Decibel Therapeutics

So, what have they actually accomplished since 10/15? A whole bunch of BS. Why do I feel like 10 years from now they will still be talking about new members of their ‘leadership Team’ Lol

 

I'm not gonna let you shit on DB-tx, other then rock climbing being cool, there co-founder Charles Liberman who made most of the discoveries centric to hidden hearing loss and noise induced pain and regenerative medicine for the cochlea!

If it wasn't for his research we'd still be wandering in the world of tonal audiometry and audiologist lying to us that burning ear pain from noise meant "amazing hearing" and cures being 100 years away.

 

Has he even started any trials...?

 

Charles Liberman is great but unfortunately we are still very much in that world. It's gonna take a lot more to get audiology to exit the Middle Ages.

 

That's where MPP comes in.

 

Melrose Place Police? Say what?

 

https://www.decibeltx.com/decibel-t...or-research-in-otolaryngology-aro-conference/

Lots of mice stuff.

 

New!

Pharmaceutical Treatments for Hearing Loss, a Brief Q&A with Michael Su, Ph.D., CSO of Decibel Therapeutics

 

To get an idea of Decibel Therapeutics' work, here is an example of Charles Liberman's research on "noise induced pain"

https://hyperacusisresearch.org/2016-aro-symposium-pain-hyperacusis/

 

Dude. So what have they done to help your tinnitus? Absolutely nothing my friend. Don’t believe all the BS empty promises.

 

They are starting a trial for cochlear synaptopathy.

 

I'm pretty sure the rock climbing post was another jab at decibel..... When they first came out a lot of us got excited, but at this point they dont even have a trial for hearing loss planned. There is a lot of good research out there and a lot of hopeful articles for different approaches on regenerating hearing loss. Maybe they looked into all of them and they turned out to be duds. Who knows... Either way, it would be nice to see some progress from them. Right now frequency is the best bet and hopefully they start phase 2 trials soon. There are many people that are suffering or on the verge of getting cochlear implants, myself included, and timing is very important.

 

Frequency Therapeutics' drug might help with those synapses. I saw that somewhere but don’t ask me to find it. You might have even posted it for all I know.

Decibel Therapeutics are going the gene therapy route, right? I saw another company on YouTube is also doing the same thing but I believe they have a drug already and it boosts a growth factor that is responsible for neuron creation and maintenance.

 

I do not know, but based on Liberman's research I believe the hearing restoration drug uses neurotrophic-3.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842978/

 

I think there might be more info here:
https://patents.google.com/patent/US20190022101A1/en

Seems to mainly be for acute hearing loss, if I interpreted the charts correctly (and if this is the same thing?)

 

That's the thing, I don't know either. When Liberman said months, years to decades to describe the therapeutic window of Spiral ganglion neurons surviving and being able to send out a new synaptic connection is very promising.

Is the NT-3 treatment for acute neuropathy SNHL, and his statement above a hypothetical idea for treating chronic neuropathy SNHL?

 

Sorry for spreading fake news. I read it in more detail, and this is definitely not just for acute hearing loss.

Maybe it will be there in time to fix our ears. I guess nobody knows...

 

Glad they are rock climbing while our therapeutic window narrows.

 

Do you just have hyperacusis or do you also have tinnitus but with no measured hearing loss? I have a friend with just hyperacusis that causes her pain. She doesn’t really know what’s wrong with her and I think maybe if you have something similar you could shed some light on the possible cause.

 

I know the direct cause, it is blatantly obvous. I had a history of loud music, headphones ever since I was in middle school I always was using loud headphones regularly and had experienced rare tinnitus, and in later 2017 an intentional horribly loud acoustical shock due to my own stupidity. Two separate ENT visits declared me to have perfect hearing via tonal audiometry.

In my right ear I have I have difficulty distinguishing low pitch notes in background noise, difficulty hearing typical male voice in background noise. High pitches sound dull but remember the doctors told me I had perfect hearing.

In my right ear most higher pitch noises cause my jaw and nose to feel a slight numbness. This use to be a lot worse the first two months I had chronic burning in my neck and jaw, following later continuation of burning pain from noise that latest 8 months or so but that went away. Whatever form of "hyperacusis" this is left is uncertain I suspect it has to do with the trigeminal nerve, I am also confused on where this adds up with research about cochlear nociception and OHC nerves that send pain signals.

 

I thought I posted this early, I apologize for not being able to refute John's ignorant comment quick enough.
https://www.decibeltx.com/decibel-t...or-research-in-otolaryngology-aro-conference/

@Autumnly

 

You can buy it online.

I wonder who is going to try it first on this forum without waiting for trials and release of the drug itself.

 

Have you made up your mind on where to buy it?

I've seen BDNF and IGF-1 too online, but it seems that it's for "research purposes only".
I wonder what kind of risks are there?
It's not like it can cause damage or anything. At least I don't think it so.

I know an ENT who can inject whatever I'd like, but he doesn't recommend injecting PRP intratympanic, because there is a certain risk.

So I'm thinking of buying some growth factors online, because there's no risk that PRP has.

 

I don't even know if it will work because Liberman's research seems to state it only works in an acute window, and it could be that Decibel's drug will be NT3 + something else that extends the therapeutic window.

The biggest problem I'm facing is I will have no one to do the injection.

 

I think it’s only for acute window I searched it up and it says it works within 24 hours... but who knows...

 

I’ll do it for you.

 

Whatever risks there are are very low.

 

Yes, but Professor Liberman mentioned the survival of spiral ganglion neurons being possibly decades and theories to get them to send out new synapses. TBH I don't understand but Decibel and Otonomy wouldn't be launching trials just for an obscure 24 hour window, the general public would not know to even visit an ENT within 24 hours.