Experimental Nootropic: Fasoracetam

Discussion in 'Alternative Treatments and Research' started by linearb, Apr 1, 2015.

    1. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      So, this one is kind of interesting:
      http://en.wikipedia.org/wiki/Fasoracetam
      http://nootriment.com/fasoracetam/
      GABAb is strongly implicated as a tinnitus vector in a couple studies.
      http://www.ncbi.nlm.nih.gov/pubmed/15570498
      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360237/

      The (completely unavailable) l-isomer of baclofen in isolation from the d-isomer that's included with it in all commercial baclofen products, had a strong effect on tinnitus:
      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297816/

      So, then the question is "if a lack of GABAb initiated inhibition is involved in tinnitus signal propagation, and if Fasoracetam can specifically upregulate GABAb receptors, will consumption of fascoracetam decrease tinnitus signal strength?"

      I think it is an interesting question, enough so that I acquired samples of fasoracetam from a couple different vendors. Unfortunately, this stuff doesn't even have "supplement" status, meaning that any you are likely to acquire will be made by a chinese lab and come in a mailer that says "RESEARCH SAMPLE. NOT FOR HUMAN CONSUMPTION".

      My days of willingly consuming such things are probably a little bit behind me. But, it is out there! I will be keeping my eyes open for a USP grade source of this material.
       
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    2. Carm

      Carm Member

      Tinnitus Since:
      04/01/2011
      Please if you find a quality source for this, can you give a link.
       
    3. AUTHOR
      AUTHOR
      linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      There are no "quality" sources. Centropic and TeamLTR both sell it as a research product, shipped in envelopes that clearly say "NOT FOR HUMAN CONSUMPTION". Powdercity.com appears to sell it with a slightly less stringent disclaimer, "This nootropic is not considered a dietary supplement and as such should only be taken under the guidance of a doctor or in a research setting."

      I obtained 1-gram samples of material from both Centropic and TeamLTR, but haven't had time to send them off for GC/MS analysis yet. Even if both samples pass mass spec analysis as 99.999x% pure, I am not extremely enthusiastic about ingesting chemicals with very, very, very limited human consumption data behind them... I mean, I haven't even been willing to subject myself to Trobalt mostly for that reason, and we know a hell of a lot more about Trobalt than we do about this stuff.

      It is interesting, though.
       
    4. AUTHOR
      AUTHOR
      linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      After getting a half-assed GC/MS analysis done I have been experimenting with this, first with 20mg and now up to about 50mg 2x/day.

      It does seem to have some slight impact on T at these doses; it's also pretty clearly a psychoactive compound, notably more so than piracetam.

      I will probably max out at about 150mg/day, for no more than a few days, and then shelve it for some period of time. The mechanism of action is intriguing and the effects are not unpleasant, but the scant human data is a little worrying from the perspective of anything further than very limited use.
       
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    5. Krolo

      Krolo Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999 , Worse in September 2018
      Cause of Tinnitus:
      Loud Volume
      Dusting of some more of your threads here. How did this one turn out for you in the end? And do you have any other interesting compunds you tried during the years ? :)
       

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