Biological Sciences Have a Long Way to Go and Need to Be Taken More Seriously

Discussion in 'General Chat' started by Contrast, May 3, 2020.

    1. Contrast
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      Contrast Member Benefactor Hall of Fame

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      noise injury
      I don't understand why the biological sciences are not given more priority, funding, appreciation and recognition. Why is biology not taken seriously? The technological sciences are way more ahead, considering we have computers, and smartphones. But we can't regrow the damaged cells in our body!

      Poster is not me, but basically ask the question I want to know.

      https://www.quora.com/Why-is-the-medical-progress-very-slow-compared-to-technology

      Below I just want to show examples of what biomedical sciences can do, and the promise they hold.


      Up and Coming Treatments for Peripheral Neuropathy

      https://www.kqed.org/science/1207350/rudolphs-antlers-could-help-restore-mobility-in-injured-humans

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      Up and Coming Treatments for Hearing Loss (Dr. Liberman's research)

      https://www.entandaudiologynews.com...-conversation-with-professor-charles-liberman

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      Up and Coming Treatment for Heart Disease

      http://www.oprah.com/health/stem-cell-research-on-heart-disease

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      I just wanted to point out I am literally friends on the Internet with other people who are suffering and in "total shit" condition physically. Whether it be tinnitus, hearing loss, noxacusis, fibromyalgia, nerve pain, heart disease, sexual dysfunction, rheumatoid arthritis, auto immune disorders. Basically these people are suffering like slaves just because of bad biology. It's like an innocent good person gets a prison sentence. They have the most unforgiving lives that they don't deserve. It's heart breaking.

      -

      I'm surprised how many parallels exist with "it's all in your head" and CBT/ACT/opioids flowchart treatments I've heard. As well as people who get denied disability multiple times. yatta yatta. Hidden Hearing loss and small fiber neuropathy are two examples of "illusive problems" that go diagnosed.


      Here's an example...


      Hidden Hearing Loss

      https://www.wsj.com/articles/cant-hear-in-noisy-places-its-a-real-medical-condition-1474909624

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      Small Fiber Neuropathy

      https://www.health.harvard.edu/diseases-and-conditions/new-thinking-on-peripheral-neuropathy

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      I've drawn to the conclusion that biological sciences are very far behind and this is simply a "too early" part of human history. Hopefully the future (which is what we choose) will be better. Well because this part of human history is pathetic. A world without biological sciences to save the day, is a bad world indeed.

      https://oklahoman.com/article/5560970/oklahoma-discovery-could-restore-hearing-with-a-pill
      Imagine walking in the clinic with tinnitus and walking out with new cochlear synaptic connections. That will be the day.

      -contrast
       
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    2. Bill Bauer
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      Bill Bauer Member Hall of Fame

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      Ideally the additional benefit as a result of the last dollar spent on a project has to be equal across all of one's projects. If that wasn't the case, it would be possible to increase the total benefit by moving the money from the project for which this value is the lowest to the project for which this value is the highest.

      What we are observing might be the result of biology projects being inherently expensive (as a result of the incredible complexity of biological systems), implying that even though each of those biology projects has a high total benefit, the cost is also high. Alternatively, it could be that the venture capitalists, angel investors, and government agencies in charge of allocating funds make decisions based on politics instead of relying on the sound cost-benefit analysis.
       
    3. Jazzer

      Jazzer Member Benefactor Hall of Fame

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      As nobody has found the answer, perhaps this predicament is insoluble.
      Success would generate billions.
      The prize is guaranteed.
       
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    4. FGG
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      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      I think, in the past, not centralizing and pooling research has also been a huge obstacle and research had to be even duplicated at times.

      Effective computer modeling and even AI is allowing huge strides in research now and can circumvent some of that. Before that, it was an almost insurmountable trial and error, but now simulations can play through compounds more easily and scientists have an idea what drugs will bind to the structures they need and how.

      If you look at the drugs coming out in the last few years, you can already start to see they are paradigm changers and not just "building a better mousetrap." For example: exon skipping drugs.
       
