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The trial with Huperzine A is for people with presbycusis and tinnitus. People that have already tried Huperzine A do not get the full effect because their tinnitus is part of a dysfunctional brain. Is this a correct theory?

I just orderd this one. I have presbycusis and tinnitus. Please god, let this be the one.

Efficacy and safety of single and repeated selurampanel dosing for 2 weeks in patients with chronic subjective tinnitus Abstract To evaluate efficacy and safety of BGG492 (selurampanel; an orally active, competitive AMPA glutamate receptor antagonist) in patients with moderate-to-catastrophic...

This article is in Dutch but it says that Lenire is now available at the Brai3n clinic in Belgium. Tongstimulatie voor de behandeling van tinnitus

What happened to RL-81 made by SciFluor Life Sciences? Their website is offline... Is this again a dead end for a hopeful tinnitus treatment?

Impact of Acamprosate on Chronic Tinnitus: A Randomized-Controlled Trial Objectives: Tinnitus is a common and distressing otologic symptom, with various probable pathophysiologic mechanisms, such as an imbalance between excitatory and inhibitory mechanisms. Acamprosate, generally used to treat...

Interesting. Has anyone got any experience with Gliatilin here on Tinnitus Talk? The results of treatment of 38 patients suffering from sensorineural hearing loss with the Gliatilin (solution 3 ml intravenously for 10 days, capsules 400 mg 3 times a day or solution for ingestion 600 mg 2 times...

Today (9th January 2020), the charity Action on Hearing Loss and Medicines Discovery Catapult announce the launch of the Hearing Medicines Discovery Syndicate, a unique collaboration to accelerate the much-needed development of treatments for hearing loss and tinnitus. Hearing loss affects...

A proof-of-principle study of the short-term effects of MDMA (3,4-methylenedioxymethamphetamine) on tinnitus and neural connectivity. BACKGROUND: This study was conducted to investigate the short-term behavioral and neurophysiological effects of MDMA (3,4-methylenedioxymethamphetamine) on...

Abstract INTRODUCTION: Tinnitus is defined as the perception of sound without its actual presence in the environment. It has been the subject of a great number of studies, especially considering its consequences on patient's quality of life. OBJECTIVE: This study aimed to investigate the effect...

Auris Medical Provides Update on Tinnitus Drug Development Strategy April 25, 2019 at 9:00 AM EDT Hamilton, Bermuda, April 25, 2019 (GLOBE NEWSWIRE) -- Auris Medical Holding Ltd. (NASDAQ: EARS), a clinical-stage company dedicated to developing therapeutics that address important unmet medical...

I looked at the MuteButton's website today and I noticed the following sentence. Neuromod’s CE-marked medical device comprises of three main components Is this something I missed?

Association of Chocolate Consumption with Hearing Loss and Tinnitus in Middle-Aged People Based on the Korean National Health and Nutrition Examination Survey 2012⁻2013. Abstract Chocolate, which is produced from cocoa, exerts antioxidant and anti-inflammatory effects that ameliorate...

Prof. Hubert Lim Chief Scientific Officer presenting TENT-A1 (326-patient) 12-month post-treatment follow-up data and TENT-A2 (192-patient) confirmatory efficacy data. https://www.amauditorysoc.org/program

The new Trobalt is XEN-1101 and it is almost in phase II. https://www.xenon-pharma.com/product-pipeline/xen1101-for-epilepsy/

But ... are there members here that can confirm that Co-Q10 was helpful?

Water-Soluble Coenzyme Q10 in Chronic Hearing Loss https://doi.org/10.1177/0194599811416318a202 Abstract Objective: Q-TER is a multicomposite water-soluble formulation of CoQ10; in particular, Q-TER consists of a mixture of maltodextrin, acting as a carrier, of CoQ10 molecules of sucrester...

Let's find this guy... Hear from clinical trial volunteer Hugh, who noticed a significant reduction in tinnitus volume after 6 weeks of using Neuromod's bimodal neuromodulation treatment device for tinnitus.

