Decibel Therapeutics

Discussion in 'Research News' started by Contrast, Jan 9, 2019.

    1. Juan

      Juan Member

      Tinnitus Since:
      08/2014
      Cause of Tinnitus:
      Several causes
      Yes, they seem to be far away from any cure:

      https://www.decibeltx.com/pipeline/
       
    2. AUTHOR
      AUTHOR
      Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
    3. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      Sound Pharmaceuticals is even closer, though it'd be more beneficial for hyperacusis than tinnitus.
       
    4. Juan

      Juan Member

      Tinnitus Since:
      08/2014
      Cause of Tinnitus:
      Several causes
      I recently read the book "volume control" by David Owen, and the whole book was like "this is the best time in history to have hearing problems, there are so many options, cochlear implants, hearing aids, lipreading courses, brainstem implants blah blah blah"...

      And 20 pages on he will be like "well, cochlear implants cannot really make isolated words really discernible", "hearing aids barely work in most situation, people use them for a week and then put it in a drawer" and so on...

      The bottom line is there's nothing yet to cure sensorineural hearing loss, and people cope the best they can, making do without all that useless "technology".

      The only advancement has really derived from patients' complaints, although ENTs want to credit themselves with this "great discovery": the reality of hidden hearing loss, basically people with decent audiograms that hear like shit and cannot understand speech in noise at all.
       
    5. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Many people from within the traditional ENT space aren’t exactly happy with what some of these firms working on restorative medicine are doing because they are apparently stepping on them and working on things that they haven’t been able to do.

      One example was that bizarre article about Frequency Therapeutics and FX-322 which came out of the blue that wanted to criticise it. In the article they actually interview some experts in this field who put forward opinions on it, including one from a board of Decibel Therapeutics too. This guy made some rather ridiculous and spurious claims about FX-322 which consequently ignored what had been done and also actually contradicted the science.
       
    6. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Frequency Therapeutics and Sound Pharmaceuticals are ahead, although I’d suggest that if Otonomy are successful with OTO-413 then they too will not be far behind. Basically I think that these three firms are after delivering treatments as quickly as they can and want to deliver benefit as fast as they can.
       
    7. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      • Informative Informative x 6
    8. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      Good news! It's great to see technology improving.
       
      • Agree Agree x 3
    9. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      Another day, and one more company closer to a cure. It's getting brighter every day.
       
      • Agree Agree x 2
    10. Princebeyel
      Depressed

      Princebeyel Member

      Tinnitus Since:
      March 2020
      Cause of Tinnitus:
      Otoxin
      Is anyone aware if this would help with hair cells lost/damaged due to ototoxic medication?
       
    11. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      AAV therapies in general might one day but this particular drug is for genetic hearing loss due to a deficiency in Otoferlin and isn't a regeneration therapy.
       
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    12. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      This is actually similar stuff to what Akouos is doing, isn’t it?

      I was also wondering why a lot of these hearing related pharmaceutical organisations are based in Boston (as a non American I am interested)?
       
    13. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      It is similar to Akouos, yes.

      There are a few biotech hubs around the country (centered around high research university presence because that's where the initial research comes from) and Boston is one of the top hubs.
       
      • Like Like x 1
    14. lymebite
      Vegged out

      lymebite Member Podcast Patron Benefactor

      Location:
      United States
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Unknown
      Many of them are the result research conducted by Harvard University and the Massachusetts Institute of Technology, both located in Cambridge, Massachusetts (adjacent to Boston) so Boston is a natural place for the organizations to be located.

      This link, for example, shows many of the start-up organizations related to the Harvard Stem Cell Institute - Frequency Therapeutics and Decibel Therapeutics among them:

      https://hsci.harvard.edu/startups
       
      • Like Like x 2
    15. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Exactly... Massachusetts and its universities, MIT and Harvard and affiliated hospitals is where a lot of research and magic starts. Politics does affect this as many of the PhD and researchers are from foreign countries. I am concerned and saddened by my nation's anti science and foreign sentiment... Harvard's wealth is on par with a small developing nation.

      I forgot to say hi, big hug to my friend FGG!

      @tommyd87, hi, I grew up in Boston. The city is basically built around universities, hospitals, and their spin off companies. I am super proud of that, orrather, I like that about my city very much. You've got to see it to believe it. It's amazing. Hope you can visit one day.

      Daniel
       
      • Like Like x 2
    16. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      • Like Like x 4
      • Informative Informative x 3
    17. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      • Optimistic Optimistic x 1
    18. AUTHOR
      AUTHOR
      Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      • Like Like x 11
      • Winner Winner x 1
    19. antonio77

      antonio77 Member

      Tinnitus Since:
      1991
      Cause of Tinnitus:
      unknown
      Great news. I have always thought about children who receive Cisplatin and become deaf along with tinnitus.

      Probably the worst thing that can happen to a child.
       
      • Agree Agree x 3
    20. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron Hall of Fame

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      • Informative Informative x 6
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    21. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      IPO date is set for 2/12/21 at initial share price between $16 to $18.

      Right now, the only drug in clinical is a preventative for chemo related hearing loss but they do have quite a few drugs in pre-clinical including 3 genetic deafness drugs, vestibular hair cell growth drugs.

      It seems like the publicly traded companies move much faster in terms of development.
       
    22. Jrblovsky

      Jrblovsky Member

      Location:
      USA
      Tinnitus Since:
      Christmas 2019
      Cause of Tinnitus:
      NOISE/Menieres Who knows
      Of course they do. The have shareholders and a board of directors to push them to get shit done.
       
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