Decibel Therapeutics

Discussion in 'Research News' started by Contrast, Jan 9, 2019.

    1. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      You will not find a doctor that will inject you with synthetic IGF-1.
       
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    2. Arseny
      Wishful

      Arseny Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Possibly from problems with blood flow
      You need to ask them one by one. No one will agree to do it publicly.
      Even in Russia no clinic will agree for anything that's not regulated, but if you ask nicely you can do pretty much anything as long as you sign the waiver.

      I don't think there's a secret ingredient and these drugs are at least 1-2 years away from market. You have more chances on recovery if you do it now vs 2 years later.
       
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    3. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Contrast. I like your thinking, a brilliant idea really. Have you run this by any medical professionals, otologists, ENTs? A bloody good idea, I'm sure the Shim meister would do it in a heart beat. And he is skilled. Cheaper is better, myself and my family just scrape by, and there ain't nothing left over. To drum up 16 to 18 grand, even the 9, that John Adams paid to Shim is a big ask.

      If you're serious, I will run it by a kick ass ENT I met in Thailand recently, another story there.

      Tell me what to ask, if you're serious, you know a hell of a lot more than me.

      Honestly, over here in Bangkok Thailand state of the art hospitals are cheap. It's nuts.

      Let me know, I feel the window is closing, and that is not cool for us, all of us.
       
    4. AUTHOR
      AUTHOR
      Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      When Decibel Therapeutics updated their website a few weeks ago, it broke all the links. Everything is fixed now. (y)
       
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    5. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      "Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure"

      https://www.nature.com/articles/srep24907

      Good luck!
       
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    6. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      upload_2019-3-4_16-59-7.png
      Glad we're at the bottom of this list. Why can't multiple companies be working on each of these things instead of one company slowly going one at a time? If they have a clue how to treat this then why would there be any delay whatsoever?
       
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    7. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      DT,

      Where art thou?
       
      • Good Question Good Question x 1
    8. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Yes Flamingo1, so much potential and genius, where art thou Decibel Therapeutics?

      Brain damage is a drag, this is one of the companies with some of the best brains for our condition. It's like a bad existential paradigm of waiting for a god or mythic savior that doesn't exist or come...

      Oh my beloved DT, please come and grace us with your medical marvels...

      Sincerely Daniel and the rest of us here.
       
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    9. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      Correction: With your promised medical marvels
       
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    10. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      Bumping this thread. Anybody hear anything from Decibel besides how much money they spent on new headquarters and their rock climbing adventures?
       
      • Good Question Good Question x 5
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    11. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Why the hell can't they test these drugs faster?
       
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    12. Simon Czt

      Simon Czt Member

      Location:
      France
      Tinnitus Since:
      06/2018
      Cause of Tinnitus:
      Acoustic trauma
      Where did you find the graph you posted above a few months ago?
       
    13. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      • Informative Informative x 3
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    14. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      Is it just me or did they go backwards. This company is a waste. They have incorrect priorities. At this point I only hope they don't clog up the research feed touting how much money they've received from investors.
       
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    15. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      I'm confused as well. I had high hopes for these guys. It doesn't seem like they have anything even close to phase 1 for hearing loss.
       
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    16. AUTHOR
      AUTHOR
      Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      They are playing it safe with anti-ototoxic drugs before they move on to the regenerative fantasy stuff. If they stick to simpler task like rushing anti-ototoxic agents for cancer patients, they'll get success which means more funding for research. They need to learn more about hidden hearing loss, noxacusis and the inner ear before they put out a therapeutics for it.

      We aren't first on their list because we are more difficult to treat and they don't want to blow it.
       
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    17. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      upload_2019-8-20_10-28-7.jpeg

      Definitely playing it loose.
       
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    18. Auron
      Dead

      Auron Member

      Location:
      Planet Earth
      Tinnitus Since:
      Spring
      Cause of Tinnitus:
      Acoustic Shock
      So any Decibel Therapeutics news anyone?
       
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    19. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I just noticed from this latest graph that their auditory neuropathy/tinnitus drug in pre-clinical says it's a biologic. This seems like a really different approach and i am very curious about it.
       
    20. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      I just Google them Nothing since February of this year. I'm sorry, but this company seems like a scam. I mean with all those important and renown researchers tied to the company, nothing?? No papers, no plans for clinical drug testing?
       
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    21. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      It's probably BDNF.
       
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    22. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I was just assuming it would be something so far untried since Otonomy has BDNF covered. Maybe like NT-3?

      There must be something (not BDNF) that they found that shows (or also shows) promise in addressing synaptopathy and tinnitus.
       
      • Agree Agree x 1
    23. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Yeah or NT3 thats a biologic.
       
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    24. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      Yep. I posted about this back in early June 2018. I would/should have shorted this company then if I knew how to do that.
       
    25. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      Decibel Therapeutics is not a publicly traded company. No stock listing.
       
    26. HootOwl

      HootOwl Member Benefactor

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      God I had such high hopes for decibel 3 years ago. It’s depressing to return to this thread and find Park adventure pictures.

      I’m hoping they are just keeping all of their cards close to their chest right now.
       
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    27. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      What I don't understand is that the chemicals/biologics that they want to test already exist and have animal testing data. What are they friggen waiting for?

      Imagine going to a country in a famine with starving people and setting up a kitchen in front of them and not cooking any food or telling them when you are going to start cooking.
       
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    28. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      This company is really good at posting pictures of themselves hanging out and doing sports. What if they are just purposefully wasting time to keep other companies from popping up and jumping in the market? They really aren't doing anything meaningful at all.
       
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    29. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Their main thing right now is a drug that protects from cisplatin (chemotherapy) ototoxicity.

      CURCUMIN has already shown to have the same effect.

      This is from the Journal of Otology and Neurotology

      "Results Curcumin treatment attenuated hearing loss induced by cisplatin, increased OHC survival, decreased 4-HNE expression, and increased HO-1 expression.

      Conclusion This preclinical study demonstrates that systemic curcumin attenuates ototoxicity and provides molecular evidence for a role of HO-1 as an additional mediator in attenuating cisplatin-induced damage."

      https://journals.lww.com/otology-ne...ma_Longa__Curcumin__Decreases_In_Vivo.35.aspx
       
      • Informative Informative x 2

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