Neuromod Appoints Leading Tinnitus Expert Professor Richard S. Tyler, PhD to its Clinical Advisory Board November 26, 2018 07:00 AM Eastern Standard Time DUBLIN--(BUSINESS WIRE)--Neuromod Devices Limited (“Neuromod”), an Irish medical technology company specialising in non-invasive...

A big no.

http://www.sensorion-pharma.com/images/press-release/20181107-PR-Sensorion_Neurocience_2018_EN.pdf

http://investors.otonomy.com/news-releases/news-release-details/otonomy-presents-data-highlighting-potential-oto-413-otic Press Release Otonomy Presents Data Highlighting Potential of OTO-413, an Otic Sustained-Exposure Formulation of BDNF, to Treat Hearing Loss Society for Neuroscience...

Adapted Acoustic CR Neuromodulation in Patients With Chronic Tonal Tinnitus and Hearing Loss. Chronic tonal tinnitus is often accompanied by sensorineural hearing loss which is associated with altered tuning curves and bandwidth of alternating masking. In this feasibility study the so-called...

Curcumin Reduces the Noise-Exposed Cochlear Fibroblasts Apoptosis Conclusion Curcumin proved to be potentially effective in the prevention and treatment for fibroblasts damage within the cochlear supporting tissues and lateral wall regarding the decreased expression of calcineurin, NFATc1, and...

Totally Implantable Active Middle Ear Implant: Hearing and Safety Results in a Large Series

xen1101 is moving to phase II http://investor.xenon-pharma.com/phoenix.zhtml?c=253202&p=irol-newsArticle&ID=2362563

An abnormal brain activity pattern could be a common link between Parkinson’s disease, neuropathic pain, tinnitus, and depression, an international research team suggests. The brainwave abnormality is similar in all these disorders but occurs in different regions of the brain. This discovery...

Why is it so quiet on this thread? There are multiple independent studies with positive outcomes. Maybe we have gold in hour hands...! Unfortunately it's not available in my country. Maybe I can buy it somewhere! Sulodexide Monotherapy in Chronic Idiopathic Subjective Tinnitus: A Randomized...

Maybe a stupid question but I can't find the answer! I know that NAC can prevent tinnitus after loud noise but can NAC also help if you had tinnitus for years?

This company is still active and will present the Aurex-3 soon. http://www.digitaljournal.com/pr/3814820

Green Tea Extract Linked to Tinnitus Having a cup of piping hot green tea feels good for the body as well as the soul. But new evidence suggests that we should moderate our intake of the powerful antioxidants found in green tea. Green tea extract, which is found mostly in supplements...

Maybe an old publication https://www.ncbi.nlm.nih.gov/pubmed/21162656 But has someone ever given this a shot? It looks like well done research. Is water-soluble coenzyme Q10 the same as the Q10 that you can buy online?

Connecting hearing helper molecules to the ear bone “Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss” Bioconjugate Chemistry Hearing loss is a common affliction associated with advancing age and exposure to...

see this thread https://www.tinnitustalk.com/threads/tolperisone-sleep-and-muscle-relaxant-non-ototoxic-works-well.18805/

Received mail from Auris about post acute tinnitus. Thank you for your inquiry. We have seen some evidence that Keyzilen may work in a post-acute setting (3-6 months from onset, potentially more). It should be noted that the 3 or 6 month definitions of acute/chronic are to some extent “lines...

Neuromod hires research expert in move to bring tinnitus device to market Irish medtech start-up seeking to commercialise non-invasive device for condition Dr Hubert Lim, who has joined Neuromod as chief scientific officer, is a researcher at the cutting edge of auditory neuroscience...

Is Am-101 only for acute tinnitus ? Or can it be helpful for chronic Tinnitus after 6 months ?

Does melatonin actually lower tinnitus in volume because it reduces firing neurons or does it work because people sleep better and deeper?

