometry, at the end of the treatment period, showed an improvement. The initial THI mean was 41.1 (SD 21.9) and the final THI mean was 36.5 (SD 20.8); the initial acufenometry mean was 44.1 (SD 20.2) and the final acufenometry mean was 36.7 (SD 20.5). The differences between these mean values were statistically significant."

      From: Textbook of Tinnitus
      (https://books.google.se/books?id=YS...BLkQ6AEIYDAJ#v=onepage&q=acufenometry&f=false)

      "Acufenometry is the technique used to determine the frequency range (pitch) of tinnitus, its subjective intensity (loudness), the ability of sounds to mask the tinnitus of an individual person, and the residual inhibition of tinnitus."


      That means that the improvement is not only in THI scores but the tinnitus also seems to have been perceived as less loud.

      What's even more interesting is that the scores were stable in a follow-up 40 days after completion of the study, meaning that the results could be permanent even after the participants stopped taking the drug combination.

      upload_2018-7-17_12-22-42.png


      I am going to speak to my GP about this for sure!
       
      • Like Like x 1
      • Informative Informative x 1
    6. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      None of these studies target the actual volume of the T. The outcome measures are based on the typical THQ-type of questionnaires.
      Treatments that target the emotional response to T are actually available already (TRT, CBT, etc).

      It's good to have another option (especially a pharmaceutical one), but I wouldn't say it's "gold in our hands". The gold would have to be something that actually lowers the T volume, in my opinion.
       
    7. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      Yes they are (see my post above yours). They also used acufenometry in their measurements.
       
    8. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      Correct! I missed that! At least one of the studies does indeed cover that measured outcome and it does look good. I need to put this on my radar.
       
      • Like Like x 2
    9. Leon909
      Ape-like

      Leon909 Member

      Tinnitus Since:
      09/2015
      I bought three boxes of Aterina in Spain. Aterina is the brand name of sulodexide as its sold in Spain and you can get it without a prescription. It cost me about 45 €. I took 30g 2x per day. My dose was somewhat higher than the dose in one of the studies. I stayed on that dose for about 45 days.

      It didn't have any effects on my tinnitus. I didn't and don't notice any changes. I also didn't notice any longer adverse effects. On day 3 and 4 I had some pain in my hip area, but it went away after a day. Other than that no noticeable side effects.

      I did the THI questionnaire 3-4 times both before and during my treatment with Aterina. My THI score jumped around a lot. In fact it was also about 7-10 points lower during taking Aterina than before. However, I remember the first time I did the THI, I wasn't feeling very good on that particular day so that may have contributed to a higher THI score.
       
      • Like Like x 1
      • Informative Informative x 1
    10. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      You would have to take it with melatonin, as they did in the studies. Did you do that?
       
      • Informative Informative x 1
    11. Garye
      Thinking

      Garye Member

      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      ??
      I am going back to Chiang Mai Thailand in a few weeks (not specifically about Tinnitus,I have been there going long before my T started and lived there once).
      I will be there for 3 months. Sulodexide is available and apparently manufactured in Bangkok.

      If I am unable to purchase without prescription I am going to be armed with copies of the various reports and find a Thai doctor who will do it.The melatonin I will bring with me from Canada.
      I fully realize that it could very well not work...but seems worth a try while I am there.
      I am also going to try a massage specialist who has apparently worked with Tinnitus in Chiang Mai.
      Nothing ventured,nothing gained lol
      I will certainly update ,especially if I have some good news!
       
      • Like Like x 2
    12. Garye
      Thinking

      Garye Member

      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      ??
    13. Garye
      Thinking

      Garye Member

      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      ??
    14. noitseuq

      noitseuq Member

      Tinnitus Since:
      Right 2006. Left 2017
      Cause of Tinnitus:
      loud music
      how about melatonina? I think you we're supposed to use both.
       
      • Agree Agree x 1
    15. Garye
      Thinking

      Garye Member

      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      ??
      Agreed... the best results seem to be the combination,which is what I will try when I get there and have access to the sulodexide. BTW anyone here who finds themselves in that part of the world Sept Oct Nov 2018 I would be glad to meet up.Chiang Mai is a nice area..I know it well,speak some Thai.Cheers
       
    16. Dizzyhead888

      Dizzyhead888 Member Benefactor

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      unknown
      Has anyone tried Sulodexide? If so, what was your experience?

      I am considering trying it.
       

Share This Page

Loading...