Why the Hostility in the Research Section?

[MrCrybaby]

I notice a lot of negative posts in the research section of this site. Complaining about speed of studies/attacking scientists personally/doubting the products will work based on personal hunches and not data etc. But are we not the closest we have ever been to a potential treatment?

I suspect this is just a vocal minority, but I'm curious about what you all think. I'm honestly so grateful to be alive at this moment in history, where optimism is so easy to find in potential hearing and tinnitus treatments!

 

[all to gain]

We are a desperate bunch of people. Well, severe sufferers are. It may be much easier to be hopeful when your tinnitus is mild.

Maybe we are closer than ever to a potential treatment but until that treatment is on the shelves and is seen to work it means nothing.

I don't see the point of attacking researchers though. They owe us nothing.

 

[JohnAdams]

I notice a lot of negative posts in the research section of this site. Complaining about speed of studies/attacking scientists personally/doubting the products will work based on personal hunches and not data etc. But are we not the closest we have ever been to a potential treatment?

I suspect this is just a vocal minority, but I'm curious about what you all think. I'm honestly so grateful to be alive at this moment in history, where optimism is so easy to find in potential hearing and tinnitus treatments!

That Hough Ear pill is probably the best thing out there with a potential to heal noise induced tinnitus and it's just sitting on a damn shelf in a refrigerator. Gears aren't turning because of financial issues which is something that none of us should accept.

 

[FGG]

That Hough Ear pill is probably the best thing out there with a potential to heal noise induced tinnitus and it's just sitting on a damn shelf in a refrigerator. Gears aren't turning because of financial issues which is something that none of us should accept.

Maybe I'm missing something, but I don't see Hough having more potential than FX-322, PIPE-505 or OTO-413. It's nice that it's a pill, though.

 

[MrCrybaby]

We are a desperate bunch of people. Well, severe sufferers are. It may be much easier to be hopeful when your tinnitus is mild.

Maybe we are closer than ever to a potential treatment but until that treatment is on the shelves and is seen to work it means nothing.

I don't see the point of attacking researchers though. They owe us nothing.

I agree that it's easier easier for me to be optimistic with my now more mild tinnitus than when I constantly felt like molten metal was being poured into my ear.

It's true that it won't really matter until it's on shelf. I've seen lots of people being very doubtful in the face of promising trial results FX 322, Susan Shore's device, Hough pill) but I suppose this protects from the pain of disappointment? I also wish the Hough pill was here for me when I needed it to be fair...

I agree on the researcher front. I think it's pretty wild that there are people with, and even without, ear problems/tinnitus trying to help make our lives better.

 

[MrCrybaby]

That Hough Ear pill is probably the best thing out there with a potential to heal noise induced tinnitus and it's just sitting on a damn shelf in a refrigerator. Gears aren't turning because of financial issues which is something that none of us should accept.

I agree, but Hough doesn't have the money. Anger would better be channeled towards getting the military to fund it, or fundraising ourselves for it. They want to help us, it's not their fault financial plans fell through.

 

[JohnAdams]

Maybe I'm missing something, but I don't see Hough having more potential than FX-322, PIPE-505 or OTO-413. It's nice that it's a pill, though.

Well if the most vulnerable part of the system is the synapse between the SGN and the hair cell then regenerating that should do more right? What if the hair cell is intact and the problem is at the synapse?

 

[JohnAdams]

I agree, but Hough doesn't have the money. Anger would better be channeled towards getting the military to fund it, or fundraising ourselves for it. They want to help us, it's not their fault financial plans fell through.

The FDA needs to stop acting like mafia extortionists and make way.

 

[FGG]

Well if the most vulnerable part of the system is the synapse between the SGN and the hair cell then regenerating that should do more right? What if the hair cell is intact and the problem is at the synapse?

Both PIPE-505 and OTO-413 are for synaptopathy. PIPE-505 also helps with OHCs though.

 

[MrCrybaby]

The FDA needs to stop acting like mafia extortionists and make way.

The FDA regularly stops actual poison from being administered to the masses. We need them even though they're annoying. Other countries go even harder than the US when scrutinizing new medicines. It's the harsh reality.

 

[JohnAdams]

Both PIPE-505 and OTO-413 are for synaptopathy. PIPE-505 also helps with OHCs though.

The data from Hough Ear showed that their pill was superior to BDNF.

 

[FGG]

The data from Hough Ear showed that their pill was superior to BDNF.

Link to the comparison?

 

[JohnAdams]

The FDA regularly stops actual poison from being administered to the masses.

The chemical in the Hough Ear pill has passed safety tests in multiple trials for other things. So that is a really bad point to bring up here.

 

[all to gain]

The FDA regularly stops actual poison from being administered to the masses.

