Frequency Therapeutics — FX-345

[Foamearplugssuck]

Do you think FX-345 can help with hypercacusis? Could it be just the brain on high drive from hearing loss in higher frequencies...

I've been wondering this too. I know there's really no way to know until the drug comes out, but I am impatient! And I would like to know how much longer I will have to deal with this shit.

 

[Joeseph Stope]

If the theory that Type II nerve fibers send out pain signals because the outer hair cells they're connected to are damaged, then restoring those hair cells might help. But for now we can only speculate.

I'm not one to pee on your parade -- and believe me I am really happy that some of the smartest minds in the scientific community are trying to tackle this thousands-year-old problem --- but I think that a patient, sober, long-term attitude is the best way. It could be a Eureka! -moment --- Problem solved. Next please.

But more that there is also the chance that the cochlea and the auditory system is something very complex. That this scientific thrust will uncover some new ground, and maybe even improve some of the aspects --- such as speech in noise (hearing clarity).

After all, some people have hearing loss but no tinnitus. Some people have tinnitus but no hearing loss. Some people have hyperacusis, noxacusis or neither.

Different strokes for different folks.

Let's just suppose that FX-322 and FX-345 can just improve hearing in noise... They'll still clean up. After all, they will be the only show in town -- aside from hearing aids... and they both can also be used together.

 

[Nobody19]

Oh I very much agree @Joeseph Stope. That's why I think it can help, I don't think this alone will cure hyperacusis. But again, we can only speculate. It's not even being tested for hyperacusis.

 

[Diesel]

Oh I very much agree @Joeseph Stope. That's why I think it can help, I don't think this alone will cure hyperacusis. But again, we can only speculate. It's not even being tested for hyperacusis.

Let's keep in mind that not being tested in the Clinical Trial doesn't mean that the company doesn't think it will help. The exclusion/inclusion criteria in all of these trials is to ensure the company has a reliable/measurable/well understood population of patients to collect data from on their drug. Adding hyperacusis is a variable that isn't well understood, and therefore those patients may cause outcomes in the trial that put the progress of the drug at risk.

 

[Jurger]

Just watched this Fireside chat by Frequency Therapeutics:

https://www.webcaster4.com/Player/I...-0c79-4079-ba1b-7631deefbbcd&uid=6671331&sid=

An interesting moment was when Chris Loose was asked if FX-345 could leapfrog FX-322. He said it was "too early to speculate" (around 15:00).

 

[RingingBrother]

Anyone know of any email contact we can ask to bring a trial to our location? I live in Miami and didn't have any luck with FX-322 trials.

 

[patorjk]

Anyone know of any email contact we can ask to bring a trial to our location? I live in Miami and didn't have any luck with FX-322 trials.

Their website lists this email contact: clinicaltrialsinformation@frequencytx.com

I asked them some questions earlier this year and they got back to me in 9 days (not great, but it was a real human). As an aside, they cover travel expenses if you get accepted into the trial.

 

[Geatly]

Their website lists this email contact: clinicaltrialsinformation@frequencytx.com

I asked them some questions earlier this year and they got back to me in 9 days (not great, but it was a real human). As an aside, they cover travel expenses if you get accepted into the trial.

Why don't they start with the FX-345 trial right now, as they have already chosen the compound, why wait until autumn?

 

[Diesel]

Why don't they start with the FX-345 trial right now, as they have already chosen the compound, why wait until autumn?

Application takes time with FDA, setting up trial sites takes time, staff limitations to manage more than 1 trial.

 

[RingingBrother]

Their website lists this email contact: clinicaltrialsinformation@frequencytx.com

I asked them some questions earlier this year and they got back to me in 9 days (not great, but it was a real human). As an aside, they cover travel expenses if you get accepted into the trial.

I got an automated response with another email for Clara Health and I sent them the same question.

 

[RingingBrother]

Do they know yet if these drugs were effective toward sudden hearing loss/deafness in one ear?

 

[Joeseph Stope]

Well, whatever else, nobody can complain that tinnitus sufferers are not getting attention at this point in time.

Frequency Therapeutics and Otonomy are working on the hair cell rejuvenation.

Dr. Susan Shore working on the fusiform cells -- brain side of things.

The South Korean brigade working on the facial nerves and Lidocaine.

Deb in Australia's crowd working on an objective indicator of the presence of tinnitus. Who knows? Maybe they will learn to find an objective way of measuring it.

And much much more out there. You've never had it so good. but all we want is one little cure... or maybe a way of turning down the volume.

It could very well be that what's needed is a combination of Dr. Susan Shore's brain side of the solution and Frequency Therapeutics/Otonomy/Pipeline Therapeutics' cochlear solution.

 

[scotty03874]

I got an automated response with another email for Clara Health and I sent them the same question.

I connected with them. I was asked where they could obtain my audiograms after E-signing a HIPPA release. They told me through email they obtained my hearing tests. We will see if I make it into a trial.

 

[RingingBrother]

I connected with them. I was asked where they could obtain my audiograms after E-signing a HIPPA release. They told me through email they obtained my hearing tests. We will see if I make it into a trial.

Do you think it'd be possible to convince them to bring an FX-345 trial to Miami if I keep emailing them the same question? I'm willing to take the risk of being in Phase 1 trials.

 

[Eliot Martin]

Do you think it'd be possible to convince them to bring an FX-345 trial to Miami if I keep emailing them the same question? I'm willing to take the risk of being in Phase 1 trials.

