Experimental Nootropic: Fasoracetam

Discussion in 'Alternative Treatments and Research' started by linearb, Apr 1, 2015.

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    1. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      So, this one is kind of interesting:
      http://en.wikipedia.org/wiki/Fasoracetam
      http://nootriment.com/fasoracetam/
      GABAb is strongly implicated as a tinnitus vector in a couple studies.
      http://www.ncbi.nlm.nih.gov/pubmed/15570498
      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360237/

      The (completely unavailable) l-isomer of baclofen in isolation from the d-isomer that's included with it in all commercial baclofen products, had a strong effect on tinnitus:
      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297816/

      So, then the question is "if a lack of GABAb initiated inhibition is involved in tinnitus signal propagation, and if Fasoracetam can specifically upregulate GABAb receptors, will consumption of fascoracetam decrease tinnitus signal strength?"

      I think it is an interesting question, enough so that I acquired samples of fasoracetam from a couple different vendors. Unfortunately, this stuff doesn't even have "supplement" status, meaning that any you are likely to acquire will be made by a chinese lab and come in a mailer that says "RESEARCH SAMPLE. NOT FOR HUMAN CONSUMPTION".

      My days of willingly consuming such things are probably a little bit behind me. But, it is out there! I will be keeping my eyes open for a USP grade source of this material.
       
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    2. Carm

      Carm Member

      Tinnitus Since:
      04/01/2011
      Please if you find a quality source for this, can you give a link.
       
    3. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      There are no "quality" sources. Centropic and TeamLTR both sell it as a research product, shipped in envelopes that clearly say "NOT FOR HUMAN CONSUMPTION". Powdercity.com appears to sell it with a slightly less stringent disclaimer, "This nootropic is not considered a dietary supplement and as such should only be taken under the guidance of a doctor or in a research setting."

      I obtained 1-gram samples of material from both Centropic and TeamLTR, but haven't had time to send them off for GC/MS analysis yet. Even if both samples pass mass spec analysis as 99.999x% pure, I am not extremely enthusiastic about ingesting chemicals with very, very, very limited human consumption data behind them... I mean, I haven't even been willing to subject myself to Trobalt mostly for that reason, and we know a hell of a lot more about Trobalt than we do about this stuff.

      It is interesting, though.
       
    4. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      After getting a half-assed GC/MS analysis done I have been experimenting with this, first with 20mg and now up to about 50mg 2x/day.

      It does seem to have some slight impact on T at these doses; it's also pretty clearly a psychoactive compound, notably more so than piracetam.

      I will probably max out at about 150mg/day, for no more than a few days, and then shelve it for some period of time. The mechanism of action is intriguing and the effects are not unpleasant, but the scant human data is a little worrying from the perspective of anything further than very limited use.
       
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