I consider anti-depressants and benzos poison. They make billions.

 

[JohnAdams]

Link to the comparison?

http://www.freepatentsonline.com/20180117115.pdf



My mistake. The comparison was BDNF vs BDNF + HPN-07.

 

[JohnAdams]

The FDA regularly stops actual poison from being administered to the masses.

Have you seen how many introductions there are on this website where the person got tinnitus from an FDA approved medication?

Are you just going to cry about negative vibes and play apologist for the toilet clogged system that is stopping us from being healed from this nasty condition?

 

[FGG]

View attachment 34387
http://www.freepatentsonline.com/20180117115.pdf

My mistake. The comparison was BDNF vs BDNF + HPN-07.

So they are using the pill with BDNF? That seems pretty relevant...

 

[GlennS]

Are you just going to cry about negative vibes and play apologist for the toilet clogged system that is stopping us from being healed from this nasty condition?

Start a petition or a political action committee or something if it means that much to you but whining about the FDA here and attacking other posters for not holding your same level of outrage is the equivalent to screaming in your pillow.

 

[JohnAdams]

@GlennS because complacent people like you infest this forum and actually fight against change. Disgusting.

 

[JohnAdams]

So they are using the pill with BDNF? That seems pretty relevant...

I don't think so. I believe that was just an experimental thing. I'm pretty sure the pill is HPN-07 + NAC.

 

[GlennS]

@GlennS because complacent people like you infest this forum and actually fight against change. Disgusting.

Where exactly are you fighting the good fight, John? All I see you doing is dumping your anger into your keyboard and having it spill over into attacking other T sufferers. It ain't makin' the world a better place, man.

 

[FGG]

I don't think so. I believe that was just an experimental thing. I'm pretty sure the pill is HPN-07 + NAC.

But does their data show what happens without the BDNF? Either way, that bodes well for OTO-413 being helpful. Either on its own or with HPN-07/NAC

 

[JohnAdams]

@GlennS who did I attack? Give one example where the person hasn't attacked me first.

 

[JohnAdams]

But does their data show what happens without the BDNF? Either way, that bodes well for OTO-413 being helpful. Either on its own or with HPN-07/NAC

OTO-413 will need to be injected into the middle ear and very little will make it to the cochlea and it will certainly require multiple injections. Regardless, I think this is something that should also be accelerated and approved. It is safe. I know this for a fact.

 

[JohnAdams]

But does their data show what happens without the BDNF?

I'll have to recheck but I don't think so.

 

[FGG]

OTO-413 will need to be injected into the middle ear and very little will make it to the cochlea and it will certainly require multiple injections. Regardless, I think this is something that should also be accelerated and approved. It is safe. I know this for a fact.

Why will very little make it to the cochlea?

Otonomy's intratympanic drugs are vehicled in a surfactant that should make it to the apex of the cochlea. Fun fact: pipeline also uses the same surfactant (at least that's what is listed on their patent) and Pipeline confirmed to me via email that their drug diffused across the entire cochlea.

 

[HootOwl]

OTO-413 will need to be injected into the middle ear and very little will make it to the cochlea and it will certainly require multiple injections. Regardless, I think this is something that should also be accelerated and approved. It is safe. I know this for a fact.

OTO-413 is being formulated by the same company that has pioneered Menieres drugs. These drugs HAVE to reach the apex of the cochlea in therapeutic doses to be effective. They even patented a single injection-slow release method using their own vehicle (I can't recall the surfactant's name off hand) that guarantees as such.

I think you're severely underestimating what Otonomy can accomplish with regards to cochlear penetrance.

 

[MrCrybaby]

I consider anti-depressants and benzos poison. They make billions.

That's a fair point.

 

[FGG]

OTO-413 is being formulated by the same company that has pioneered Menieres drugs. These drugs HAVE to reach the apex of the cochlea in therapeutic doses to be effective. They even patented a single injection-slow release method using their own vehicle (I can't recall the surfactant's name off hand) that guarantees as such.

I think you're severely underestimating what Otonomy can accomplish with regards to cochlear penetrance.

I'm not sure Ovi-dex is supposed to help Meniere's hearing loss (Apex) but it would still have to diffuse far (well into the inner ear) to reach the relevant vestibular structures.

Either way, I got an email confirmation that Pipeline's drug reaches the entire cochlea to the apex after IT injection and both Otonomy and Pipeline use poloxamer 407 in their vehicle. Hopefully, Frequency will do something similar eventually.

 

[JohnAdams]

Why will very little make it to the cochlea?

Round window membrane.

vehicled in a surfactant that should make it to the apex of the cochlea

That's good news. I didn't know that. Surfactants are hydrophobic right?