Positive outcomes for the Tinnitus patch ..... http://www.tinnitusjournal.com/articles/a-randomized-placebocontrolled-doubleblind-parallel-groups-study-evaluating-the-performance-and-safety-of-a-steady-state-coherent.pdf

Anyone quits smoking and see his T goths lower ?

Baclofen is almost the same as phenibut. It binds to gaba-b. Phenibut is a otc supplement without serious side effects!

Abstract The auditory temporal processing deficits associated with age-dependent hearing decline have been increasingly attributed to issues beyond peripheral hearing loss. Age-related hearing loss (ARHL), also known as presbycusis, is linked with changes in the expression of both excitatory and...

Browsing the internet I came across this... Can it be helpful for Tinnitus? Mechanism of action[edit] The mechanism by which minoxidil promotes hair growth is not fully understood. Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes. Hypothetically, by widening...

Otoharmonics, developers of the Levo Tinnitus System, has reached an exclusive agreement with Elite Hearing Network—a network of independent hearing care providers that is part of Amplifon USA—to provide the Levo System to its 1,600+ network members, the companies jointly announced. Levo System...

I asked them when the device becomes available. Today I received an answer. Dear, Many thanks for contacting us. At the moment we have paused sales of mutebutton until further notice. The reason being that we are dedicating most of our resources into preparing the mutebutton technology...

Comparison of Melatonin and Sertraline Therapies on Tinnitus: A Randomized Clinical Trial. Abstract BACKGROUND: Tinnitus is the perception of noise or ringing without external acoustic stimulants which affects almost 10% of general population. Many therapies have been recommended including...

Green tea effects on cognition, mood and human brain function: A systematic review. Abstract BACKGROUND: Green tea (Camellia sinensis) is a beverage consumed for thousands of years. Numerous claims about the benefits of its consumption were stated and investigated. As green tea is experiencing...

Interesting herb. Anyone tried it???

Are there people here on the forum that have tried oxytocin? And not the homeopathic stuff but a prescription!

If I go to the doctor will he prescribe me a prescription so I can be a test person?

What's the difference between noise-induced tinnitus and tinnitus due to age related hearing loss? Or is it just the same?

Objectives In tinnitus rTMS treatment, the inhibitory 1 Hz stimulation is commonly delivered to left auditory cortex and/or left temporoparietal junction (TPJ). We aimed to improve rTMS-targeting with fMRI measurements. Methods A patient with whiplash and head trauma originated brain injury...

Hi people, I found this on the web. http://www.audiologyonline.com/articles/treatment-tinnitus-using-customized-ultrasonic-18261 Results: Highly significant reduction in tinnitus loudness and annoyance was observed in all subjects during exposure to a customized acoustic stimulus delivered...

The REV33 dramatically reduces the symptoms of tinnitus, ear-ringing, ear-fatigue, buzzing and dampened hearing by preventing in-ear monitors and headphones from producing this unwanted noise and distortion. http://rev33.com/

I know that Siemens hearing aid has an option for notch therapy. Has someone on this forum tried this?

Here is my theory about dopamine: Sulpiride is an dopamine angonist. It lowers your level of dopamine. https://www.ncbi.nlm.nih.gov/pubmed/17942035 Pramipexole is a dopamine agonist. It raises your dopamine level. https://www.ncbi.nlm.nih.gov/pubmed/?term=pramipexole+tinnitus Aripiprazole is...

INTRODUCTION: One of the treatments currently available for the remission of tinnitus, when associated with hearing loss is the use of hearing aids with sound generator. Such treatment is based on the capability that the human brain has to get used to a new sound over another. OBJECTIVE: To...

I smoke almost for 20 years. Four years ago my ears starts hissing. I went to the doctor and noticed a hearing loss of 60 dB ! If I stop smoking is it possible that my tinnitus goes on a holiday!? My dad and his dad has also hearing loss but no tinnitus!

Can you buy this stuff? Is it for T?

Anyone has experience with this ? It looks good but very expensive !! https://www.connecthearing.com.au/en/invisible-hearing-aids/lyric-tinnitus/