Decibel Therapeutics

Discussion in 'Research News' started by Contrast, Jan 9, 2019.

    1. Arseny
      Wishful

      Arseny Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Possibly from problems with blood flow
      You need to ask them one by one. No one will agree to do it publicly.
      Even in Russia no clinic will agree for anything that's not regulated, but if you ask nicely you can do pretty much anything as long as you sign the waiver.

      I don't think there's a secret ingredient and these drugs are at least 1-2 years away from market. You have more chances on recovery if you do it now vs 2 years later.
       
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    2. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      upload_2019-3-4_16-59-7.png
      Glad we're at the bottom of this list. Why can't multiple companies be working on each of these things instead of one company slowly going one at a time? If they have a clue how to treat this then why would there be any delay whatsoever?
       
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    3. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
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    4. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      Is it just me or did Decibel Therapeutics go backwards? This company is a waste. They have incorrect priorities. At this point I only hope they don't clog up the research feed touting how much money they've received from investors.
       
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    5. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      I'm confused as well. I had high hopes for these guys. It doesn't seem like they have anything even close to phase 1 for hearing loss.
       
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    6. AUTHOR
      AUTHOR
      Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      They are playing it safe with anti-ototoxic drugs before they move on to the regenerative fantasy stuff. If they stick to simpler task like rushing anti-ototoxic agents for cancer patients, they'll get success which means more funding for research. They need to learn more about hidden hearing loss, noxacusis and the inner ear before they put out a therapeutics for it.

      We aren't first on their list because we are more difficult to treat and they don't want to blow it.
       
      • Agree Agree x 5
    7. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      upload_2019-8-20_10-28-7.jpeg

      Definitely playing it loose.
       
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    8. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I just noticed from this latest graph that their auditory neuropathy/tinnitus drug in pre-clinical says it's a biologic. This seems like a really different approach and i am very curious about it.
       
    9. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      It's probably BDNF.
       
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    10. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I was just assuming it would be something so far untried since Otonomy has BDNF covered. Maybe like NT-3?

      There must be something (not BDNF) that they found that shows (or also shows) promise in addressing synaptopathy and tinnitus.
       
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    11. serendipity1996

      serendipity1996 Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced

      Attached Files:

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    12. AUTHOR
      AUTHOR
      Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      Decibel Therapeutics Announces Leadership Transition

      Biotech veteran Laurence Reid to lead company as CEO Steven Holtzman retires

      https://www.businesswire.com/news/h...-Therapeutics-Announces-Leadership-Transition

      “Decibel’s deep understanding of the biology of the inner ear gives us a unique opportunity to develop life-changing therapeutics for these disorders. I believe that Decibel has built a superb research and drug discovery team, and I am excited to help that team exploit these opportunities in transformative ways.”
       
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    13. serendipity1996

      serendipity1996 Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
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    14. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I found this researcher on Rockefeller's site:

      https://www.rockefeller.edu/our-scientists/heads-of-laboratories/1186-a-james-hudspeth

      "The team is also studying how individual nerve fibers distinguish between hair cells of the two functional polarities, selectively innervating only one of the two sets."

      He has a wiki too but it reads a bit like he wrote it himself.
       
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    15. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
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    16. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      This quote stood out:

      "We’ve screened 80,000 drugs so far and we have two compounds in particular that look promising. We’re now trying to learn in more detail how they operate, and whether they or related compounds could be used for regeneration in humans."

      It's nice to see that researchers are really pouring their heart and soul into this. It's very clear.
       
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    17. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      Yes. Amazing. The work involved. It would be nice actually if he or his lab were involved in developing a working treatment after 50 years of pure research in hearing.
       
    18. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma

      upload_2020-1-30_11-11-25.png

      I don't know what you think about it, but to me, comparing these two pipeline updates, I think there a real step backyard: it means that DB-XX5 disappeared (it turned out to be a bad compound so they are looking for a new drug candidate) and the indication "tinnitus" disappeared.

      Edit: sorry for the size of the screenshot, maybe someone else can do it better.
       
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    19. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      It looks like their cochlear regeneration focus is now on something called a "LATS inhibitor" which appears to be a novel approach. Not sure what it repairs exactly, they really aren't yet saying.

      From their website:

      "Decibel today announced an exclusive worldwide option agreement with The Rockefeller University, which has discovered a novel series of small-molecule LATS inhibitors. LATS kinases are a core component of the Hippo signaling pathway, which plays a key role in regulating both tissue regeneration and the proliferation of cells in the inner ear that are crucial to hearing and balance. The agreement gives Decibel an exclusive option to license this series of compounds across all therapeutic areas."
       
    20. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      All I could find so far on LATS or the Hippo pathway for regeneration is this:

      https://www.ncbi.nlm.nih.gov/pubmed/27535619/

      It look like it is being studied to regenerate the liver.

      One thing I have also read so far is that these inhibitors also expand progenitor cells and activate native stem cell growth. So perhaps it would be especially useful in situations where a lot of support cells were lost (severe deafness or ototoxicity from Cisplatin and some antibiotics). Or if Audion depletes too many support cells?

      As @Frédéric pointed out, Decibel appear to have shifted from their "neuropathy/tinnitus" compound and have added this one instead.
       
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    21. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
    22. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      The paper reference above is for vestibular regrowth. They have a separate LATS hearing one I believe but less far along in pre-clinical.

      Doubled checked. That paper refers to their vestibular regeneration drug.
       
    23. Nonomat
      Wishful

      Nonomat Member Benefactor

      Location:
      France
      Tinnitus Since:
      06/2019 (mild) - 11/2019 (intrusive)
      Cause of Tinnitus:
      Noise induced
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    24. Joeseph Stope

      Joeseph Stope Member

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      noise? infection? negative stress? other?
      So Frederic is right then? i.e. they are laying off staff, winding down the tinnitus side of their drug discovery?
      Well that's just one firm.
       
    25. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      This company's management were dogshit con-artists from the start. F them and their former sleaze-bag CEO for wasting all that investor money.
       
      • Agree Agree x 2
    26. reggie green
      Balanced

      reggie green Member

      Tinnitus Since:
      03/08/2001
      I hate to hear that about the CEO. So there is no hope for tinnitus.
       
    27. MrCrybaby

      MrCrybaby Member Benefactor

      Tinnitus Since:
      2014, 10/2019
      Cause of Tinnitus:
      School Band, Acoustic Trauma
      I’m out of the loop, what did he do?
       
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