The Association for Research in Otolaryngology (ARO) 2023 MidWinter Conference

Discussion in 'Research News' started by InNeedOfHelp, Nov 26, 2022.

    1. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      The largest research conference in Otolaryngology will take place on February 11-15, 2023: → the 46th Annual MidWinter Meeting of Association for Research in Otolaryngology (ARO).

      It is a 4-day event with a ton of new publications and results.

      I separately posted → some results of Acousia Therapeutics and → some research news of Ebselen but there is much more on hearing regeneration, hearing loss, tinnitus, and hyperacusis at this research conference.

      You can click on the day/time slot and then click on the presentation for more information/abstract. You can also find the results which are going to be presented. I'm not going to copy paste 100+ results but you are feel free to highlight here the ones that are important.
       
      • Informative Informative x 7
      • Like Like x 6
    2. Hazel
      Dreaming

      Hazel Director Staff Podcast Patron Benefactor Hall of Fame Advocate

      Location:
      the Netherlands
      Tinnitus Since:
      10/2017
      Cause of Tinnitus:
      one-sided hearing loss (of unknown origin)
      Thanks @InNeedOfHelp!

      Good news: We have just registered for the conference, I will be going there with one other volunteer. Please all take a look at the agenda and let us know which topics or speakers interest you in particular. We intend to do a lot of networking. And there will definitely be some form of reporting, just like we did with the Palm Springs Hearing Seminar, where Dr. Susan Shore recently presented some exciting preliminary results. Hopefully, we are also able to produce some video content/interviews!

      Us traveling there will of course come at a cost; I was particularly shocked by the cost of hotel rooms in Orlando! (Probably because the conference venue is right next to Sea World.) Any contributions to help cover the costs are very welcome!

      I very much look forward to representing this community at one of the most important conferences for tinnitus. For the very first time we will have an in-person presence there!

       
      • Winner Winner x 10
      • Like Like x 5
    3. Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      This is really great news. REALLY great. I will be making another small donation in January as I'm skint at the moment with Christmas and cost of living bullshit in the UK.
       
      • Like Like x 4
      • Hug Hug x 2
      • Winner Winner x 1
    4. Damocles
      No Mood

      Damocles Member Podcast Patron Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Otitis media
      AMM.jpg
       
      • Winner Winner x 5
      • Funny Funny x 2
      • Hug Hug x 1
    5. Hazel
      Dreaming

      Hazel Director Staff Podcast Patron Benefactor Hall of Fame Advocate

      Location:
      the Netherlands
      Tinnitus Since:
      10/2017
      Cause of Tinnitus:
      one-sided hearing loss (of unknown origin)
      We're busy preparing for the conference, and it's getting close now. I'm happy to report that @TuxedoCat, aka Linda, will be joining me at the conference. That's awesome, because there's so much to do: attending sessions, networking, recording interviews, etc. Thanks, Linda, for volunteering your time :)

      We've gone through the conference schedule and made a tentative plan for what to attend. Sometimes there are parallel sessions, so we have to choose one or the other. Also, the days are fully packed, from 8 AM to 8 PM with barely a break. All in all, this means we need to prioritise. We would love to hear which sessions you are curious about, let us know!

      From what we know, the BTA and ATA are not attending, so it looks like we'll be the only tinnitus patient organization there.

      Apart from attending the sessions, we've already made coffee/lunch appointments with Daniel Polley, Chris Cederroth, Will Sedley, and the folks from Hyperacusis Research. I will also be traveling to Washington DC to catch up with Josef Rauschecker. And I have an appointment in New York City with the CEO of Hearing Health Foundation.

      If there are people you feel we MUST interview on camera, let us know. We're there to represent YOU after all :)
       
      • Winner Winner x 14
      • Like Like x 2
      • Informative Informative x 1
      • Friendly Friendly x 1
    6. UKBloke
      Caffeine

      UKBloke Member Benefactor Hall of Fame

      Tinnitus Since:
      1991
      Cause of Tinnitus:
      Loud Music / family history
      Wow. Now that IS a turn up for the books. His 2011 paper massively influenced my own thinking about what tinnitus is and how it's generated.

      The idea of dysfunction in an upstream gating mechanism that essentially allows the tinnitus percept to 'leak' over into consciousness is the only explanation that's ever made sense to me.

      It certainly would explain why some people with hearing loss get tinnitus whilst others don't (I've never bought the 'hidden hearing loss' theory).

      Would love to hear Josef Rauschecker's current views on his 2011 paper and whether his perspective on it has changed. If you're able to get those views on camera, that would be a real scoop.
       
      • Agree x 6
      • Like x 2
      • Helpful x 1
      • Informative x 1
      • Useful x 1
    7. Fightthearmy

      Fightthearmy Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      work-related
      While any information on Josef Rauschecker's research is of high value, the most relevant for those with severe tinnitus might be near-term prospects such as deep brain stimulation.

