Episode 11: Reviving Retigabine for Tinnitus — Thanos Tzounopoulos, PhD

Discussion in 'Podcast' started by Tinnitus Talk, May 24, 2020.

    1. tinnitus-talk-podcast-episode-11-reviving-retigabine.png

      Hi everybody!

      A few years ago, a drug called Retigabine (Trobalt) was taken off the market, in spite of showing some promise in treating tinnitus. Today, Thanos Tzounopoulos is working to redesign the drug to target and silence the tinnitus signal in the brain.

      We’re very excited that we were (finally) able to get Thanos on the podcast! He was a pleasure to speak with and clearly very passionate about helping people suffering from tinnitus.

      In this episode, he explains his underlying theory of how tinnitus works and talks about getting the drug ready for clinical trials in the next two years.



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      Listen on:

      We welcome any discussion, but please keep the following in mind when commenting:
      • Off-topic comments, i.e. not directly responding to the content of the podcast, will be removed. So please do listen before commenting!
      • While we welcome constructive criticism on ideas or policies, we do not tolerate direct attacks on individuals.

      This episode was produced, as usual, by @Markku and @Hazel and @Autumnly. Transcription was done by @Liz Windsor and the newest member of our podcast team @Andrea Rings. Do you want to volunteer as well? Let us know!

      We also thank our Patreon supporters for making this podcast possible.

      Don't forget to:

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    2. Croaker
      Haunting

      Croaker Member Benefactor

      Tinnitus Since:
      01/2019 T, 04/2020 H
      Cause of Tinnitus:
      Headphones/Car Alarm/Immune Response?
      Thank you for your work.

      So he wants to hit the Kv7.2 and 3 potassium channels? There are potassium channel drugs in phase 2 right now (Xenon’s XEN-1101) that target the same channels! Of course they haven’t officially named tinnitus as a condition they are looking to address yet.

      edit: I don’t mean to sound negative, it’s great that he’s working on treating us specifically. I just think it’s a funny situation. At least we know a tinnitus drug is coming, whatever happens with FX-322/Hough Ear Institute/Xenon etc.
       
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    3. aot
      Depressed

      aot Member Benefactor Hall of Fame

      Location:
      USA
      Tinnitus Since:
      2016. Worsened 11/2019.
      Cause of Tinnitus:
      Probably sound induced, worsened due to noise expouse + flu.
      Another great episode!
       
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    4. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      Wow, this is just what I needed to understand the voltage gating of the potassium ion channels better. Thanks Hazel!
       
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    5. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron Hall of Fame

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      This was a really comprehensive and informative podcast and it's clear Thanos is very enthusiastic about his research. Interesting that he himself also has hearing damage and tinnitus. It's very heartening to hear that everything is going smoothly so far.
       
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    6. DoNotGoGentle

      DoNotGoGentle Member Benefactor

      Tinnitus Since:
      10/15 got worse 11/16
      Cause of Tinnitus:
      Earbuds, inner ear infection NHL and high frequency loss
      If I remember correctly, they did state tinnitus a few years back but for some reason they took it off the website.
       
    7. BigNick

      BigNick Member Podcast Patron

      Tinnitus Since:
      11/2018
      Cause of Tinnitus:
      Unknown
      He sounds pretty confident.
       
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    8. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      -
      Cause of Tinnitus:
      -
      This is one of the greatest podcast episodes ever. This was very informative. I hope Thanos' drug is one of the cures for tinnitus and hyperacusis.

      There are so many drugs currently in clinical trials that can help us. It’s good how different companies are doing different things to solve these issues. This gives it a good idea on what works for hyperacusis and tinnitus and what doesn’t so in the future they could make a drug even more potent to target those channels.
       
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    9. MBH

      MBH Member

      Location:
      Upstate NY
      Tinnitus Since:
      06/2017
      Cause of Tinnitus:
      Overloaded stress
      They once thought that Retigabine might work, so now they will tweak it and make it work properly. What a great idea to put it together again.
       
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    10. Joly

      Joly Member

      Tinnitus Since:
      22/08/2019
      Cause of Tinnitus:
      Traumatisme sonore
      When could this treatment become available?
       
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    11. UHPTS
      Wishful

      UHPTS Member

      Tinnitus Since:
      October 2019
      Cause of Tinnitus:
      Ear infection
      Thanks for the podcast! Gives a lot of hope.

      Where can I sign up for the clinical trial? :)
       
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    12. Paulmanlike

      Paulmanlike Member Benefactor Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Great podcast! I'll make a few notes from it.

      - This drug is still getting designed and it may take 1 to 2 to get into clinical trials. It's important to remember, that just 11% of drug trialed ever reach the market.
      - XEN-1101, which is not specifically designed for tinnitus, is in phase 2. It may benefit tinnitus, however it's an epilepsy drug.
      - Thanos does not plan to die before a drug has been released for tinnitus. I love his determination, but the odds are against him. It would be one hell of an achievement. Nobel Prize or whatever they give should be awarded.

      I would have liked to hear his thoughts on inner hair cell regeneration and whether he thought, if that was successful, if it would reverse tinnitus; as it is only speculation that this will happen. I am curious also as to what his thoughts are on Susan Shore's and Hubert Lim's work and bimodal stimulation. I am always keen to hear what the 'competition' have to say.
       
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    13. Hazel
      Dreaming

      Hazel Director Staff Podcast Patron Benefactor Hall of Fame Advocate

      Location:
      the Netherlands
      Tinnitus Since:
      10/2017
      Cause of Tinnitus:
      one-sided hearing loss (of unknown origin)
      Nice summary, thanks!
      We initially sent him a more extensive list of questions, based on Tinnitus Talk user input, but we scrapped some questions that he did not feel well positioned to answer. I don't recall to be honest if the questions you posed were included there, but might well have been.

      Academics usually prefer to stick to their own topic of expertise, which I completely understand from their perspective; they're scientists, so they want to avoid speculation as much as possible.
       
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    14. Gabriel5050
      Balanced

      Gabriel5050 Member Podcast Patron Benefactor

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      Noise exposure (most likely)
      Really great episode! Thanos came across as very intelligent, enthusiastic and even charismatic.

      It was very informative and nice to listen to, once I got used to his accent.
       
    15. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      Come one, he isn't that old! :-D

      Very interesting podcast. Like others have said, this drug is still in the preclinical stages so there's so much that can still go wrong.

      But in any case, he's doing some very interesting science and even if this fails, through his research we'll learn much more about the causes of tinnitus, TTTS and hyperacusis.
       
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    16. Bobbette

      Bobbette Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Unknown
      GOLDEN interview!! Gives so much hope!
       
    17. Maite

      Maite Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Benzos/some ear hair cells
      Can this drug help pulsatile tinnitus as well?
       
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