Tonic Zinc Inhibits Spontaneous Neuronal Firing in Dorsal Cochlear Nucleus Principal Neurons

Discussion in 'Research News' started by attheedgeofscience, Apr 4, 2015.

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    1. attheedgeofscience
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      attheedgeofscience Member Hall of Fame

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      http://www.ncbi.nlm.nih.gov/pubmed/25796568
       
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    2. jazz
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      jazz Member Benefactor

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      Thank you! Good information.

      Yes, this further supports his thesis on tinnitus induction.
       
    3. locoyeti
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      locoyeti Member Benefactor

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    4. valeri

      valeri Member Benefactor Team Awareness

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      Do we take zinc now to help t?
       
    5. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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      Tonic zinc? So liquid zinc?
       
    6. Sharpfire
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      Sharpfire Member

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      I am able to get access to the paper, I can message you the PDF if you wish.

      EDIT: Nvm just attached it instead. No idea why there's a water mark on it tho...
       

      Attached Files:

    7. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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      So what kind of zinc do we need?
       
    8. Sharpfire
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      Sharpfire Member

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      Not too sure what they mean by 'Tonic' but I think they're just talking about normal Zinc.

      Could be wrong but as far as I'm aware, the paper doesn't conclude that Zinc is able to reduce tinnitus, but that it is involved in some of the mechanisms behind it.
       
    9. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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      Very confusing, don't understand why they couldn't be clearer.
       
    10. ruben ruiz

      ruben ruiz Member

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      I believe it was meds and stress
      I thought Zinc was good for our conditions? Confusing is right!
       
    11. DebInAustralia

      DebInAustralia Member Benefactor Team Research

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      Tonic and phasic inhibition...think it relates to the manner in which zinc is released alongside glutamic acid...ie constantly (tonic) or intermittently (phasic)?
       
    12. DebInAustralia

      DebInAustralia Member Benefactor Team Research

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      I think ? (I think???) Zinc is an inhibitory neuromodulator...
       
    13. Lisa88

      Lisa88 Member

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      Thanks for this, ATEOS. I do believe that inhibition at the DCN of the auditory cortex may be key to reducing t.
      What form of Zinc is this zx1 chelate? i.e. What is the closest supplement available?
      Thanks.
      @jazz Just in case you have any ideas too? Cheers.
       
    14. Stink

      Stink Member

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      you didnt understand this study, debinaustralia did

       
    15. attheedgeofscience
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      attheedgeofscience Member Hall of Fame

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      I am afraid I have absolutely no opinion on such matters (the study in the article is an in vitro investigation after all). The best thing you can do is ask @Zimichael (who is part of Team Trobalt) and ask him to take it up with Prof. Tzounopoulos the next time they have a phone call (e.g. "What practical relevance might the findings in the paper have?").

      Team Trobalt is assisted in the background by (other) researchers who possibly could help with certain questions, but my 6th sense tells me that the paper has more theoretical than practical relevance (at this point), so-to-speak.
       
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    16. Lisa88

      Lisa88 Member

      Tinnitus Since:
      11/2013
      Yes. I understood it (read the full study). Not your odd comment.
      Excited re inhibition in the DCN with the zx1 applied.
      Just need to find practical application of the zx1, maybe in a specific zinc chelate or other form that we could all try.
       
    17. attheedgeofscience
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      attheedgeofscience Member Hall of Fame

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      See this:
      And now you know why I was reluctant to comment on the paper as I (correctly) anticipated the position of Prof. Tzounopoulos i.e. it would be silly of me to start making remarks - in public - on a theoretical paper that even the author himself is not willing to comment on (in terms of its practical "utility value", so to speak....).
       
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