      In your last interview with Dr. Rauschecker, the latter was unfamiliar with Dr. Shore's work. Wonder if that has changed.
       
      • Good Question Good Question x 4
    8. DimLeb

      DimLeb Member

      Tinnitus Since:
      03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy or Maybe Loud Music
      For a long time, I thought his theory made the most sense. But if you think about it, it falls apart with all those diseases that sort of "force" tinnitus as their symptom. For example, all patients with Meniere's, otosclerosis etc have some kind of tinnitus, so you would think that some of those people would have the stronger gating system that doesn't allow tinnitus to reach consciousness.

      Rauschecker's theory explains the cases of unknown origins, noise or stress induced, but it doesn't say anything about those other diseases. I have also learnt from around here and from a neuro-otologist I visit, that noise and stress can cause events like hydrops in the inner ear, so things get even more complicated.

      I agree, though, it's a huge thing to search why some people with hearing loss get tinnitus, while others (even with big or sudden losses) never get it.
       
      • Like Like x 1
      • Informative Informative x 1
    9. AUTHOR
      AUTHOR
      InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      I'd love to hear from Acousia Therapeutics. They are targeting KCNQ4 potassium channel cells in the inner ear for several forms of hearing damage, the latest press releases shows Q2 trial starting early 2023 so they are moving fast.
       
      • Like Like x 2
      • Agree Agree x 1
    10. Hazel
      Dreaming

      Hazel Director Staff Podcast Patron Benefactor Hall of Fame Advocate

      Location:
      the Netherlands
      Tinnitus Since:
      10/2017
      Cause of Tinnitus:
      one-sided hearing loss (of unknown origin)
      I don't think that topic is listed on the conference schedule?
      I think this session covers the gating theory, so that will be interesting to see.
      We covered them as part of our Palm Springs Hearing Seminar reporting, but as far as I could see they will not be present at ARO.

      Just a kind reminder that I'm looking for specific tips about who to meet/see at the ARO conference. You can use the search field at the top of the conference schedule (it's a very long schedule) to check for specific topics or people that interest you.
       
      • Like Like x 2
    11. AUTHOR
      AUTHOR
      InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      Hi Hazel,

      They are there. A bit tricky to find in the conference as they do not present under Acousia but under ACOU085.

      Hearing loss company Acousia Therapeutics to present data for lead candidates ACOU085 & ACOU082 at ARO 2023 MidWinter Meeting February 11–15

      Name of the poster presentation:

      SU141 Small-Molecule Kv7.4 Activator ACOU085 Protects from Cisplatin-Induced Hearing Loss and Outer Hair Cell Death in a Guinea Pig Model
       
      • Like Like x 3
    12. Hazel
      Dreaming

      Hazel Director Staff Podcast Patron Benefactor Hall of Fame Advocate

      Location:
      the Netherlands
      Tinnitus Since:
      10/2017
      Cause of Tinnitus:
      one-sided hearing loss (of unknown origin)
      Oh, right! Good find. We'll definitely go see the poster and hope to chat with them... Any particular question you'd like to ask?
       
      • Like Like x 1
    13. AUTHOR
      AUTHOR
      InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      Would be great to know if tinnitus is one of the indications of ACOU085 or ACOU082 and timeline for clinical trials. Both molecules are for noise/ototoxicity induced hearing damage with purposes of managing chronic hearing loss as well as future damage so very curious how they will look at tinnitus and if this will be a secondary endpoint in their clinical trials. Many thanks!

      If you talk to Jonathan Kil of Sound Pharmaceuticals, of course we are very curious what the anecdotal evidence is so far for SPI-1005/Ebselen for tinnitus and not just Meniere's disease, and what their timeline looks like for completion of Phase 3 and potential market submission.

      Dr. Susan Shore's 'team' is also there. Nothing specific to ask, any news is welcome, but I'm really interested how they interpret the results and if they are satisfied with the outcomes or if they were expecting more.

      Very nice that you travel there, I'm assuming that air travel/sound does not impact your tinnitus. Your itinerary seems noisy :)
       
      • Like Like x 3
      • Helpful Helpful x 1
      • Good Question Good Question x 1
    14. HopeForSilence
      Sad

      HopeForSilence Member Podcast Patron Benefactor

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      Explosion/noise
      First poster I'm interested in:
      Poster Session 1: SA225 Drug Discovery for Noise-Induced Tinnitus Based on the SBAD Model (Joseph Pinkl, McKenzie Rice, Jianxin Bao)

      Particular questions: What's the development stage of this treatment? Is there a timeline for upcoming milestones?