It would be better to wait until Phase 1b results are out in the first half of 2023. And if results are positive (better than FX-322), maybe they will allow Expanded Access?

Let's hope for the best.

 

[Diesel]

Do you think it'd be possible to convince them to bring an FX-345 trial to Miami if I keep emailing them the same question? I'm willing to take the risk of being in Phase 1 trials.

No, probably not.

if results are positive (better than FX-322), maybe they will allow Expanded Access?

No, probably not.

 

[James Connelly]

Hi all. I stupidly stood too close to speakers at a gig, which made my tinnitus worse and I now have difficulty following conversations and hearing in noisy environments. My audiograms are fine but I definitely have problems hearing.

Probably a stupid question but would FX-322 help me at all with my inability to follow conversations or is it best to wait for FX-345?

 

[Diesel]

Hi all. I stupidly stood too close to speakers at a gig, which made my tinnitus worse and I now have difficulty following conversations and hearing in noisy environments. My audiograms are fine but I definitely have problems hearing.

Probably a stupid question but would FX-322 help me at all with my inability to follow conversations or is it best to wait for FX-345?

FX-322, FX-345, or OTO-413 could help you individually or in combination. It's too early for anyone on this forum to give you a definite answer.

 

[Eliot Martin]

Hi all. I stupidly stood too close to speakers at a gig, which made my tinnitus worse and I now have difficulty following conversations and hearing in noisy environments. My audiograms are fine but I definitely have problems hearing.

Probably a stupid question but would FX-322 help me at all with my inability to follow conversations or is it best to wait for FX-345?

Try joining the Clinical Trial and you will get your answer.

 

[InNeedOfHelp]

H.C. Wainwright Global Investment Conference - May 23-26, 2022 - Hybrid Conference

Presentation from Frequency Therapeutics from 24th of May. General overview of the studies and interestingly also showing the potential target group which they are aiming for.

 

[Street Novelist]

H.C. Wainwright Global Investment Conference - May 23-26, 2022 - Hybrid Conference

Presentation from Frequency Therapeutics from 24th of May. General overview of the studies and interestingly also showing the potential target group which they are aiming for.

Any new information? Do they say when the FX-345 trial will begin?

 

[Chad Lawton]

Any new information? Do they say when the FX-345 trial will begin?

Nothing new to report. FX-345 trial is anticipated to start in the 2nd half of this year.

 

[vttbx]

FX-322, FX-345, or OTO-413 could help you individually or in combination. It's too early for anyone on this forum to give you a definite answer.

Do you honestly believe that all three could be complementary to each other?

 

[Diesel]

Do you honestly believe that all three could be complementary to each other?

No. I think either FX-345 OR FX-322 could be complimentary to OTO-413. The drugs address exclusive underlying conditions of Acquired SNHL.

 

[Geatly]

I wonder, if there are companies that can deliver drugs to the entire cochlea, why don't they collaborate with Frequency Therapautics, and bring such a delivery system to them, because then they can reach and treat the entire frequency range.

 

[reggie green]

I wonder, if there are companies that can deliver drugs to the entire cochlea, why don't they collaborate with Frequency Therapautics, and bring such a delivery system to them, because then they can reach and treat the entire frequency range.

Maybe greed and politics. The idea had to come across these companies. Researchers are sometimes reluctant to share information with each other.

Maybe we can make a suggestion for companies to collaborate on research. LOL. Wishful thinking, right?

 

[Bruce NH USA]

I connected with them. I was asked where they could obtain my audiograms after E-signing a HIPPA release. They told me through email they obtained my hearing tests. We will see if I make it into a trial.

Same with me. I wonder, though, if it is worth it to participate in the FX-322 trial when FX-345 seems to be much more robust? Is it worth the risk? Will it help with tinnitus? I don't have that much hearing loss, just some at 4-5 kHz.

 

[John Joseph]

Same with me. I wonder, though, if it is worth it to participate in the FX-322 trial when FX-345 seems to be much more robust? Is it worth the risk? Will it help with tinnitus? I don't have that much hearing loss, just some at 4-5 kHz.

I'm kind of wondering something similar. If we try FX-322 and it doesn't give sufficient results, would this at all interfere with the ability of FX-345 to work later down the road?

I do have some moderate high frequency loss that I'd love to fix, but definitely want something that gives the best possible results, even if it meant waiting a while longer.

However, if doing both is an option, or even better, if they give additive effects, I would jump on the FX-322 first.

 

[ThomasF]

I wonder if it helps whatsoever to give them access to one's medical records without attempting to participate in the trial. I'm not sure if it would help or maybe give the researchers a clearer idea of the problem areas for people. I know FX-322 and FX-345 are directed towards different parts of the cochlea but how many suffer from what area of hearing loss might be useful information no matter the status of trial participation.

 

[Bruce NH USA]

I'm kind of wondering something similar. If we try FX-322 and it doesn't give sufficient results, would this at all interfere with the ability of FX-345 to work later down the road?

I do have some moderate high frequency loss that I'd love to fix, but definitely want something that gives the best possible results, even if it meant waiting a while longer.

However, if doing both is an option, or even better, if they give additive effects, I would jump on the FX-322 first.

I'm not sure what to do, at this point. It takes up to eight weeks to determine eligibility, so I will see if they even accept me...