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    5. FGG
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      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      You don't just "find the answer", you build on existing research in a step like pattern until you find it. Take Frequency Therapeutics for example, the concept of progenitor cell activation had to be learned in the intestine mucosa first (which can fully regenerate in about a week) before it could be applied to the cochlea. But more generally, it wasn't until they discovered that birds and even neonatal mice to some degree do this naturally that they found out how feasible this was in people. You can't skip the "discovery" phase though and that takes time.

      It's like trying to invent the internet before the computer chip or even electricity. It doesn't happen that way.
       
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    6. MrCrybaby

      MrCrybaby Member Benefactor

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      There will need to be a major paradigm shift in patients. Right now a lot of pseudoscience can be found mainstream treatments, from TRT to orthodontics to chiropractics, there are so many “treatment options” that range from useless to harmful. Patients will need to learn to expect real solutions to their problems and not treatments based solely on ideology.
       
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    7. PeteJ
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      PeteJ Member

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      As long as morons aka humans are fucking stupid, selfish and self-centered, they vote for assholes and garbage who won't do anything to help people. Keep voting for liberal puppets and neocons, idiots.
       
    8. AUTHOR
      AUTHOR
      Contrast
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      Contrast Member Benefactor Hall of Fame

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    9. MrCrybaby

      MrCrybaby Member Benefactor

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    10. AUTHOR
      AUTHOR
      Contrast
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      Contrast Member Benefactor Hall of Fame

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      There needs to be a way for patients to influence the NIH directly. I know someone with a horrible niche form of neuropathy that literally called the NIH. He told it "it was very difficult to get in touch with the right people" He's seen all the doctors in the world and got no where.

      unreal. Honestly how many times I heard this. This part of human history sucks.
       
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    11. Tybs

      Tybs Member

      Tinnitus Since:
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      Fall from stairs
      The comparison between technological and biological research is not completely fair when we consider measurement: meaning the capability to measure data objectively.

      With computers, we can put sensors on every datastream we want. All the data can be read and translated into whatever kind of information we need. When it comes to the human body, we cannot get to this level of detail. Sure, measuring a pulse is possible, and we can use scans to see some brain activity: but we have no way of following every "bit" of data that is sent throughout the body. We cannot "select" a toe as source, and read all the signals that are send from this body part to the brain. All we can do is form a hypothesis and experiment on a bunch of people: a method that can bear fruit, but it is never truly objective. Incorrect conclusions occur quite often.

      Data equals knowledge here. I'm convinced that once the body can be measured with the described level of detail, every chronic illness could be resolved in a matter of years.
       
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    12. AUTHOR
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      Contrast
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      Contrast Member Benefactor Hall of Fame

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      Cause of Tinnitus:
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    13. AUTHOR
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      Contrast
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      Contrast Member Benefactor Hall of Fame

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    14. serendipity1996

      serendipity1996 Member Podcast Patron

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    15. AUTHOR
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      Contrast
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      Contrast Member Benefactor Hall of Fame

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      Growing human organs inside pigs (or potentially primates) could be something extremely promising in the future for diseases relating to organ failure. They have along way to go, this science is in it's infancy. But biologist do all sorts of amazing things that can change the quality of lives for millions of people


      They fuse the egg cell of the pig with certain cells from a human body during a very early window.

      https://www.statnews.com/2017/10/20/human-pig-chimera/



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    16. FGG
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      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      They have come even further since 2017:

      https://edition.cnn.com/2020/05/21/us/human-mouse-chimera-hybrid-scn-trnd/index.html

      Wish they would work on a translatable cochlea when they improve this but I know that is far off for now. If you even look up "cochlear transplant" all you get is info on CIs and that's so not equivalent.
       
    17. Greg Sacramento

      Greg Sacramento Member Benefactor Hall of Fame

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      I also think very much so.
      For those over 60:
      Neuro, heart and vascular diseases don't get discovered soon enough. Someone older could have just one hypertensive event that lasts only a few seconds where a stroke or heart attack doesn't happen, but all kinds of serious damage can happen. For those older who just don't feel right, I think that they should be given ultrasounds of their entire body as well as a chest X Ray, heart ECHO and complete blood work. With those older, the carotid receives noticeable signals from troubled organs and from blood flow distress from anywhere in the body including the toes.
       
    18. AUTHOR
      AUTHOR
      Contrast
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      Contrast Member Benefactor Hall of Fame

      Location:
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      Cause of Tinnitus:
      noise injury
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