      Second poster I'm interested in:
      Podium #13 - Synapse and Auditory Nerve in Hidden Hearing Loss
      Transtympanic Delivery of Soluble Fractalkine Peptide Repairs Cochlear Synapses and Function After Acoustic Trauma (Vijayprakash Manickam, Andrew Stothert, Elyssa Pereyra, Lyudmila Batalkina, Tejbeer Kaur)

      Particular questions: What's the development stage of this treatment? What are the results from the transtympanic delivery of "Soluble Fractalkine Peptide"? Can you visualize the results? Is there a timeline for upcoming milestones?
       
      • Like Like x 4
      • Helpful Helpful x 1
      • Winner Winner x 1
    15. UKBloke
      Caffeine

      UKBloke Member Benefactor Hall of Fame

      Tinnitus Since:
      1991
      Cause of Tinnitus:
      Loud Music / family history
      Hi @Hazel, the above link didn't work my side. Anyhow, I've been to the site and searched for sessions specifically covering gating. Did you mean this one?: Link to PDF here.

      Looks like a fascinating study. I wasn't even aware University of Canterbury had been involved in this or are even ready to release interim data.
       

      Attached Files:

      • Like Like x 3
      • Helpful Helpful x 1
    16. Damocles
      No Mood

      Damocles Member Podcast Patron Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Otitis media
      pika.gif
      donation-to-tinnitus-talk.jpg

      ❤️️
       
      • Friendly x 5
      • Winner x 3
      • Agree x 2
      • Funny x 2
      • Like x 1
    17. Hazel
      Dreaming

      Hazel Director Staff Podcast Patron Benefactor Hall of Fame Advocate

      Location:
      the Netherlands
      Tinnitus Since:
      10/2017
      Cause of Tinnitus:
      one-sided hearing loss (of unknown origin)
      Thanks, that's it! Indeed seems like a fascinating study...
      Woohoo! How generous of you, @Damocles! We truly could not make this trip without such donations.

      I'm very excited to be going and representing you guys there. It's well worth sacrificing a week's worth of vacation days from my day job for.

      :huganimation:

      :thankyousign:
       
      • Winner Winner x 4
      • Like Like x 1
      • Agree Agree x 1
      • Friendly Friendly x 1
    18. Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      • Agree Agree x 4
      • Friendly Friendly x 4
    19. AUTHOR
      AUTHOR
      InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      @Hazel, if there is time, I think reaching out to AudioCure would also be very helpful. We don't have a thread on them yet here on the forums but they are working on an injection that targets to reverse hearing damage/regenerate synapses. It is currently in Phase 2 in Europe. It is very much under the radar. Pre-clinical studies showed almost complete reversal of acute hearing loss. It also targets acute tinnitus. They have EMA orphan drug designation. They will present Phase 1 data at the ARO. Perhaps some questions on timelines and outlook on specifically recovering from chronic vs. acute tinnitus?

      https://www.audiocure.com/newsroom/news-in-brief/

      The primary focus of AudioCure’s development program for AC102 is acute hearing loss and acute tinnitus. Currently there are no approved drug treatments available for these disorders. Our front-runner molecule has undergone comprehensive preclinical research which demonstrates that it acts upon the sensory cells and neurons with their connections that are central to the hearing process. As no other drug has shown any such action, AC102 has the potential to become the first breakthrough causative therapy (i.e. treatment aimed at eliminating the cause) for acute hearing loss and acute tinnitus. By treating these conditions as soon as possible after onset, it is our vision to prevent the development of long-term, chronic hearing impairments.

      How AC102 works
      In acute sensorineural hearing loss, the sensitive structures within the inner ear which are critical for the hearing process are damaged; namely the inner and outer hair cells and their synaptic connections to the auditory nerve. Preclinical studies have demonstrated the unique potential of AC102 to tackle the damage to these key players.​
       
      • Helpful Helpful x 1
    20. Nobody19

      Nobody19 Member Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing

      Attached Files:

      • Winner Winner x 2
      • Agree Agree x 1
      • Good Question Good Question x 1
      • Informative Informative x 1
    21. ZFire
      Tired

      ZFire Member Podcast Patron Benefactor Hall of Fame

      Tinnitus Since:
      2012 (mild) & 04/2021 (severe)
      Cause of Tinnitus:
      Ototoxicity (2012) Unknown-likely noise induce (2021)
      I can’t say I’m surprised, but it’s still embarrassing to see. Have they ever attended an ARO conference? You would think the bigger organizations for tinnitus would attend one of the largest and important research conferences for tinnitus...

      BTA/ATA feel like outdated organizations. There’s a stark contrast between them and what Tinnitus Hub does IMO, yet they get all the money.

      Nice donation btw, @Damocles.
       
      • Agree Agree x 9
      • Winner Winner x 2
      • Hug Hug x 1
Loading...

Share This Page